Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (9): 45-51.doi: 10.6040/j.issn.1671-7554.0.2020.0367

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Identification of FKBP11 expression in clear cell renal cell carcinoma using bioinformatics analysis

LI Yinglin1,2, SONG Daoqing3, XU Zhonghua1   

  1. 1. Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Urology, Gunxian Peoples Hospital, Guanxian 252500, Shandong, China;
    3. Department of Urology, Kunshan Rehabilitation Hospital, Kunshan 215300, Jiangsu, China
  • Online:2020-09-10 Published:2020-08-30

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Abstract: Objective To explore the expression of FK506 binding protein 11(FKBP11)in clear cell renal cell carcinoma(ccRCC), and to analyze its correlation with the clinicopathological features of ccRCC. Methods Based on Ualcan, GEPIA and HPA databases, the mRNA and protein expressions of FKBP11 in ccRCC, their correlation with the clinicopathological features of ccRCC, and their effects on the prognosis of patients were analyzed. Results The mRNA expression of FKBP11 was higher in ccRCC tissues than in normal kidney tissues. Analysis of Ualcan database showed differences in FKBP11 expression between normal kidney tissues and Grade 1(P=5.78E-051), Grade 2(P=1.62E-12), Grade 3(P=1.11E-16)and Grade 4(P=1.63E-12)ccRCC. The expression differences between normal and ccA and ccB subtypes were both P=1.62E-12. There were differences between normal and N0(P<1E-12)and N1(P=8.26E-05)subtypes in TNM staging. With higher ccRCC pathological grading, the expression of FKBP11 was up-regulated and related to the progression of ccRCC. However, there were no differences among different age, sex and race groups(P>0.05). There was difference in the overall survival rate between patients with high and low expressions of FKBP11(P<0.01). Conclusion Bioinformatics analysis indicated that FKBP11 was highly expressed in ccRCC, and there were differences in FKBP11 expressions among different stages, pathological grades and subtypes of ccRCC. Poorer pathological grades and stages of ccRCC showed higher expression of FKBP11, and high expression of FKBP11 indicated poorer prognosis.

Key words: FK506-binding protein-11, Clear cell renal cell carcinoma, Bioinformatics, Prognosis

CLC Number: 

  • R737.11
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