JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (10): 84-89.doi: 10.6040/j.issn.1671-7554.0.2017.167

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Association between high expression of scavenger receptor class B type I and the prognosis of colon cancer

LIU Huiling1, WANG Xingwen1, FENG Shaobin2, FENG Hong1, HAN Junqing1   

  1. 1. Cancer Center, Shandong Provincial Hospital Affiliated of Shandong University;
    2. Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2017-02-23 Online:2017-10-10 Published:2017-10-10

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Abstract: Objective To explore the association between the expression of scavenger receptor class B type I(SR-BI)and the clinicopathological variables, and to determine whether SR-BI expression was an independent prognostic factor and a potential therapeutic target for colon cancer. Methods A well-documented tissue microarray of 90 patients with colon cancer was purchased from Shanghai Outdo Biotech Co., Ltd. The SR-BI expression in the cancer tissues and para-cancerous tissues were detected with immunohistochemical method. The association between SR-BI expression and the clinicopathological variables, and patients outcome was analyzed. Results In 78.9% of the cases, SR-BI expression was higher in the cancer tissues than in the adjacent non-tumor tissues(P<0.001). The expression of SR-BI in colon cancer tissues had no significant statistical association with the clinicopathological variables. Patients with low SR-BI expression in colon cancer tissues had a shorter overall survival(OS)than those with high SR-BI expression(P=0.042). The multivariate analysis confirmed that high SR-BI expression was an independent favorable prognostic factor for OS(P=0.039). Conclusion Low SR-BI expression is associated with unfavorable prognosis of colon cancer. SR-BI is an independent prognostic factor of colon cancer.

Key words: Colon cancer, Prognosis, Scavenger receptor class B type I, Immunohistochemistry

CLC Number: 

  • R735.3
[1] Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015 [J]. CA Cancer J Clin, 2016, 66(2):115-132.
[2] Vargas AJ, Thompson PA. Diet and nutrient factors in colorectal cancer risk [J]. Nutr Clin Pract, 2012, 27(5): 613-623.
[3] Barone M, Lofano K, De Tullio N, et al. Dietary, endocrine and metabolic factors in the development of colorectal cancer [J]. J Gastrointest Cancer, 2012, 43(1): 13-19.
[4] Ruder EH, Thiebaut AC, Thompson FE, et al. Adolescent and mid-life diet: risk of colorectal cancer in the NIH-AARP diet and health study [J]. Am J Clin Nutr, 2011, 94(6):1607-1619.
[5] Liao F, He W, Xia L, et al. A high LDL-C to HDL-C ratio predicts poor prognosis for initially metastatic colorectal cancer patients with elevations in LDL-C [J]. Onco Targets Ther, 2015, 8: 3135-3142. doi: 10.2147/OTT.S90479.
[6] Shen WJ, Hu J, Salman Azhar, et al. Scavenger receptor class B type I(SR-BI): a versatile receptor with multiple functions and actions [J]. Metabolism, 2014, 63(7): 875-886.
[7] Pelton K, Freeman MR, Solomon KR. Cholesterol and prostate cancer [J]. Curr Opin Pharmacol, 2012, 12(6): 751-759.
[8] 李文燕, 刘洪涛, 王瑞芝. B 类Ⅰ型清道夫受体SR-BI表达上调剂的研究进展[J]. 沈阳药科大学学报, 2016, 33(6): 507-511.
[9] Danilo C, Gutierrez-Pajares JL, Frank PG, et al. Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development [J]. Breast Cancer Res, 2013, 15(5): R87.
[10] Zheng Y, Liu Y, Zhang Z, et al. Scavenger receptor B1 is a potential biomarker of human nasopharyngeal carcinoma and its growth is inhibited by high-density lipoprotein-mimetic nanoparticles [J]. Theranostics, 2013, 3(7):477-486.
[11] Muntoni S, Atzori L, Mereu R, et al. Serum lipoproteins and cancer [J]. Nutr Metab Cardiovasc Dis, 2009, 19(3): 218-225.
[12] Jacobs EJ, Stevens VL, Gapstur SM, et al. Plasma total, LDL, and high-density lipoproteincholesterol and risk of aggressive prostate cancer in the Cancer Prevention Study II Nutrition Cohort [J]. Cancer Causes Control, 2012, 23(8): 1289-1296.
[13] Cruz P, Mo H, Lacko A, et al. The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics[J]. Front Pharmacol, 2013, 4(119): 3389-3396.
[14] Huang LZ, Gao JL, Zhang Y, et al. Apolipoprotein M: research progress, regulation and metabolic functions [J]. Mol Med Rep, 2015, 12(2): 1617-1624.
[15] Yao X, Tian Z. Dyslipidemia and colorectal cancer risk: a meta-analysis of prospective studies [J]. Cancer Causes Control, 2015, 26(2): 257-268.
[16] Davis Yadley AH, Lipka S, Pan Q, et al. Ethnic disparities in the risk of colorectal adenomas associated with lipid levels: a retrospective multiethnic study [J]. J Gastrointest Cancer, 2015, 46(1): 29-35.
[17] Zhang X, Zhao XW, Wang Y, et al. Lipid levels in serum and cancerous tissues of colorectal cancer patients [J]. World J Gastroenterol, 2014, 20(26): 8646-8652.
[18] Borgquist S, Butt T, Melander O, et al. Apolipoproteins, lipids and risk of cancer[J]. Int J Cancer, 2016, 138(11): 2648-2656.
[19] Chandler PD, Song Y, Ridker PM, et al. Lipid biomarkers and long-term risk of cancer in the Womens Health Study [J]. Am J Clin Nutr, 2016, 103(6): 1397-1407.
[20] Coppola JA, Shrubsole MJ, Murff HJ, et al. Plasma lipid levels and colorectal adenoma risk [J]. Cancer Causes Control, 2015, 26(4):635-643.
[21] Wang Y, Wang ZQ, Li YH, et al. Predictive value of chemotherapy-related high-density lipoprotein cholesterol(HDL)elevation in patients with colorectal cancer receiving adjuvant chemotherapy: an exploratory analysis of 851 cases [J]. Oncotarget, 2016, 7(35):57290-57300.
[22] 李传凤,李军,白鹏,等.结直肠腺瘤与患者血脂代谢水平[J]. 北京大学学报(医学版),2011,43(3):432-435. LI Chuanfeng, LI Jun, BAI Peng, et al. Characteristic analysis of plasma lipid metabolism level in patients withcolorectal adenoma[J]. Journal of Peking University(Health Science), 2011, 43(3): 432-435.
[23] 申光哲, 金头峰. 结直肠癌与代谢综合征的相关性[J]. 延边大学医学学报, 2015, 38(1): 25-27.
[24] Cruz PM, Mo H, McConathy WJ, et al. The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics [J]. Front Pharmacol, 2013, 4: 119. doi: 10.3389/fphar.2013.00119.
[25] Su F, Grijalva V, Navab K, et al. HDL mimetics inhibit tumor development in both induced and spontaneous mouse models of colon cancer [J]. Mol Cancer Ther, 2012, 11(6): 1311-1319.
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