Objective To prepare an atherosclerosis(As)model employing an oxidised low-density lipoprotein(ox-LDL)-induced mouse macrophage cell line, so as to see whether microRNA-1270(miRNA-1270)interfered with macrophage inflammation and lipid metabolism via the angiopoietin-like protein 7(ANGPTL7)/p38 pathway. Methods Mouse mononuclear macrophages(RAW264.7)were cultured and ox-LDL was added to construct macrophage models. According to the different intervention conditions, the groups were as follows: blank group, ox-LDL group, ANGPTL7 group, p38 protein inhibition group, p65 protein inhibition group, miR-1270 mimic group, miR-1270 mimic negative control group, miR-1270 inhibitor group, and miR-1270 inhibitor negative control group. The mRNA expression level was detected by real-time quantitative PCR, the protein expression level was detected by Western bloting, and the lipid accumulation was detected by oil red staining. Results The number of macrophages containing red fat particles was increased in ox-LDL-exposed macrophages, with high expressions of ANGPTL7, p38, and IL-6, and low expression of IL-10, and a positive correlation between ANGPTL7 and p38 and lipid accumulation(P<0.01). Compared with the ANGPTL7 group, there was no significant difference in the relative expression of ANGPTL7 and p38 proteins in the p38 protein inhibition group, a decrease in the relative expression of IL-6 protein, an increase in the relative expression of IL-10 protein, and a decrease in the number of red adipose microparticle-containing macrophages(P<0.01). Compared with the ANGPTL7 group, there was no statistically significant difference in the expression of the indicators in the p65 protein inhibition group, and there was no statistically significant difference in the number of macrophages containing red fat particles(P>0.05). Compared with the blank group, the relative expression of miR-1270 gene was decreased and the relative expression of ANGPTL7 gene and protein was increased in the ox-LDL group, and miR-1270 was negatively correlated with the relative expressions of ANGPTL7 gene(r2=0.665 7, P<0.01). Compared with the ox-LDL group, the miR-1270 mimic group had increased relative expression of the miR-1270 gene, decreased relative expression of the ANGPTL7 gene and protein, decreased relative expression of the p38 and IL-6 proteins, increased relative expression of the IL-10 protein, and decreased number of red adipose microparticle-containing macrophages(P<0.01). The miR-1270 inhibitor group had a decrease in the relative expression of the miR-1270 gene, an increase in the relative expression of the ANGPTL7 gene and protein, an increase in the relative expressions of the p38 and IL-6 proteins, a decrease in the relative expression of the IL-10 protein, and an increase in the number of macrophages containing red adipose microparticles(P<0.01). Compared with the ox-LDL group, there was no significant difference in the expression of the indicators in the negative control group, and there was no statistically significant difference in the number of macrophages containing red fat particles(P>0.05). Conclusion In the ox-LDL-exposed macrophage model, ANGPTL7 promotes inflammation and lipid accumulation in macrophages via the p38 pathway, which is a new mechanism to promote the development of atherosclerosis. miR-1270, as a protective factor, can target and inhibit the transcriptional expression of the ANGPTL7 gene, reduce macrophage inflammation and lipid accumulation via the p38 pathway, and reversibly control the development of atherosclerosis, and is a potential early screening target for atherosclerosis. It is a potential target for early screening of atherosclerosis.

Objective To investigate the association of ACE insertion/deletion, kallilrein gene(KLK)1(rs5517), prostacyclin synthase gene(PTGIS)(rs5629)locus polymorphisms with susceptibility and degree of coronary artery disease for 250 patients with non ST segment elevation acute coronary syndrome(NSTE-ACS). Methods Clinical data of 200 patients with coronary artery disease and 50 patients with normal coronary arteries were collected and genotyped by PCR and Sanger sequencing, respectively. Susceptibility of the three genotypes and mutual-combination genotypes associated with NSTE-ACS were analyzed by binary Logistic regression using case-control groupings. Gensini score and SYNTAX score were used to express the degree of coronary artery stenosis, and multiple linear regression was used to analyze the association between the mutual-combination genotypes and the severity of coronary artery disease. Results In binary Logistic regression analysis, after adjusting for confounding factors such as age, LDL, and homocysteine, the genotypes associated with the risk of NSTE-ACS were ACE DD(OR=4.335, 95%CI: 1.105-17.016, P=0.036), KLK1 CC(OR=3.152, 95%CI: 1.077-9.230, P=0.036), and KLK1 TT& PTGIS TT(OR=0.065, 95%CI: 0.006-0.752, P=0.029). In multiple linear regression analysis, the combined genotype associated with Gensini score was ACE DD&KLK1 CC(β= 51.847, P=0.001), and the combined genotype associated with SYNTAX score was ACE DD&KLK1 CC(β=10.031, P=0.001). Conclusion ACE I/D genotype and KLK1(rs5517)genotype are associated with NSTE-ACS, and ACE DD genotype and KLK1 CC genotypes increase the risk of NSTE-ACS; KLK1 TT& PTGIS TT subtype may reduce the risk of NSTE-ACS patients of Han nationality in Shandong Province. ACE DD & KLK1 CC subtype is positively associated with the severity of coronary artery disease.

Objective To identify the influencing factors for the response to postoperative ¹³¹I treatment and prognosis in patients with intermediate and high-risk differentiated thyroid cancer(DTC)by employing optimal scale regression analysis and joint diagnostic ROC model analysis, so as to provide a reference basis for the development of clinical treatment plans. Methods A retrospective analysis was conducted on the clinical data of 414 patients with intermediate and high-risk differentiated thyroid cancer(DTC)who had undergone postoperative ¹³¹I treatment. The patients were divided into an intermediate-risk group(n=275)and a high-risk group(n=139)based on the risk of recurrence. Chi-square tests were used to compare the categorical data between the intermediate-risk and high-risk groups; the Mann-Whitney test was employed to compare the numerical data between the two groups. The Medcalc software was used to plot ROC curves and compare the diagnostic efficacy of predictive factors among the groups. Results Patients in the intermediate-risk and high-risk groups showed statistically significant differences in age, T stage, M stage, number of treatments, cumulative dose, thyroid-stimulating hormone, anti-thyroglobulin antibodies, and thyroglobulin levels(P<0.01). The effective predictive factors for treatment response in the intermediate-risk group were gender, number of treatments, and cumulative dose, with the cumulative dose having the largest area under the curve(AUC), but it was still smaller than the AUC of the combined diagnostic model of all three factors. In both the intermediate and high-risk groups, the cumulative dose, T stage, and M stage were predictive factors, with the cumulative dose having the largest AUC, which was also smaller than the AUC of the combined diagnostic model of the three factors. The effective predictive factors for mortality risk in the intermediate and high-risk groups were T stage and M stage, with M stage having the largest AUC. The AUC for the combined diagnosis of T stage and M stage was slightly larger than that of M stage alone. Conclusion The most effective single factor for predicting the treatment response in intermediate and high-risk DTC patients is the cumulative dose, while the most effective single factor for predicting the risk of death is the M stage. The efficacy of the combined diagnostic model of all predictive factors is higher than that of any single factor, suggesting that aggressive ¹³¹I treatment is beneficial for improving the prognosis of intermediate and high-risk DTC patients.

Objective To explore predictive markers that can trigger radiation recall pneumonitis(RRP)in patients with unresectable stage Ⅲ_B/C and Ⅳ non-small cell lung cancer(NSCLC)who receive immune checkpoint inhibitors(ICIs)following consolidative radiotherapy. Methods A retrospective analysis was conducted at Qingdao Municipal Hospital on patients with unresectable stage Ⅲ_B/C and IV NSCLC who underwent radiotherapy followed by sequential ICI therapy from March 2020 to November 2023. Patients were divided into RRP and non-RRP groups. Clinical information, including gender, age, body mass index, performance status score, TNM stage, mean lung dose(MLD), V20, blood pressure, FEV₁, FVC, FEV₁/FVC, PaO₂, PaCO₂, procalcitonin, interleukin-6(IL-6), peripheral blood CD4⁺ and CD8⁺ T-cell counts were collected and assessed through Logistic regression and ROC curve analysis to evaluate risk factors. Results A total of 55 patients were included, with 30 in the non-RRP group(54.45%)and 25 in the RRP group(45.45%), including 3 critical RRP cases(3/55, 5.45%). There were no statistically significant differences between the two groups in terms of gender, age, BMI, performance status score, TNM stage, MLD, V20, blood pressure, FEV₁, FVC, FEV₁/FVC, PaCO₂, procalcitonin, and CD4⁺ cell counts(P>0.05). The RRP group had significantly lower PaO₂(P=0.007)and CD8⁺ T-cell counts(P=0.040), and higher IL-6 levels(P<0.001)compared to the non-RRP group. Both PaO₂ and IL-6 showed high significance in univariate and multivariate analyses(P<0.01), while CD8⁺ T-cells were significant in multivariate analysis(P<0.05). In the ROC curve analysis, the AUC values ranked as PaO₂ > IL-6 > CD8⁺ T-cells. Conclusion Patients with unresectable stage Ⅲ_B/C and IV NSCLC undergoing radiotherapy followed by ICIs therapy have a low incidence of critical RRP, though a high incidence of RRP. Low PaO₂, elevated IL-6 levels, and decreased peripheral blood CD8⁺ T-cell counts can serve as high-risk predictors for ICI-triggered RRP, exhibiting considerable predictive accuracy.

Objective To assess the effects of ω-3 polyunsaturated fatty acids on the recovery of autonomic nervous system and intestinal function after laparoscopic colorectal cancer surgery with the assistance of heart rate variability monitoring devices and continuous bowel sound auscultation recorders. Methods A total of 126 patients who underwent laparoscopic radical surgery for colorectal cancer at Jiangsu Province Hospital of Chinese Medicine from February 2022 to June 2024 were selected and randomly divided into an observation group and a control group, with 63 cases in each group. The observation group started oral administration of an enteral nutrition preparation containing ω-3 polyunsaturated fatty acids(Supportan)on the first postoperative day. The control group initiated oral administration of a conventional enteral nutrition preparation(Nutison Fibre)on the first postoperative day. The study observed indicators of intestinal function recovery(time to bowel sound recovery, time to first flatus, length of postoperative hospital stay), heart rate variability indices reflecting autonomic nervous system function(SDNN, pNN50, LF, HF, LF/HF), stress-inflammatory markers(CRP, IL-1β, IL-2, IL-6, TNF-α, IFN-γ), and the occurrence of postoperative complications. Results The observation group had earlier recovery times for bowel sounds, first flatus, and first oral intake compared to the control group, with statistically significant differences(P<0.001). On the first postoperative day, the heart rate variability index pNN50 was higher in the observation group than that in the control group(P=0.031), and on the third day, the heart rate variability indices SDNN, pNN50, and HF were all significantly higher in the observation group than those in the control group(P=0.006, P=0.012, P=0.031). On the third postoperative day, the levels of stress-inflammatory markers CRP, IL-1β and IL-6 were lower in the observation group than those in the control group(P=0.032, P=0.035, P=0.001). There were no statistically significant differences in complication rate after surgery between the groups(P=0.767). Conclusion ω-3 polyunsaturated fatty acids facilitate the recovery of intestinal function after laparoscopic colorectal cancer surgery, maintain postoperative vagus nerve function, and mitigate systemic inflammatory responses.

Objective To screen out the candidate fecal microRNAs(miRNAs)that play a crucial role in the occurrence of advanced adenoma and evaluate their clinical value in the screening and diagnosis of advanced adenoma. Methods From June 2022 to December 2023, 110 patients with colorectal cancer treated at the Affiliated Hospital of Chengde Medical University were selected as the colorectal cancer group, 94 patients with advanced adenoma as the advanced adenoma group, and 80 healthy individuals undergoing physical examinations as the control group. Five colorectal cancer patients cancerous and adjacent tissues were sequenced using next-generation sequencing to identify abnormally expressed miRNAs. Quantitative real-time PCR(qRT-PCR)was used to detect the expression of abnormally expressed miRNAs in the faeces of 30 patients in the colorectal cancer group and 20 in the control group to obtain abnormal miRNAs in faeces. The colorectal cancer group, advanced adenoma group, and control group were randomly divided into a training cohort and a validation cohort in a 7∶3 ratio. qRT-PCR was used to detect the expression of abnormal miRNAs in faeces in both cohorts, and the screening and diagnostic efficacy of miR-29a-3p was evaluated using the receiver operating characteristic(ROC)curve. To verify the screening and diagnostic efficacy of miR-29a-3p, 3,039 subjects who underwent colonoscopy during the same period were used as the observation group, with direct colonoscopy and pathological examination when necessary to calculate the detection rate of advanced adenomas. Eighty-one subjects were used as the screening group, with faecal miR-29a-3p detection followed by colonoscopy and pathology if necessary,to calculate the detection rate of advanced adenomas in those with elevated faecal miR-29a-3p. The chi-squared test was used to compare the detection rates of the observation and screening groups. Results Five miRNAs(let-7c-5p,miR-203a-3p,miR-122-5p,miR-29a-3p,miR-92b-3p)were significantly higher in cancer tissues than adjacent tissues.Through the training cohort, it was confirmed that miR-29a-3p was significantly upregulated in feces of the advanced adenoma group(P<0.05), and the area under the ROC curve(AUC)for the diagnosis of advanced adenomas using faecal miR-29a-3p in combination with faecal occult blood test, gender and smoking history was 0.840. Further confirmation by the validation cohort showed that miR-29a-3p was highly expressed in faeces of the advanced adenoma group(P<0.05), and the combination of faecal miR-29a-3p with fecal occult blood test, gender and smoking history could be used for the diagnosis of advanced adenomas(AUC=0.807). The colonoscopy detection rate of advanced adenomas in the screening group using elevated fecal miR-29a-3p as a screening indicator was 39.2%, which was statistically different from the observation group(P<0.05). Conclusion miR-29a-3p is significantly upregulated in feces of advanced adenoma patients, and fecal miR-29a-3p has a high clinical diagnostic value for advanced adenoma.

Objective To enhance pediatricians understanding of celiac disease and reduce the rates of misdiagnosis and missed diagnosis by reporting 2 cases of celiac disease. Methods The clinical data and follow-up results of two pediatric patients with celiac disease who were admitted to the Department of Pediatrics at Shandong Provincial Hospital Affiliated to Shandong First Medical University were analyzed. Patient 1 was a male infant aged 1 year and 7 months who presented with progressive abdominal distension, diarrhea, and growth retardation. Patient 2 was a male child aged 4 years and 6 months who presented with persistent diarrhea accompanied by wasting for > 3 months. Both patients exhibited elevated levels of cows milk protein-specific IgE antibodies and total IgE. Celiac antibody testing revealed a significant increase in the levels of anti-tissue transglutaminase, anti-endomysial, and anti-deamidated gliadin peptide antibodies. Wanfang, CNKI, Chinese Medical Journal, and PubMed databases were searched using the keywords "celiac disease" and "cows milk protein allergy". Results Following cows milk protein avoidance and stimulation tests, patient 1 was diagnosed with celiac disease combined with cows milk protein allergy. Subsequent adherence to a gluten-free diet, cows milk protein avoidance, and symptomatic treatment improved abdominal distension and diarrhea during a follow-up period of 46 months with satisfactory growth and development. Patient 2 was diagnosed with celiac disease and suspected cows milk protein allergy and was subsequently referred to the Childrens Hospital of Fudan University for further treatment. Subsequent follow-ups revealed reduced diarrhea symptoms following symptomatic treatment, adherence to a gluten-free diet, cows milk protein avoidance, and oral hormone administration. However, wasting did not improve. Conclusion Children presenting with prolonged abdominal distension, diarrhea, wasting, and growth retardation should be monitored for possible celiac disease. It is crucial to remain alert to the potential coexistence of cows milk protein allergy, and treatment should focus on adhering to a gluten-free and cows milk protein-avoidance diet.

Objective To investigate the clinical features and gene variations of 3 children with glycogen storage disease type Ib(GSDIb), and to analyze the clinical effects of empagliflozin in the treatment of these 3 children with GSDIb. Methods The clinical data and genetic test results of 3 children with GSDIb admitted to Childrens Hospital Affiliated to Zhengzhou University from June 2020 to May 2023 were retrospectively analyzed. All 3 patients received empagliflozin treatment and dietary intervention, and were followed up for 1 to 3 years. This study also conducted a related literature review. Results All three patients were male. The age at the time of consultation spanned from 7 months to 1 year. The predominant clinical manifestations encompassed enlarged liver and retarded intellectual and motor development. Metabolic irregularities were manifested as abnormal liver function, fasting hypoglycemia, elevated serum lactic acid and triglycerides. All cases were accompanied by neutropenia. Compound heterozygous variations in the SLC37A4 gene were identified in all three individuals. The ages at the initiation of empagliflozin treatment were 1 year and 2 months, 1 year, and 1 year and 10 months respectively. The follow-up durations were 12 months, 17 months, and 36 months, respectively. No adverse reactions such as hypoglycemia, urinary tract infection, or abnormal liver and kidney function were observed. The clinical symptoms were ameliorated. This study uncovered a new variant site c.1287_1290del in the SLC37A4 gene, thereby expanding the variation spectrum of the SLC37A4 gene. Conclusion Children with GSDIb exhibit diverse clinical manifestations. There is neutropenia and functional deficiency. Diagnosis relies on genetic testing. Empagliflozin can increase the number of neutrophils in children with GSDIb and improve their clinical symptoms. Early application can avoid the occurrence of inflammatory bowel disease.

Objective To investigate the causal relationship between the nine cathepsins and frailty index at the genetic level using the bidirectional two-sample Mendelian randomization(TSMR), so as to provide new insights for future prevention and treatment strategies for frailty. Methods Genome-wide association study(GWAS)summary data for nine cathepsins(B, E, F, G, H, L2, O, S, and Z)were obtained from the INTERVAL study, which included 3,301 European participants, and GWAS summary data for frailty index were obtained from the meta-analyses including 164,610 UK Biobank and 10,616 Swedish TwinGene participants. TSMR analysis was conducted using inverse variance weighted(IVW)as the primary method, and two regression models, including MR-Egger and weighted median, as the supplementary. In addition, horizontal pleiotropy was tested using the MR-Egger intercept test and MR-pleiotropy residual sum and outliers(MR-PRESSO)analysis, heterogeneity was assessed by applying Cochrans Q test in MR-Egger and IVW methods, and sensitivity analysis was performed using the “leave-one-out” method. Finally, reverse TSMR analysis was used to verify the robustness of the results. Results The forward TSMR analysis corrected by the Bonferroni method revealed a causal relationship between genetically predicted elevated serum cathepsin E level and higher frailty index(β=0.033, 95%CI:0.015-0.050, P<0.001). The reverse TSMR analysis revealed no causal relationship between genetically predicted frailty index and various types of cathepsins(P>0.05/3). The MR-Egger regression model intercept term test, MR-PRESSO Global test and Cochrans Q test showed that the screened single nucleotide polymorphism(SNP)did not have horizontal pleiotropy or heterogeneity. Sensitivity analysis based on the “leave-one-out” method showed that a single SNP did not affect the robustness of the causal association effect values. Conclusion At the genetic level, cathepsin E could potentially serve as a predictive biomarker for susceptibility to frailty, providing new insights for basic and clinical studies of frailty and possible interventions.

Objective To explore the causal relationship between appendectomy and colorectal cancer at the genetic level by a two-sample Mendelian randomization(MR). Methods The analysis was conducted using methods such as inverse variance weighting(IVW), MR Egger, weighted median, and both simple and weighted modes. Using summary data from genome-wide association studies(GWAS), the causal relationship between appendectomy and colorectal cancer was assessed. Sensitivity analyses were performed using leave-one-out analysis, Cochrans Q test, MR-Egger regression intercept test, and MR-PRESSO test to evaluate the heterogeneity, pleiotropy, and stability of the instrumental variables. Results The random-effects IVW results indicated that appendectomy hasd no genetic causal relationship with colorectal cancer(OR=1.13, 95%CI:0.29-4.36, P=0.86). The analysis results from MR Egger, weighted median, simple mode, and weighted mode were consistent with those of the random-effects IVW. There was no heterogeneity, horizontal pleiotropy. The MR analysis results were not influenced by any single SNP. Conclusion There is no causal relationship between appendectomy and colorectal cancer at the genetic level.

Objective To investigate the relationships between short-term exposure to air pollutants and the year of life lost(YLL)due to ischemic stroke, and test the modifying effects of extreme temperature events. Methods Daily ischemic stroke mortality data, meteorological data, and air pollution data were collected from January 1, 2015, to December 31, 2019, in Zibo City. The YLL was calculated using standard life tables. Generalized additive models were adopted to test the effects of air pollutants on YLL. Subgroup analyses were conducted to identify vulnerable population. Stratified analyses were conducted to identify the modifying effects of extreme temperature events. Results PM_2.5 at lag0 and lag01 were significantly associated with an increase of YLL due to ischemic stroke, and for every 10 μg/m³ increase in PM_2.5 concentration, the increases in YLL due to ischemic stroke were 0.56(95%CI: 0.05-1.07)and 0.66(95%CI: 0.06-1.25), respectively. PM₁₀ at lag4, lag01, lag04, and lag05 also showed significant positive associations with YLL due to ischemic stroke, and for every 10 μg/m³ increase in PM₁₀ concentration, increases in YLL due to ischemic stroke were 0.40(95%CI: 0.05-0.75), 0.40(95%CI: 0.01-0.79), 0.67(95%CI: 0.12-1.23)and 0.74(95%CI: 0.13-1.35), respectively. No significant association was observed between O₃, and YLL in the overall population(P>0.05), however, females and those aged ≥ 65 years were more susceptible to O₃, leading to increased YLL in ischemic stroke patients. The associations of SO₂, NO₂, and CO with YLL due to ischemic stroke were not statistically significant(P>0.05). Furthermore, during cold seasons(from October to March each year), cold spells may mask the adverse health effects of PM_2.5. Under a specific cold wave definition, the adverse health effects of PM_2.5 on non-cold spell days were greater than on cold spell days, and this difference was statistically significant(P<0.05). Conclusion Short-term exposure to PM₁₀ and PM_2.5 increases the YLL due to ischemic stroke, and the harmful health effects of PM_2.5 are higher on non-cold spell days. Women and individuals aged ≥ 65 are more susceptible to O₃ exposure. Improving air quality helps prevent premature death due to ischemic stroke, particularly by strengthening protection on non-cold spell days and safeguarding vulnerable populations.

Objective To explore the effect of O₃ exposure on emergency room visits for children with respiratory diseases in Hefei City. Methods Day-by-day data on childrens emergency department visits, air pollutant monitoring data and meteorological data were collected from January 1 2017 to December 31 2019 at a childrens hospital in Hefei City. The effects of different concentrations of O₃ on childrens emergency department visits for respiratory diseases were evaluated based on a distributed lag non-linear model(DLNM), in which the variables such as meteorological factors, temporal trends, and days of the week were adjusted. Results A total of 153,995 emergency room visits for childhood respiratory diseases were included in the study period, and the number of emergency room visits for childhood respiratory diseases increased with the increase of O₃ concentration. Relative to 60 μg/m³, the RR(95%CI)values of single-day lag effects of O₃ concentrations at P25, P50, P75 and P₉₅ on emergency room visits of children were 1.004(1.000-1.008), 1.031(1.016-1.045), 1.062(1.037-1.087)and 1.084(1.053-1.115), respectively, and the RR(95%CI)values of cumulative lag effects were 1.009(1.001-1.013),1.082(1.046-1.119), 1.185(1.112-1.263)and 1.244(1.159-1.336), respectively. Effects of O₃ on emergency room visits for respiratory diseases between boys and girls had no statistically significant different. Among different diseases, the RR values of single-day lag effects of O₃ at concentrations range of P₂₅ to P₉₅ on the number of emergency room visits for acute upper respiratory infection, acute lower respiratory infection and pneumonia were 1.006-1.072, 1.006-1.058 and 1.005-1.060, and the RR values of cumulative lag effects were 1.009-1.223, 1.003-1.359 and 1.017-1.450, respectively. Conclusion Elevated O₃ concentrations in Hefei City may increase the risk of respiratory diseases in children.

Objective To explore the current social adaptation status of the elderly aged 65 and above, and to analyze influencing factors, which would provide theoretical basis and practical guidance for improving the social adaptability of the elderly. Methods Cross-sectional study was adopted in this research. According to the inclusion and exclusion criteria, the elderly aged 65 years and above were selected as the subjects by random sampling method. Questionnaires on influencing factors and social adaptability scale were used to carry out the investigation, including demographic characteristics, living habits, physical health and social support et al. The influence factors of the elderly social adaptation ability were analyzed by univariate statistical analysis and multiple Logistic regression. Results A total of 631 elderly were included in the study, the social adaptation ability score of the elderly was 14(22). The results of Logistic regression analysis showed that the elderly who were male, extroverted, highly educated, participated in physical exercise, vegetarian combination, good sleeping quality and no chronic diseases were more likely to have high social adaptability. Conclusion The elderly should maintain a balanced diet, keep study, and participate in social activities. The community should organize diversified activities and provide psychological counseling. Governments should build barrier-free facilities and provide health education and health services to help the elderly manage chronic diseases. The whole society should work together to improve the quality of life and social adaptability of the elderly.

Objective To conduct a visual analysis of the current state and emerging trends in hospital resilience research. Methods Bibliometric analysis was performed on hospital resilience research data retrieved from the Web of Science and China National Knowledge Infrastructure databases over a decade using CiteSpace software. Results The Web of Science included 1,901 documents, while the China National Knowledge Infrastructure database included 323 documents. The trend in English-language publications initially increased and then declined, whereas the trend in Chinese-language publications began with a slow increase followed by a rapid rise. In terms of core authors, an international core author group had not yet emerged, whereas China had established a distinct group of core authors. Research hotspots in the field of hospital resilience were focused on resilience assessment, governance, lessons learned, and strategic planning. Conclusion The study visually presents the research landscape and trends in hospital resilience, suggesting that future development may involve comprehensive hospital resilience design encompassing pre-disaster preparedness, disaster response, and post-disaster recovery.

Traumatic brain injury represents a significant global public health concern, with its associated acute lung injury gaining increased attention. The pathogenesis of acute lung injury induced by traumatic brain injury is complex, involving multiple factors and mechanisms. Effective management requires a comprehensive understanding of the interplay between traumatic brain injury and acute lung injury. This article summarizes recent advances in understanding how oxidative stress induces damage to the alveolar-capillary barrier, as well as its role in promoting pulmonary inflammation and exacerbating coagulation dysfunction in acute lung injury induced by traumatic brain injury. Additionally, it explores the potential therapeutic effects of agents such as dexmedetomidine, gastrin, polydatin, and enoxaparin, providing a foundation for future clinical strategies aimed at the prevention and treatment of acute lung injury induced by traumatic brain injury. These insights offer valuable theoretical guidance for clinicians in improving patient outcomes.