JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (4): 46-50.doi: 10.6040/j.issn.1671-7554.0.2015.1158

Previous Articles     Next Articles

Prognostic hematological biomarkers of amyotrophic lateral sclerosis

MA Lin, ZHANG Dong, TANG Lei, YE Siyuan, YAN Chuanzhu, CAO Lili   

  1. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shangdong, China
  • Received:2015-11-24 Online:2016-04-10 Published:2016-04-10

PDF (PC)

308

Abstract: Objective To investigate the relationship between some of hematological factors and the prognosis of amyotrophic lateral sclerosis(ALS), and search for hematology markers which could predict the prognosis of patients with ALS. Methods The retrospective study included 116 patients with ALS from the Qilu Hospital of Shandong University during January 2007 to December 2012. Their clinical data and routine hematological parameters were collected. Survival of patients was calculated by using the Kaplan-Meier method. The relationship between levels of hematological parameters and the survival curve of patients were analyzed by Log-rank test. Multivariate effect on survival time was analyzed with Cox proportional hazard model. Results The survival increased in patients with higher levels of serum albumin, creatinine(sCr), triglyceride(TG), lowdensity lipoprotein/ high density lipoprotein(LDL/HDL)or uric acid(UA). Moreover, a dose-response effect was found only in sCr and TG(P<0.05). Multivariable analysis showed that only sCr was an independent hematological marker affecting the prognosis of patients with ALS. Conclusion Blood lipid level and nutritional status are associated with survival of ALS patients, and sCr can be used as a potential independent prognostic biomarker of ALS.

Key words: Amyotrophic lateral sclerosis, Hematological parameter, Serum creatinine, Prognosis

CLC Number: 

  • R741
[1] Chio A, Logroscino G, Hardiman O, et al. Prognostic factors in ALS: a critical review[J]. Amyotroph Lateral Scler, 2009, 10(5-6): 310-323.
[2] Chiò A, Calvo A, Bovio G, et al. Amyotrophic lateral sclerosis outcome measures and the role of albumin and creatinine: a population-based study[J]. JAMA Neurol, 2014, 71(9): 1134-1142.
[3] Dorst J, Kuhnlein P, Hendrich C, et al. Patients with elevated triglyceride and cholesterol serum levels have a prolonged survival in amyotrophic lateral sclerosis[J]. J Neurol, 2011, 258(4): 613-617.
[4] Ikeda K, Hirayama T, Takazawa T, et al. Relationships between disease progression and serum levels of lipid, urate, creatinine and ferritin in Japanese patients with amyotrophic lateral sclerosis: a cross-sectional study[J]. Intern Med, 2012, 51(12): 1501-1508.
[5] Zoccolella S, Simone IL, Capozzo R, et al. An exploratory study of serum urate levels in patients with amyotrophic lateral sclerosis[J]. J Neurol, 2011, 258(2):238-243.
[6] Brooks BR, Miller RG, Swash M, et al. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis[J]. Amyotroph Lateral Scler Other Motor Neuron Disord, 2000, 1(5): 293-299.
[7] Korner S, Hendricks M, Kollewe K, et al. Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis(ALS): impact on quality of life and therapeutic options[J]. BMC Neurol, 2013, 13:84. doi: 10.1186/1471-2377-13-84.
[8] Kerentz AJ, Williams AC, Nattrass M. Abnomal regulation of carbohydrate metabolism in motor neurone disease[J]. Diabetes Res, 1991, 16(2): 93-99.
[9] Dupuis L, Oudart H, René F, et al. Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model[J]. Proc Natl Acad Sci U S A, 2004, 101(30): 11159-11164.
[10] Thau N, Knippenberg S, Korner S, et al. Decreased mRNA expression of PGC-1alpha and PGC-1alpha-regulated factors in the SOD1G93A ALS mouse model and in human sporadic ALS[J]. J Neuropathol Exp Neurol, 2012, 71(12): 1064-1074.
[11] Barroso E, Rodriguez-Calvo R, Serrano-Marco L, et al. The PPARbeta/delta activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1alpha-Lipin 1-PPARalpha pathway leading to increased fatty acid oxidation[J]. Endocrinology, 2011, 152(5): 1848-1859.
[12] Paganoni S, Deng J, Jaffa M, et al. Body mass index, not dyslipidemia, is an independent predictor of survival in amyotrophic lateral sclerosis[J]. Muscle Nerve, 2011, 44(1): 20-24.
[13] Jawaid A, Murthy SB, Wilson AM, et al. A decrease in body mass index is associated with faster progression of motor symptoms and shorter survival in ALS[J]. Amyotroph Lateral Scler, 2010, 11(6): 542-548.
[14] Reich-Slotky R, Andrews J, Cheng B, et al. Body mass index(BMI)as predictor of ALSFRS-R score decline in ALS patients[J]. Amyotroph Lateral Scler Frontotemporal Degener, 2013, 14(3): 212-216.
[15] Edwards IR, Star K, Kiuru A. Statins, neuromuscular degenerative disease and an amyotrophic lateral sclerosis-like syndrome: an analysis of individual case safety reports from vigibase[J]. Drug Saf, 2007, 30(6): 515-525.
[16] Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism[J]. Physiol Rev, 2000, 80(3): 1107-1213.
[17] Hashizume A, Katsuno M, Banno H, et al. Longitudinal changes of outcome measures in spinal and bulbar muscular atrophy[J]. Brain, 2012, 135(pt 9): 2838-2848.
[18] Reynolds A, Laurie C, Lee Mosley R, et al. Oxidative stress and the pathogenesis of neurodegenerative disorders[J]. Intern Rev Neurobiol, 2007, 82: 297-325.
[19] Du Y, Chen CP, Tseng CY, et al. Astroglia-mediated effects of uric acid to protect spinal cord neurons from glutamate toxicity[J]. Glia, 2007, 55(5): 463-472.
[20] Weisskopf MG, OReilly E, Chen H, et al. Plasma urate and risk of Parkinsons disease[J]. Am J Epidemiol, 2007, 166(5): 561-567.
[21] Ruggiero C, Cherubini A, Lauretani F, et al. Uric acid and dementia in community-dwelling older persons[J]. Dement Geriatr Cogn Disord, 2009, 27(4): 382-389.
[22] Keizman D, Ish-Shalom M, Berliner S, et al. Low uric acid levels in serum of patients with ALS: further evidence for oxidative stress?[J]. J Neurol Sci, 2009, 285(1-2): 95-99.
[1] LI Yinglin, SONG Daoqing, XU Zhonghua. Identification of FKBP11 expression in clear cell renal cell carcinoma using bioinformatics analysis [J]. Journal of Shandong University (Health Sciences), 2020, 1(9): 45-51.
[2] SHI Shuang, LI Juan, MI Qi, WANG Yunshan, DU Lutao, WANG Chuanxin. Construction and application of a miRNAs prognostic risk assessment model of gastric cancer [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 47-52.
[3] LI Xingkai, LIU Zhanye, JIANG Yunfeng, LI Jun. Clinicopathological factors and prognosis between primary central and peripheral lung squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(9): 73-78.
[4] ZONG Shuai, XIAO Dongjie, LIU Hua, JIA Yanfei, MA Xiaoli, LI Huanjie, LI Ping, ZHENG Yan, WANG Yunshan. Expression of CSN5 and its correlation with the prognosis of gastric carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(7): 12-16.
[5] SUN Qijing, CHEN Fangfang, LI Chunxiao, ZHANG Caiqing. Clinical value of PNI and HGB in evaluating the prognosis of the middle to late stage non-small cell lung cancer patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(4): 55-59.
[6] LIN Jiaxiang, GUO Zijia, SU Peng, WANG Xiao, GUO Yaxin, WU Xiaojuan, XIANG Lei, ZHOU Zhiqiang, WANG Yan, CUI Xiujie, PAN Aifeng, GUO Chenghao. The role of CIP2A in the transformation of breast ductal epithelium and prognosis of invasive breast cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(3): 100-106.
[7] ZHOU Lanlan, PAN Xueyi, GUO Yu. Clinical characteristics and prognosis of 48 patients with mixed phenotype acute leukemia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 79-83.
[8] ZHANG Xiying, ZHAI Chunyan, LI Jingsong, HAN Bo. Expression of EZH2 in Chinese Ewing sarcoma patients and its relationship with clinicopathological parameters and prognosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 84-91.
[9] LIU Huiling, WANG Xingwen, FENG Shaobin, FENG Hong, HAN Junqing. Association between high expression of scavenger receptor class B type I and the prognosis of colon cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 84-89.
[10] LI Xiaoning, CUI Lianqun. Treatment timing of non-infarct-related artery in patients with multi-vessel disease and acute myocardial infarction [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 50-54.
[11] WANG Wen, LIU Yao, LONG Fei, MA Weixia, SU Lili. Correlation between lymphocyte-to-monocyte ratio in peripheral blood and prognosis of malignant pleural mesothelioma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 72-77.
[12] LIU Tong, ZHANG Xin, WANG Chuanxin. Significance of IRX5 mRNA in the diagnosis and prognosis of colorectal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(7): 69-74.
[13] XU Zhihong, WU Xiaohua, YAO Tiezhu, WANG Xiaoxiang, DUAN Xiaoyang, SHI Jian. Relationship between mir-99a expression and prognosis of epithelial ovarian cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(3): 77-80.
[14] QU Lixin, SHI Xinghua, DU Yifeng. Relationship between circulating platelets microparticles and endothelial microparticls and prognosis in patients with acute ischemic stroke [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(12): 32-36.
[15] LIU Xiao, LIU Zhiguang, FAN Zhisong, WANG Yuan, YANG Xingxiao, KONG Jieyu, CHEN Junzhuo, LIU Junxia. Prognostic analysis of patients with severe sepsis and septic shock [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(10): 80-84.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd