JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (1): 63-66.doi: 10.6040/j.issn.1671-7554.0.2014.652

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Correlation between the expressions of Runx2 and Ezrin and postoperative metastasis in patients with stage IB non-small cell lung cancer

GAO Peng, SHEN Fangzhen, XIAO Wenjing, XIU Yuande, ZHOU Lingling   

  1. Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China
  • Received:2014-09-28 Revised:2014-12-01 Published:2015-01-10

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Abstract: Objective To explore the expressions of runt-related transcription factor 2 (Runx2) and Ezrin gene in stage IB non-small cell lung cancer (NSCLC) and to investigate their relationship with postoperative recurrence and metastasis. Methods Forty resected IB stage NSCLC tissues were divided into the recurrence/metastasis group with postoperative recurrence (n=20) and control group without postoperative recurrence (n=20). Immunohistochemical method was used to detect the expressions of the Runx2 and Ezrin genes. The correlation between the gene expressions and disease free survival rate of patients with stage IB NSCLC were analyzed by Kaplan-Meier. Results The positive rates of Runx2 and Ezrin expressions in the recurrence/metastasis group were significantly higher than the control group (P=0.004, P=0.011). The positive expressions of Runx2 and Ezrin in the low differentiated tissues were higher than those in the moderate and high differentiated tissues (P=0.016, P=0.009). There was a positive correlation between Runx2 and Ezrin expression (r=0.646, P=0.001). The three-year disease free survival rate was lower in patients with Runx2 and Ezrin positive expressions (30.4% and 31.8%) than those with negative expressions (76.5% and 72.2%) (P=0.010, P=0.011). Conclusion Runx2 and Ezrin expressions are closely corelative to postoperative recurrence and metastasis in patients with stage IB NSCLC, and might be potential prognostic markers in stage IB NSCLC.

Key words: Runt-related transcription factor 2, Ezrin, Non-small cell lung cancer, Neoplasm metastasis

CLC Number: 

  • R734.2
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