JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (5): 49-55.doi: 10.6040/j.issn.1671-7554.0.2017.125

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Correlation between TWEAK and cardiac remodeling in essential hypertensive patients

LI Rui1, MA Weihong1, REN Manyi2, ZHAO Mengmeng1, JIANG Shan1, JU Yuanyuan1, GUO Ying1, SUN Zhaohui1, SUI Shujian1   

  1. 1. Department of Cardiology, Second Hospital of Shandong University, Jinan 250033, Shandong, China;
    2. Department of Cardiology, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2017-02-09 Online:2017-05-10 Published:2017-05-10

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Abstract: Objective To investigate the association between tumor necrosis factor-like weak inducer of apoptosis(TWEAK)and cardiac remodeling in essential hypertensive patients. Methods A total of 88 hypertensive patients enrolled as the hypertension group were divided into two subgroups according to the serum level of soluble TWEAK(sTWEAK): high sTWEAK group(n=51)and low sTWEAK group(n=37). Another 20 healthy subjects served as the control group. The mRNA expression of TWEAK in peripheral blood mononuclear cells(PBMCs)was detected using real-time PCR(RT-PCR). sTWEAK and matrix metalloproteinase 1(sMMP-1)were measured with enzyme linked immunosorbent assay(ELISA). The left atrium diameter(LAD), left atrial volume(LAV), left atrial volume index(LAVI), early wave of mitral flow(E), atrial wave of mitral flow(A), ratio of mitral flow early wave to atrial wave(E/A), and ratio of mitral flow early wave to mitral annular early diastolic velocity(E/E')of mitral valve ring were measured with echocardiography. Results The levels of sTWEAK, TWEAK mRNA and sMMP-1 were higher in 山 东 大 学 学 报 (医 学 版)55卷5期 -李睿,等.TWEAK与原发性高血压患者心脏重塑的相关性 \=-the hypertension group than in the control group(P<0.05), These indexes were significantly greater in the high sTWEAK group than in the low sTWEAK group(P<0.01). LAVI and E/E' were greater in the hypertension group than in the control group(P<0.05), and were significantly greater in the high sTWEAK group than in the low sTWEAK group(P<0.01). Furthermore, the sTWEAK and TWEAK mRNA showed a significant positive correlation with sMMP-1, LAVI and E/E'(P<0.01). Conclusion Cardiac remodeling in essential hypertensive patients might be correlated with up-regulated TWEAK.

Key words: Essential hypertension, Tumor necrosis factor-like weak inducer of apoptosis, Matrix metalloproteinase 1, cardiac remodeling

CLC Number: 

  • R542.2
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