JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (5): 1-7.doi: 10.6040/j.issn.1671-7554.0.2016.1506

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Effect of Tongxinluo on three-dimensional strain of atherosclerotic vulnerable plaque in rabbits

SONG Yu1, MAO Yang1, LIU Qingmei2, QIAO Lei1, TIE Yuanyuan1, LU Lu3, ZHANG Lei1   

  1. 1. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Second Peoples Hospital of Xintai, Xintai 271200, Shandong, China;
    3. Department of Ultrasound, Fourth Peoples Hospital of Jinan, Jinan 250031, Shandong, China
  • Received:2016-11-15 Online:2017-05-10 Published:2017-05-10

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Abstract: Objective To investigate the effect and possible mechanism of Tongxinluo(TXL)and simvastatin on the three-dimensional strain of atherosclerotic vulnerable plaques. Methods After abdominal aortic balloon injury was induced, 50 male New Zealand rabbits were fed with 1% cholesterol diet for 10 weeks and then randomly assigned into 5 groups for 8-week ordinary treatment: control, low-dose TXL group ［0.15 g/(kg·d)］, moderate-dose TXL group ［0.3 g/(kg·d)］, high-dose TXL group ［0.6 g/(kg·d)］, and simvastatin group ［5 mg/(kg·d)］. At the end of week 18, longitudinal strain(LSp), circumferential(CSp)and radial(RSp)strain of plaques and intravenous 山 东 大 学 学 报 (医 学 版)55卷5期 -宋昱,等.通心络对兔腹主动脉粥样硬化易损斑块中三维应变的影响 \=-ultrasonograph were measured, and blood lipid analysis, pathologic and immunohistochemical staining were performed. Results With the treatment of TXL and simvastatin, CSp and RSp of plaques decreased, whereas LSp increased. Plaque area and burden reduced. Moderate and high dose of TXL and simvastatin intervention could reduce the number of macrophages, vulnerable index and the expressions of matrix metalloproteinase 2(MMP-2)and MMP-9 in plaques. Conclusion TXL and simvastatin modify the three-dimensional strain and enhance the stability of atherosclerotic vulnerable plaques by inhibiting the content of macrophages and expressions of MMP-2 and MMP-9. The plaque-stabilizing effect might be detected by noninvasive three-dimensional strain measurement.

Key words: Tongxinluo, Vulnerable plaque, Three-dimensional strain, Simvastatin, Matrix metalloproteinase

CLC Number: 

  • R541.4
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