JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (1): 47-53.doi: 10.6040/j.issn.1671-7554.0.2014.485

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Myocardial MMPs and TIMPs mRNA expressions in Chinese population with atrial fibrillation: a Meta-analysis

ZHANG Lingli, ZHOU Ying, LI Xiaohe, LI Hui, ZHONG Ming, ZHANG Wei   

  1. Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-07-23 Revised:2014-11-11 Published:2015-01-10

Abstract: Objective To explore the correlation between myocardial MMPs and TIMPs mRNA levels and Chinese with atrial fibrillation (AF). Methods Databases including Pubmed, Web of Science, CNKI and Wanfang were searched up to May, 2014, to retrieve published studies comparing myocardial mRNA levels of MMPs and TIMPs in Chinese AF patients and sinus rhythm (SR) patients, and then a meta-analysis was conducted. The cardiac tissue samples were obtained from patients who underwent cardiac surgery. Results Altogether 9 studies with AF patients and SR controls were included. The MMP-1 mRNA expression was higher in AF patients than in controls (SMD=0.48, 95% CI: 0.20 to0.76, P<0.01). The MMP-9 mRNA expression was higher in AF patients than in controls (SMD=1.11, 95% CI: 0.75 to 1.46, P<0.01). There was no significant difference in the TIMP-1 and TIMP-2 mRNA expressions between AF patients and controls (SMD=-0.56, 95% CI:-1.77 to 0.65, P=0.37), (SMD=0.31, 95% CI:-1.16 to 1.78, P=0.68). Conclusion Atrial fibrosis increases in atrial fibrillation, and the increased transcript levels of MMP-1 and MMP-9 are associated with the occurrence of atrial fibrillation and remodeling of atrial structure. However, the role of TIMPs is still unclear.

Key words: Matrix metalloproteinases, Atrial fibrillation, Tissue inhibitors of matrix metalloproteinases

CLC Number: 

  • R541
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