JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (5): 95-102.doi: 10.6040/j.issn.1671-7554.0.2016.1196

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Meta-analysis of the association between the STAT4 rs7574865 polymorphism and systemic lupus erythematosus

DU Jinge1, CHEN Hui2, YANG Xiaorong1, LÜ Ming1,2   

  1. 1. Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2016-09-23 Online:2017-05-10 Published:2017-05-10

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Abstract: Objective To assess the association between STAT4 rs7574865 single nucleotide polymorphism and systemic lupus erythematosus by a Meta-analysis. Methods Two authors searched PubMed, Web of science, Scopus, China National Knowledge Infrastructure(CNKI)and Wanfang databases to identify relevant studies, independently. Odds ratio(OR)with 95% confidence interval(CI)were calculated to assess the strength of the association between rs7574865 polymorphism and SLE risk. Results A total of 27 studies were eventually included in this meta-analysis, which contained 21 902 SLE cases and 37 780 controls. Pooled analyses showed significant association between STAT4 rs7574865 polymorphism and SLE risk using allelic model(T vs G, OR=1.56, 95% CI: 1.49-1.63), homozygote model(TT vs GG, OR=2.32, 95% CI: 2.08-2.58), heterozygote model(TG vs GG, OR=1.52, 95% CI: 1.41-1.64), dominant model(TT/TG vs GG, OR=1.67, 95% CI: 1.55-1.79)and recessive model(TT vs TG/GG, OR=1.83, 95% CI: 1.65-2.02). In the subgroup analysis by region, evidences also showed significant association between rs7574865 polymorphism and SLE risk in all regions. Conclusion STAT4 rs7574865 G>T polymorphism correlate with an increased risk of SLE and the T allele may be a risk factor.

Key words: STAT4, Gene polymorphism, Single nucleotide polymorphism, Meta-analysis, Systemic lupus erythematosus

CLC Number: 

  • R181.3
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