JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Expression of calpain-2 in human left atrium in rheumatic atrial fibrillation

HAN Bo1,2, WANG Jianchun2, ZHANG Tao2, ZHU Xiaolong2, LI Cong2, WANG Zhengjun2, ZHAO Yong2, ZOU Chengwei2   

  1. 1. Weifang Medical University, Weifang 261053, Shandong, China;  2. Department of Cardiac Surgery,
    Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2013-11-07 Online:2014-04-10 Published:2014-04-10

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Abstract:  Objective  To observe the expression of calpain-2 in the left atrum of patients with rheumatic atrial fibrillation, and to explore its roles in the pathogenesis of atrial fibrillation. Methods  A total of 39 patients with rheumatic heart disease who received surgical valve replacement were divided into two groups: the atrial fibrillation group (n=23) and sinus rhythm group (n=16). The expression of calpain-2 was detected with LSAB immunohistochemical and the Real-time PCR technology. Results  The deltaCt of calpain-2 mRNA of the atrial fibrillation group (0.091±0.035) was higher than that of the sinus rhythm group (0.066±0.022, P=0.017). Brown particle deposits were observed in the left atrial myocytes in both groups, but the epicardial and endocardial cells showed no brown particles. The average optical density values of calpain-2 of the atrial fibrillation group and sinus rhythm group were (0.92±0.17) and (0.65 ± 0.01)(P<0.001). Calpain-2 levels and left atrial systolic diameter were correlated (r=0.929, P<0.01). Conclusion  Calpain-2 exists in the left atrial myocytes. The expression of calpain-2 increases significantly in case of atrial fibrillation.

Key words: Atrial fibrillation, Cysteine protease, Calpain-2, Calpain inhibitor

CLC Number: 

  • R654.2
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