JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (7): 87-91.doi: 10.6040/j.issn.1671-7554.0.2015.138

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Clinico-pathological characteristics and diagnostic biomarkers in patients with esophageal carcinoma accompanied by neuroendocrine cell differentiation

LIU Lianke1, SHAO Mingwen2, MA Lan1, SUN Jing1, GUAN Dan1, SHU Yongqian1   

  1. 1. Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China;
    2. Department of Internal Medicine, Jiangsu Armed Police General Hospital, Yangzhou 225003, Jiangsu, China
  • Received:2015-02-03 Revised:2015-05-20 Published:2015-07-10

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Abstract: Objective To investigate the clinico-pathological characteristics and diagnostic markers in esophageal carcinoma accompanied by neuroendocrine cell differentiation (E-NED). Methods The clinico-pathological data of 378 patients with poorly differentiated esophageal carcinoma from Jan. 2008 to Dec. 2013, including 349 without neuroendocrine differentiation (E-NNED) and 29 with neuroendocrine differentiation (E-NED), were retrospectively analyzed. The expressions of synaptophysin (SYN), chromogranin A (CgA), neuron-specific enolase (NSE), neural cell adhesion molecule (CD56), protein gene product (PGP9.5), secretagogin (SCGN) and thyroid transcription factor 1 (TTF-1) in the esophageal carcinoma tissues of 29 patients with E-NED and 20 ones randomly selected from the 349 patients with E-NNED were detected using immunohistochemistry. Results There were no significant differences between the patients with E-NED and E-NNED in terms of the age, gender, length of lesion and other clinico-pathological factors. Except for TTF-1, the expressions of Syn, CgA, NSE, CD56, PGP9.5 and SCGN were significantly higher in patients with E-NED than those with E-NNED (P<0.05). The sensitivity, positive predictive value anddiagnostic accuracy were all higher in the combined detection of Syn and CD56, PGP9.5 or SCGN than Syn and CgA (P<0.05). There were no significant differences between the patients with E-NED and E-NNED regarding 1, 2 and 3-year survival rates. Conclusion E-NED and E-NNED may be different pathological types of esophageal carcinoma. Both PGP9.5 and SCGN can be considered as the diagnostic markers of E-NED, and the combined detection of Syn and CD56, PGP9.5 or SCGN can improve the sensitivity and diagnostic accuracy.

Key words: Esophageal carcinoma, Neuroendocrine cell differentiation, Secretagogin, Prognosis, Synaptophysin, Neural cell adhesion molecule, Protein gene product 9.5

CLC Number: 

  • R735.1
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