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Serum lipids and lipoproteins in middle-aged and elderly Chinese in Shandong Province
- WANG Meijian, HOU Xinguo, LIANG Kai, CHEN Li
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JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(5):
70-75.
doi:10.6040/j.issn.1671-7554.0.2016.1399
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Objective To explore the relationship between age, gender, BMI, blood pressure, status of glucose metabolism and serum lipids and lipoproteins among the middle-aged and elderly Chinese men and women in Shandong Province. Methods A cross-sectional study was conducted in Shandong Province among 10,028 adults aged ≥40 years. Demographic data were collected and oral glucose tolerance test was performed. Fasting serum total(Cho), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C)and triglycerides(TG)were measured by standard methods. Results The estimates of serum Cho, LDL-C, HDL-C and TG were(5.35±1.05)mmol/L,(3.18±0.86)mmol/L,(1.51±0.38)mmol/L and 1.34 mmol/L, respectively. The estimates of serum Cho, LDL-C, HDL-C and TG in female were higher than those in male, and differences in Cho, LDL-C and HDL-C were statistically significant(P<0.001). The levels of serum Cho, LDL-C and TG increased(P=0.005, P=0.012, P=0.043), while the level of serum HDL-C decreased(P=0.002)with the elevation of blood pressure. The levels of 山 东 大 学 学 报 (医 学 版)55卷5期 -王美建,等.山东省城市中老年人群血脂现状调查 \=-serum Cho, LDL-C and TG increased(P=0.013, P=0.023, P=0.007), while the level of serum HDL-C decreased with the increase of BMI(P=0.010). The levels of serum Cho, LDL-C between normal glucose tolerance population, pre-diabetes ［impaired fasting glucose(IFG), impaired glucose tolerance(IGT)and IFG accompany with IGT］ population and diabetic population increased first and then decreased(P<0.001), the level of serum HDL-C decreased gradually(P=0.007), and the level of TG increased gradually(P<0.001). Up to 36.92% and 19.10% adults had borderline high total cho(5.18-6.21 mmol/L)and high total cho(≥6.22 mmol/L); 25.24% and 13.39% population had borderline high(3.37-4.13 mmol/L)and high(≥4.14 mmol/L)HDL-C; 16.70% and 17.47% of the population had borderline high(1.70-2.25 mmol/L)and high(≥2.26 mmol/L)TG; 5.64% had low HDL-C(≤1.04 mmol/L). Conclusion Serum total and low-density lipoprotein cholesterol levels are high in the population aged ≥40 years in Shandong Province. Age, gender, BMI, blood pressure and status of glucose metabolism can affect serum lipids and lipoproteins. Without effective prevention and intervention, incidence of cardiovascular and cerebrovascular diseases will keep growing in the future.
