JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (4): 46-50.doi: 10.6040/j.issn.1671-7554.0.2015.1158

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Prognostic hematological biomarkers of amyotrophic lateral sclerosis

MA Lin, ZHANG Dong, TANG Lei, YE Siyuan, YAN Chuanzhu, CAO Lili   

  1. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shangdong, China
  • Received:2015-11-24 Online:2016-04-10 Published:2016-04-10

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Abstract: Objective To investigate the relationship between some of hematological factors and the prognosis of amyotrophic lateral sclerosis(ALS), and search for hematology markers which could predict the prognosis of patients with ALS. Methods The retrospective study included 116 patients with ALS from the Qilu Hospital of Shandong University during January 2007 to December 2012. Their clinical data and routine hematological parameters were collected. Survival of patients was calculated by using the Kaplan-Meier method. The relationship between levels of hematological parameters and the survival curve of patients were analyzed by Log-rank test. Multivariate effect on survival time was analyzed with Cox proportional hazard model. Results The survival increased in patients with higher levels of serum albumin, creatinine(sCr), triglyceride(TG), lowdensity lipoprotein/ high density lipoprotein(LDL/HDL)or uric acid(UA). Moreover, a dose-response effect was found only in sCr and TG(P<0.05). Multivariable analysis showed that only sCr was an independent hematological marker affecting the prognosis of patients with ALS. Conclusion Blood lipid level and nutritional status are associated with survival of ALS patients, and sCr can be used as a potential independent prognostic biomarker of ALS.

Key words: Amyotrophic lateral sclerosis, Hematological parameter, Serum creatinine, Prognosis

CLC Number: 

  • R741
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