JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (8): 61-65.doi: 10.6040/j.issn.1671-7554.0.2017.105

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Expression and clinical significance of angiopoietin-like protein 5 in human gastric cancer tissues

NIE Siyue1, WANG Zhen2, SUN Jingyu3, LIU Jie1, LI Juan1, WEI Xiaojuan1, LU Chunxiao4, L(¨overU)Xingyan4, WANG Shuyun1, SUN Yuping1   

  1. 1. Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    2. Department of Chemotherapy, Peoples Hospital of Zhangqiu, Jinan 250200, Shandong, China;
    3. School of Life Science, Shandong University, Jinan 250100, Shandong, China;
    4. Weifang Medical University, Weifang 261053, Shandong, China
  • Received:2017-01-26 Online:2017-08-10 Published:2017-08-10

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Abstract: Objective To investigate the expression of angiopoietin-like protein 5(ANGPTL5)and its clinical significance in primary human gastric cancer(GC). Methods Using immunohistochemistry(IHC), the expression of ANGPTL5 protein in 73 human specimens was detected including GC tissues and adjacent normal tissues. Pearson Chi-square test and continuity correction for Pearson Chi-square test were used to analyze the difference of ANGPTL5 expression between cancer tissues and adjacent normal tissues and the association between clinical pathological parameters and ANGPTL5 expression in GC tissues. Results ANGPTL5 was mainly expressed in cytoplasm of GC cells, and faint staining was presented in parts of interstitial cells, but most of adjacent normal gastric cells had no or little ANGPTL5 expression. A significant overexpression of ANGPTL5 protein was presented in GC tissues compared with that in adjacent normal tissues(χ2=38.939,P<0.001). Moreover, ANGPTL5 expression was significantly associated with primary tumor size(χ2=5.006, P=0.025), depth of tumor infiltration(χ2=6.810, P=0.009)and TNM stages(χ2=4.867, P=0.027). Furthermore, the overall survival(OS)in ANGPTL5 positive group was lower than that in the negative group(χ2=5.888,P=0.015). Conclusion ANGPTL5 was highly expressed in GC tissues, which was 山 东 大 学 学 报 (医 学 版)55卷8期 -聂思月,等.ANGPTL5在人胃癌组织中的表达及临床意义 \=-associated with poorly prognostic factors and shorter OS, suggesting that ANGPTL5 may be involved in GC progression, and it might be a new potential poor prognostic indicator for GC treatment.

Key words: Clinical characteristics, Overall survival, Angiopoietin-like protein 5, Gastric neoplasms, Immunohistochemistry

CLC Number: 

  • R735.2
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