JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (7): 87-91.doi: 10.6040/j.issn.1671-7554.0.2015.138

Previous Articles     Next Articles

Clinico-pathological characteristics and diagnostic biomarkers in patients with esophageal carcinoma accompanied by neuroendocrine cell differentiation

LIU Lianke1, SHAO Mingwen2, MA Lan1, SUN Jing1, GUAN Dan1, SHU Yongqian1   

  1. 1. Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China;
    2. Department of Internal Medicine, Jiangsu Armed Police General Hospital, Yangzhou 225003, Jiangsu, China
  • Received:2015-02-03 Revised:2015-05-20 Published:2015-07-10

PDF (PC)

211

Abstract: Objective To investigate the clinico-pathological characteristics and diagnostic markers in esophageal carcinoma accompanied by neuroendocrine cell differentiation (E-NED). Methods The clinico-pathological data of 378 patients with poorly differentiated esophageal carcinoma from Jan. 2008 to Dec. 2013, including 349 without neuroendocrine differentiation (E-NNED) and 29 with neuroendocrine differentiation (E-NED), were retrospectively analyzed. The expressions of synaptophysin (SYN), chromogranin A (CgA), neuron-specific enolase (NSE), neural cell adhesion molecule (CD56), protein gene product (PGP9.5), secretagogin (SCGN) and thyroid transcription factor 1 (TTF-1) in the esophageal carcinoma tissues of 29 patients with E-NED and 20 ones randomly selected from the 349 patients with E-NNED were detected using immunohistochemistry. Results There were no significant differences between the patients with E-NED and E-NNED in terms of the age, gender, length of lesion and other clinico-pathological factors. Except for TTF-1, the expressions of Syn, CgA, NSE, CD56, PGP9.5 and SCGN were significantly higher in patients with E-NED than those with E-NNED (P<0.05). The sensitivity, positive predictive value anddiagnostic accuracy were all higher in the combined detection of Syn and CD56, PGP9.5 or SCGN than Syn and CgA (P<0.05). There were no significant differences between the patients with E-NED and E-NNED regarding 1, 2 and 3-year survival rates. Conclusion E-NED and E-NNED may be different pathological types of esophageal carcinoma. Both PGP9.5 and SCGN can be considered as the diagnostic markers of E-NED, and the combined detection of Syn and CD56, PGP9.5 or SCGN can improve the sensitivity and diagnostic accuracy.

Key words: Esophageal carcinoma, Neuroendocrine cell differentiation, Secretagogin, Prognosis, Synaptophysin, Neural cell adhesion molecule, Protein gene product 9.5

CLC Number: 

  • R735.1
[1] 汪慧访, 武爱文, 袁鹏, 等. 具有神经内分泌特征胃癌的诊治及预后分析[J]. 中华胃肠外科杂志, 2011, 14(2): 96-99. WANG Huifang, WU Aiwen, YUAN Peng, et al. Gastric neuroendocrine carcinoma and gastric carcinoma with neuroendocrine cell differentiation: a clinical and prognostic analysis[J]. Chin J Gastrointest Surg, 2011, 14(2): 96-99.
[2] Schartinger VH, Falkeis C, Laimer K, et al. Neuroendocrine differentiation in head and neck squamous cell carcinoma[J]. J Laryngol Otol, 2012, 126(12):1261-1270.
[3] 杜芸, 王永军, 杨会钗, 等. 食管早期鳞癌的神经内分泌分化及其意义[J]. 癌变·畸变·突变, 2006, 18(6): 459-461. DU Yun, WANG Yongjun, YANG Huichai, et al. Neuroendocrine differentiation and its significance in early esophageal squamous cell carcinoma[J]. Carcino Genesis, Terato Genesis & Mutagenesis, 2006, 18(6): 459-461.
[4] Yuan A , Liu J, Liu Y, et al. Chromogranin A-positive tumor cells in human esophageal squamous cell carcinomas[J]. Pathol Oncol Res, 2007, 13(4): 321-325.
[5] Bartley AN, Rashid A, Fournier KF, et al. Neuroendocrine and mucinous differentiation in signet ring cell carcinoma of the stomach: evidence for a common cell of origin in composite tumors[J]. Hum Pathol, 2011, 42(10): 1420-1429.
[6] Segawa Y, Takata S, Fujii M, et al. Immunohistochemical detection of neuroendocrine differentiation in non-small-cell lung cancer and its clinical implications[J]. J Cancer Res Clin Oncol, 2009, 135(8):1055-1059.
[7] 2013年中国胃肠胰神经内分泌肿瘤病理诊断共识专家组. 中国胃肠胰神经内分泌肿瘤病理诊断共识(2013版)[J]. 中华病理学杂志, 2013, 42(10): 691-694. 2013 Chinese Pathological Diagnostic Consensus Expert Group of Gastrointestinal and Pancreatic Neuroendocrine Tumor. Consensus of pathological diagnosis for Chinese gastrointestinal and pancreatic neuroendocrine[J]. Chinese J Pathol, 2013, 42(10): 691-694.
[8] 李景南, 张红杰, 陈洁, 等. 胃肠胰神经内分泌肿瘤内科诊治若干建议[J]. 中华消化杂志, 2014, 34(6): 361-367.
[9] 盛伟琪.胃肠胰神经内分泌肿瘤病理诊断的规范和进展[J]. 中国癌症杂志, 2013, 23(6) : 401-407. SHENG Weiqi. Advances and pathological diagnostic standard of gastroenteropancreatic neuroendocrine neoplasms[J]. China Oncology, 2013, 23(6):401-407.
[10] Stotz M, Eisner F, Szkandera J, et al. Clinico-pathological characteristics and clinical outcome of different histological types of pancreatic cancer in a large Middle European series[J]. J Clin Pathol, 2013, 66(9):753-757.
[11] 于红梅, 刘晓文, 龙子雯, 等. 胃癌伴神经内分泌分化的临床病理及预后分析[J]. 中国癌症杂志, 2013, 23(1): 42-46. YU Hongmei, LIU Xiaowen, LONG Ziwen, et al. Analysis of clinicopathological features and prognosis of gastric cancer with neuroendocrine cell differentiation[J]. China Oncology, 2013, 23(1): 42-46.
[12] Cho YB, Yang SS, Lee WY, et al. The clinical significance of neuroendocrine differentiation in T3-T4 node-negative colorectal cancer[J]. Int J Surg Pathol, 2010, 18(3): 201-206.
[13] 张军, 郑锴, 郭燕, 等. 非小细胞肺癌神经内分泌分化与其生物学特性及预后关系的研究[J]. 中国肺癌杂志, 2010, 13(9): 873-876. ZHANG Jun, ZHENG Kai, GUO Yan, et al. Research on the relationship between non-small cell lung cancer with neuroendocrine differentiation and the biological characteristics and prognosis[J]. Chin J Lung Cancer, 2010, 13(9): 873-876.
[14] Gottschling S, Jensen K, Herth FJ, et al. Lack of prognostic significance of neuroendocrine differentiation and stem cell antigen co-expression in resected early-stage non-small cell lung cancer[J]. Anticancer Res, 2013, 33(3): 981-990.
[15] Tian Z, Wei B, Tang F, et al. Prognostic significance of tumor grading and staging in mammary carcinomas with neuroendocrine differentiation[J]. Hum Pathol, 2011, 42(8): 1169-1177.
[16] Sawaki M, Yokoi K, Nagasaka T, et al. Prognostic importance of neuroendocrine differentiation in Japanese breast cancer patients[J]. Surg Today, 2010, 40(9): 831-835.
[1] LI Yinglin, SONG Daoqing, XU Zhonghua. Identification of FKBP11 expression in clear cell renal cell carcinoma using bioinformatics analysis [J]. Journal of Shandong University (Health Sciences), 2020, 1(9): 45-51.
[2] SHI Shuang, LI Juan, MI Qi, WANG Yunshan, DU Lutao, WANG Chuanxin. Construction and application of a miRNAs prognostic risk assessment model of gastric cancer [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 47-52.
[3] LI Xingkai, LIU Zhanye, JIANG Yunfeng, LI Jun. Clinicopathological factors and prognosis between primary central and peripheral lung squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(9): 73-78.
[4] ZONG Shuai, XIAO Dongjie, LIU Hua, JIA Yanfei, MA Xiaoli, LI Huanjie, LI Ping, ZHENG Yan, WANG Yunshan. Expression of CSN5 and its correlation with the prognosis of gastric carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(7): 12-16.
[5] SUN Qijing, CHEN Fangfang, LI Chunxiao, ZHANG Caiqing. Clinical value of PNI and HGB in evaluating the prognosis of the middle to late stage non-small cell lung cancer patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(4): 55-59.
[6] LIN Jiaxiang, GUO Zijia, SU Peng, WANG Xiao, GUO Yaxin, WU Xiaojuan, XIANG Lei, ZHOU Zhiqiang, WANG Yan, CUI Xiujie, PAN Aifeng, GUO Chenghao. The role of CIP2A in the transformation of breast ductal epithelium and prognosis of invasive breast cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(3): 100-106.
[7] ZHOU Lanlan, PAN Xueyi, GUO Yu. Clinical characteristics and prognosis of 48 patients with mixed phenotype acute leukemia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 79-83.
[8] ZHANG Xiying, ZHAI Chunyan, LI Jingsong, HAN Bo. Expression of EZH2 in Chinese Ewing sarcoma patients and its relationship with clinicopathological parameters and prognosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 84-91.
[9] LIU Huiling, WANG Xingwen, FENG Shaobin, FENG Hong, HAN Junqing. Association between high expression of scavenger receptor class B type I and the prognosis of colon cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 84-89.
[10] LI Xiaoning, CUI Lianqun. Treatment timing of non-infarct-related artery in patients with multi-vessel disease and acute myocardial infarction [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 50-54.
[11] WANG Wen, LIU Yao, LONG Fei, MA Weixia, SU Lili. Correlation between lymphocyte-to-monocyte ratio in peripheral blood and prognosis of malignant pleural mesothelioma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 72-77.
[12] LIU Tong, ZHANG Xin, WANG Chuanxin. Significance of IRX5 mRNA in the diagnosis and prognosis of colorectal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(7): 69-74.
[13] MA Lin, ZHANG Dong, TANG Lei, YE Siyuan, YAN Chuanzhu, CAO Lili. Prognostic hematological biomarkers of amyotrophic lateral sclerosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(4): 46-50.
[14] XU Zhihong, WU Xiaohua, YAO Tiezhu, WANG Xiaoxiang, DUAN Xiaoyang, SHI Jian. Relationship between mir-99a expression and prognosis of epithelial ovarian cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(3): 77-80.
[15] QU Lixin, SHI Xinghua, DU Yifeng. Relationship between circulating platelets microparticles and endothelial microparticls and prognosis in patients with acute ischemic stroke [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(12): 32-36.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd