The incidence and mortality rates of lung cancer in China rank the first of all tumors. At present, there are many effective treatment methods, including surgery, chemotherapy, radiotherapy, targeted therapy, immunotherapy and other local and systematic treatments. In recent years, intratumoral chemotherapy, which combines the advantages of local therapy and systemic therapy, has gradually become the focus. By using ultrasound, bronchoscope, ultrasonic bronchoscope, endoscopic ultrasonography or CT and other imaging and interventional modalities, chemotherapeutics such as cisplatin, carboplatin, mitomycin, paclitaxel liposomes, fluorouracil in stock or diluted solutions are directly injected into the cancer tissue through the puncture needle. Intratumoral chemotherapy can increase the concentration of chemotherapeutics in the tumor tissue, reduce the systemic toxicity and side effects, and improve the local control rate of cancers. We have carried out clinical application and exploratory research on intratumoral chemotherapy for lung cancer, liver metastasis and bone metastasis, and observed patients' benefits and primary efficacy. This paper will summarize the technical procedure of CT-guided intratumoral chemotherapy.
