JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (3): 77-80.doi: 10.6040/j.issn.1671-7554.0.2015.929

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Relationship between mir-99a expression and prognosis of epithelial ovarian cancer

XU Zhihong1, WU Xiaohua2, YAO Tiezhu3, WANG Xiaoxiang1, DUAN Xiaoyang1, SHI Jian1   

  1. 1. Department of Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China;
    2. Department of Obstetrics and Gynaecology, Bethune International Peace Hospital, Shijiazhuang 050000, Hebei, China;
    3. Department of Cardiology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China
  • Received:2015-09-28 Online:2016-03-10 Published:2016-03-10

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Abstract: Objective To investigate the mir-99a expression in epithelial ovarian cancer(EOC), and its relationship with the clinicopathological features and prognosis. Methods The mir-99a expression in 137 cases of EOC tissues was detected with qRT-PCR assay. The correlation between mir-99a expression and clinicopathological features of EOC were analyzed. Survival curves for patients with different mir-99a expressions were plotted using the Kaplan-Meier method and compared using the log-rank test. Results The mir-99a expression reduced significantly in EOC tissues compared with that in adjacent normal tissues(P<0.001). Low mir-99a expression was significantly correlated with higher histological grade(P=0.027), lymph node metastasis(P=0.001), peritoneal metastasis(P<0.001), and higher FIGO stage(P<0.001). Kaplan-Meier analysis with log-rank test revealed that low mir-99a expression was correlated with short survival time of patients with EOC(log-rank test, P=0.005). Multivariate analysis showed that mir-99a expression was an independent prognostic factor for the overall survival(HR: 2.368, 95%CI: 1.621-10.925, P=0.016). Conclusion The mir-99a expression is an independent prognostic factor of patients with EOC. It can serve as a diagnostic and prognostic marker in clinical practice.

Key words: Epithelial ovarian cancer, Prognosis, mir-99a, Clinical pathology

CLC Number: 

  • R737.31
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