JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (6): 68-72.doi: 10.6040/j.issn.1671-7554.0.2014.617

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Expression and clinical significance of NPRL2 and Survivin in hepatocellular carcinoma

GU Xu1, WANG Xiaqing2, REN Wanhua1, QIN Chengyong1, HAN Guoqing1   

  1. 1. Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    2. Department of Gastroenterology, Qingdao Eighth People's Hospital, Qingdao 266000, Shandong, China
  • Received:2014-09-17 Revised:2015-03-19 Published:2015-06-10

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Abstract: Objective To investigate the expressions of NPRL2 and Survivin, and their association with the clinicopathologic parameters of hepatocellular carcinoma (HCC). Methods A total of 45 HCC tissues, paracancerous liver tissues and 15 normal liver tissues were collected. Expressions of NPRL2 and Survivin were determined with immunohistochemistry and RT-PCR methods. Results Compared with paracancerous liver tissues and normal liver tissues, HCC tissues had higher Survivin expression but lower NPRL2 expression (P<0.01), but no significant differences were found between paracancerous liver tissues and normal liver tissues (P>0.05). NPRL2 expression was significantly related to TNM stage (P<0.05). Survivin expression was associated with serum AFP concentration and TNM stage (P<0.05). By spearman relative analysis, there was significant correlation between NPRL2 mRNA and Survivin mRNA (r=-0.45, P<0.01). Conclusion In hepatocellular carcinoma, anti-oncogene NPRL2 was negatively related to oncogene Survivin. The two genes may play important roles in the occurrence and development of hepatocellular carcinoma.

Key words: NPRL2, Survivin, Immunohistochemistry, RT-PCR, Hepatocellular carcinoma

CLC Number: 

  • R735.7
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