JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (3): 27-31.doi: 10.6040/j.issn.1671-7554.0.2014.887

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Enhancement of tendon-bone healing by topical use of simvastatin after ACL reconstruction

LIN Jinxiu1, SUN Dongsheng1, ZHENG Xiao1, YIN Dechao1, LI Ye1, ZHANG Lei2   

  1. 1. Department of Orthopedics, First Hospital of Zibo City, Zibo 255200, Shandong, China;
    2. Department of Pathology, First Hospital of Zibo City, Zibo 255200, Shandong, China
  • Received:2014-11-28 Revised:2015-02-08 Online:2015-03-10 Published:2015-03-10

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Abstract: Objective To evaluate the enhancement potential of topical use of simvastatin for tendon-bone healing. Methods A total of 15 rabbits were enrolled to establish anterior cruciate ligament (ACL) reconstruction models. The tibial side was screw fixed while the femoral side was suspending fixed in both knees of the rabbits. Simvastatin was inserted into the left knee (experimental side) bone tunnel with a gelatin sponge carrier, while gelatin sponge was inserted into the right knee (control side) bone tunnel. Three rabbits were sacrificed in week 2, 4 and 8 postoperatively. Tendon-bone interface was histologically assessed. Six rabbits were sacrificed for biomechanical tests in week 8. Results Histological analysis in week 2 demonstrated that tendon-bone healing was significantly greater with angiogenesis in the simvastatin-treated side than in the control side. In week 4, a great quantity of sharpey fibers at tendon-bone interface were observed in the experimental side, yet there were no sharpey fibers in the control side. In week 8, tendon-bone interface was narrow and unclear in the experimental side, yet a few sharpey fibers were observed in the control side. The average load to failure in the experimental side was significantly greater than in the control side. Conclusion Topical use of simvastatin promotes the tendon-bone healing after ACL reconstruction.

Key words: Reconstruction, Simvastatin, Tendon-bone healing, Anterior cruciate ligament

CLC Number: 

  • R686.5
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