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Expression  and significance of Survivin in human oral squamous cell carcinoma

WU Jinhua1, YANG Xihu1, LIU Zhenzhong2, DING Xiaojun1, XU Jianhui1   

  1. 1. Department of Stomatology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001,  Jiangsu, China;
    2. Department of Prosthodontics, Stomatological Hospital of Zhenjiang, Zhenjiang 212001, Jiangsu,  China
  • Received:2013-07-13 Online:2014-04-10 Published:2014-04-10

Abstract: Objective  To  investigate the expression of survivin in human oral squamous cell carcinoma and its clinical significance. Methods  The survivin expression in 46 cases of human oral squamous cell carcinoma was detected with SP immunohistochemical assay. Results  A total of 28 cases (60.8%) presented positive survivin expression, which was closely correlated with metastasis, clinical stages and prognosis. Conclusion  Survivin may play an important role in the tumorigenesis and development of human oral squamous cell carcinoma, serving as a valuable factor for its prognosis.

Key words: Survivin, Oral squamous cell carcinoma, Immunohistochemistry

CLC Number: 

  • R78
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