JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (9): 65-70.doi: 10.6040/j.issn.1671-7554.0.2014.830

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Comparison of nephron-sparing surgery and radical nephrectomy for T1b renal cell carcinoma: a Meta-analysis

SU Jing1, XUE Jiaomei1, SUN Feifei1, GUO Zhaoxin2, CHENG Xiangyu2, MENG Liwei2, LIU Zhaoxu2   

  1. 1. School of Nursing, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Urology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-11-17 Online:2015-09-10 Published:2015-09-10
  • Contact: 刘照旭。E-mail:zhaoxvliu@sdu.edu.cn E-mail:zhaoxvliu@sdu.edu.cn

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Abstract: Objective To compare the outcomes of nephron-sparing surgery (NSS) and radical nephrectomy (RN) in treating T1b renal cell carcinoma (RCC). Methods The following databases including Pubmed, Elsevier ScienceDirect, Web of Science, Co-chrane library, CNKI, CBM, VIP and WanFang were searched electronically from the date of their establishment to Sept. 2014 to collect cohort studies on NSS versus RN in the treatment of T1b RCC, and the references of those studies were manually retrieved. After the studies were screened according to the inclusion and exclusion criteria, data were extracted and assessed, and Meta-analysis was performed using the Stata 12.0 software. Results A total of 11 studies with 23,939 patients were included. The Results of Meta-analyses showed that, RN and NSS had no significant difference in 5-year[RR=1.05, 95% CI(0.98, 1.13)], 7-year [RR=1.02, 95% CI (0.94, 1.10)], and 10-year [RR=1.30, 95% CI (0.96, 1.77)] overall survival (OS). Nevertheless, NSS had higher 5-year cancer specific survival (CSS) [RR=1.11, 95% CI (1.06, 1.16)], lower 5-year cancer specific mortality (CSM) [RR=0.70, 95% CI (0.55, 0.90)] and lower metastasis rate [RR=0.38, 95% CI(0.22, 0.66)]. Conclusion For the patients who are included in the study, NSS and RN is comparable in 5-year OS, 7-year OS, 10-year OS; NSS is superior to RN in 5-year CSS, 5-year CSM and metastasis rate.

Key words: T1b RCC, Prognosis, Radical nephrectomy, Nephron-sparing surgery, Meta-analysis

CLC Number: 

  • R737.11
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