JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (7): 82-86.doi: 10.6040/j.issn.1671-7554.0.2014.864

Previous Articles     Next Articles

Expressions of PDCD4 and survivin in condyloma acuminatum, Bowenoid papulosis, Bowen disease and squamous cell carcinoma

YU Shuping1, LI Xuefei1, WANG Dan1, WANG Yukun2   

  1. 1. Department of Dermatology, Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei, China;
    2. Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-11-24 Revised:2015-03-12 Published:2015-07-10

PDF (PC)

79

Abstract: Objective To explore the expressions of programmed cell death 4 (PDCD4) and survivin in patients with condyloma acuminatum (CA), Bowenoid papulosis (BP), Bowen disease (BD) and squamous cell carcinoma (SCC). Methods The expressions of PDCD4 and survivin were detected in normal foreskin (n=10), CA (n=30), BP (n=28), BD (n=10) and SCC (n=11) with immunohistochemical techniques. Results The expression of PDCD4 in BP, BD and SCC was significantly lower than that in foreskin control (P<0.05), and it was lower in SCC than in CA (P<0.05). The expression of survivin in both BD and SCC was significantly higher than that in control (P<0.05), and it was higher in SCC than in CA (P<0.05). Conclusions PDCD4 can inhibit benign neoplasms from malignant transformation. The overexpression of survivin can inhibit cell apoptosis and promote proliferation.

Key words: Programmed cell death, Squamous cell carcinoma, Survivin, Conduloma acuminatum, Bowenoid papulosis, Bowen Disease

CLC Number: 

  • R739.5
[1] Chang KH, Miller N, Kheirelseid EA, et al. MicroRNA21 and PDCD4 expression in colorectal cancer[J]. Eur J Surg Oncol, 2011, 37(7):597-603.
[2] 杨飞, 邓跃华, 刘弋, 等. 胃癌中MTDH与PDCD4的表达及其临床意义[J]. 安徽医科大学学报, 2014, 49(7):954-957. YANG Fei, DENG Yuehua, LIU Yi, et al. Expression and clinical significance of MTDH and PDCD4 in gastric cancer[J]. Acta Universitatis Medicinalis Anhui, 2014, 49(7):954-957.
[3] 席乐峰, 杨廷桐, 常晓宾, 等. 微小RNA-21和程序性细胞死亡因子4在非小细胞肺癌组织中的表达及意义[J]. 现代预防医学, 2014, 41(15):2814-2818. XI Lefeng, YANG Tingtong, CHANG Xiaobin, et al. Expression and significance of MicroRNA-21 and PDCD4 in NSCLC[J]. Modern Preventive Medicine, 2014, 41(15):2814-2818.
[4] 刘力山, 刘丽霞, 杨秋丽, 等. PTEN和PDCD4在上皮性卵巢癌中的表达及意义[J]. 国际检验医学杂志, 2013, 34(12):1527-1530. LIU Lishan, LIU Lixia, YANG Qiuli, et al. Expression of PTEN and PDCD4 protein in ovarian epithelial cancer and its significance[J]. International Journal of Laboratory Medicine, 2013, 34(12):1527-1530.
[5] Shibahara K, Asano M, Ishida Y, et al. Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death[J]. Gene, 1995, 166:297-301.
[6] Goke A, Goke R, Knolle A, et al. DUG is a novel homologue of translation initiation factor 4G that binds Eif4A[J]. Biochem Biophys Res Commun, 2002, 297(1):78-82.
[7] Onishi Y, Hashimoto S, Kizaki H. Cloning of the TIS gene suppressed by topoisomerase inhibitors[J]. Gene, 1998, 215(2):453-459.
[8] 鹿慧, 王斌全, 李建民, 等. PDCD4 及CDKN1A/p21 在喉鳞状细胞癌中的表达及临床意义[J/CD]. 中华临床医师杂志, 2014, 8(9):1606-1609. LU Hui, WANG Binquan, LI Jianmin, et al. Expression and clinical significance of PDCD4 and CDKN1A/P-21 in laryngeal squamous cell carcinoma[J]. Chinese Journal of clinicians, 2014, 8(9):1606-1609.
[9] 王建亭, 张玉祥. 程序性细胞死亡因子4蛋白表达与喉鳞状细胞癌相关性研究[J]. 临床耳鼻咽喉头颈外科杂志, 2011, 25(12):539-541. WANG Jianting, ZHANG Yuxiang. Expression of programmed cell death 4 protein is closely correlated with laryngeal squamous cell carcinomas[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2011, 25(12):539-541.
[10] 马刚, 张浩, 董明, 等. 程序性细胞死亡因子4在大肠癌组织中表达的临床病理学意义及其与预后的关系[J]. 中华普通外科杂志, 2007, 22(1):67-68. MA Gang, ZHANG Hao, DONG Ming, et al. Clinical pathological significance of programmed cell death 4 expression in carcinoma of large intestine and correlation with prognosis[J]. Chinese Journal of General Surgery, 2007, 22(1):67-68.
[11] Bohm M, Sawicka K, Siebrasse JP, et al. The transformation suppressor protein PDCD4 shuttles between nucleus and cytoplasm and binds RNA[J]. Oncogene, 2003, 22(31):4905-4910.
[12] Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin.expressed in cancer and lymphoma[J]. Nature Med, 1997, 3(8):917-921.
[13] Park HR, Min SK, Cho HD, et al. Expression profiles of p63, p53, survivin, and hTERT in skin tumors[J]. J Cutan Pathol, 2004, 31(8):544-549.
[14] Kawasaki H, Toyoda M, Shinohara H, et al. Expression of surviving correlates with apoptosis, proliferation, and angiogenesis during human colorectal tumorigenesis[J]. Cancer, 2001, 91(11):2026-2032.
[15] Dallaglio K, Petrachi T, Marconi A, et al. Expression of nuclear survivin in normal skin and squamous cell carcinoma:a possible role in tumour invasion[J]. Br J Cancer, 2014, 110(1):199-207.
[1] HUANG Fang, KANG Rui, TUN Chun-Lin. Expressions of VEGF-C，nuclear factor-kappa B and  Survivin in nasopharyngeal carcinoma and their clinical implications [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 83-.
[2] WANG Lin-Lin, SUN Mei-Li, SUN Yu-Ping, ZHANG Nan, LIU Chuan-Yong. Expressions of α-Tubulin and γ-Tubulin in human Glioma and their relation with Survivin [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 103-.
[3] MENG Zhaotun, LI Qin, SUN Hui, WU Xinfang, SUN Wenkai, GAO Wei. Correlation between interleukin-18 single nucleotide polymorphism and susceptibility of laryngeal squamous cell carcinoma: a report of 73 cases [J]. Journal of Shandong University (Health Sciences), 2020, 1(9): 58-63.
[4] LI Xingkai, LIU Zhanye, JIANG Yunfeng, LI Jun. Clinicopathological factors and prognosis between primary central and peripheral lung squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(9): 73-78.
[5] WU Lukanxuan, ZHU Shan, YU Jinxi, LÜ Chunzi, LI Mingjiang. Expression and significance of programmed death-1 and its ligand PD-L1 in adenomyosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 90-96.
[6] MA Xue, ZHANG Bin, HAN Chunyao, LIU Mingyuan, HAO Lijing, GE Shuqing, XUE Zhongyuan. Down-regulation of α-catulin inhibits the invasion and migration of human tongue squamous cancer cell line Tscca in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 12-15.
[7] WEI Xiujuan, WU Xiuyin, TONG Dongdong, LI Jing, YANG Xiaolu, ZHANG Fenghe. Expression of BDNF/TrkB and effect of BDNF on the proliferation ability of tongue squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 50-54.
[8] ZENG Renren, ZHANG Junhua, ZHANG Yinxu. The role of miR-485-5p in human colorectal cancer HCT116 cell invasion by regulating survivin expression [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(6): 23-27.
[9] GU Xu, WANG Xiaqing, REN Wanhua, QIN Chengyong, HAN Guoqing. Expression and clinical significance of NPRL2 and Survivin in hepatocellular carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(6): 68-72.
[10] LI Hongxia, DONG Lei, JIANG Jiong, WANG Xinyang. Effects of peptide YY on apoptosis of human pancreatic cancer cell line Miapaca-2 in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(12): 7-11.
[11] JIANG Chunfan, ZHANG Qin, LIANG Jinjun, WANG Guiying, FU Wenrong. IgG expression in laryngeal squamous cell carcinoma and its clinical significance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(11): 25-31.
[12] MA Honghai, DU Jiajun. Comparison of treatment outcomes after two different surgical approaches for operable middle thoracic esophageal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(1): 67-72.
[13] DONG Zhaojing, SHANG Qianwen, GUO Chun, ZHANG Lining, WANG Qun . Effect of PDCD4 siRNA on the lipid accumulation in macrophages#br# [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(4): 18-21.
[14] WU Jinhua1, YANG Xihu1, LIU Zhenzhong2, DING Xiaojun1, XU Jianhui1. Expression  and significance of Survivin in human oral squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(4): 89-92.
[15] WANG Hua-chun1, HUANG Sheng-yun2, XIE Hong-jun1, LIU Wen-lei1, ZHANG Jie3, ZHANG Dong-sheng1,2. Expression and clinical significance of protein tyrosine phosphatase SHP-2 in oral squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(2): 82-85.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd