JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (4): 55-59.doi: 10.6040/j.issn.1671-7554.0.2016.1285

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Clinical value of PNI and HGB in evaluating the prognosis of the middle to late stage non-small cell lung cancer patients

SUN Qijing1, CHEN Fangfang2, LI Chunxiao3, ZHANG Caiqing2   

  1. 1. Medical College of Shandong University, Jinan 250012, Shandong, China;
    2. Respiratory Physicians of Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China;
    3. Medical College of Taishan, Taian 271000, Shandong, China
  • Received:2016-10-11 Online:2017-04-10 Published:2017-04-10

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Abstract: Objective To explore the clinical value of prognosis of nutrition index(PNI)and hemoglobin(HGB)in evaluating the prognosis of the middle to late stage non-small cell lung cancer patients. Methods A total of 120 cases of the middle to late stage non-small cell lung cancer patients were selected during August 2013 and August 2015. The clinical information and data of all patients were collected when they were first confirmed. All patients were followed-up by the date of death or August 2016 through electronic medical record system, outpatient and telephone, etc. The patients were divided into high and low PNI groups, and high and low HGB groups on the basis of the medians of PNI(46.52)and HGB(115 g/L). The impact of PNI and HGB on overall survival(OS)of patients was analyzed through single factor and multiple factors methods. The survival curves of two groups were produced by Kaplan-Meier method. The Log-rank test was exerted. The related influencing factors of PNI and HGB were analyzed through single factor method. Results The single factor analysis showed that the patients with age≥65 years, smoking index≥400, PNI<46.52, HGB<115 g/L when they were first confirmed had significantly lower OS than those with age<65 years, 山 东 大 学 学 报 (医 学 版)55卷4期 -孙启晶,等.PNI及HGB评估中晚期非小细胞肺癌患者预后的临床价值 \=-smoking index<400, PNI≥46.52, HGB≥115 g/L(P<0.05). PNI were closely related to the age, clinical stages, pleural effusion and smoking index(P<0.05). HGB were closely related to the age and weight loss rate(P<0.05). The multiple factors analysis showed that only PNI and HGB were statistically significant on OS of the patients［Exp(B)=2.180, P<0.001; Exp(B)=2.032, P=0.001］. The survival curves and Log-rank test showed that low PNI and HGB groups had lower OS than high PNI and HGB groups(P<0.001). Conclusion PNI and HGB can be used as the independent risk factors for the middle to late stage non-small cell lung cancer patients.

Key words: Risk factors, Prognosis of nutrition index, Hemoglobin, Non-small cell lung cancer, Prognostic

CLC Number: 

  • R734
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