JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (7): 82-86.doi: 10.6040/j.issn.1671-7554.0.2014.864

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Expressions of PDCD4 and survivin in condyloma acuminatum, Bowenoid papulosis, Bowen disease and squamous cell carcinoma

YU Shuping1, LI Xuefei1, WANG Dan1, WANG Yukun2   

  1. 1. Department of Dermatology, Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei, China;
    2. Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-11-24 Revised:2015-03-12 Published:2015-07-10

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Abstract: Objective To explore the expressions of programmed cell death 4 (PDCD4) and survivin in patients with condyloma acuminatum (CA), Bowenoid papulosis (BP), Bowen disease (BD) and squamous cell carcinoma (SCC). Methods The expressions of PDCD4 and survivin were detected in normal foreskin (n=10), CA (n=30), BP (n=28), BD (n=10) and SCC (n=11) with immunohistochemical techniques. Results The expression of PDCD4 in BP, BD and SCC was significantly lower than that in foreskin control (P<0.05), and it was lower in SCC than in CA (P<0.05). The expression of survivin in both BD and SCC was significantly higher than that in control (P<0.05), and it was higher in SCC than in CA (P<0.05). Conclusions PDCD4 can inhibit benign neoplasms from malignant transformation. The overexpression of survivin can inhibit cell apoptosis and promote proliferation.

Key words: Programmed cell death, Squamous cell carcinoma, Survivin, Conduloma acuminatum, Bowenoid papulosis, Bowen Disease

CLC Number: 

  • R739.5
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