JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (9): 77-80.doi: 10.6040/j.issn.1671-7554.0.2014.400

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Research on the relationship between plasma D-dimer level and prognosis of breast cancer

LI Ling1, WANG Lili2, WANG Shengjiang2, YU Chao2, LIU Yanpeng2, XU Chengwei2   

  1. 1. Department of Surgery, Shandong Provincial Tumor Hospital, Jinan 250117, Shandong, China;
    2. Department of Laboratory Medicine, Second Hospital of Shandong University, Jinan 250033, Shandong, China
  • Received:2014-06-16 Revised:2014-09-04 Online:2014-09-10 Published:2014-09-10
  • Contact: 徐成伟。E-mail:xuchengwei-jyk@163.com E-mail:xuchengwei-jyk@163.com

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Abstract: Objective To analyze the changes of plasma D-dimer level in breast cancer patients, and to investigate the relationship between the level of D-dimer and prognosis of breast cancer. Methods A total of 92 cases of primary breast cancer and 85 healthy controls were enrolled. The level of D-dimer was measured with latex-enhanced immunoassay, and ER, PR, HER2, Ki-67 and P53 levels were detected with immunohistochemical methods. During the follow-up of 8 months, the plasma D-dimer levels in breast cancer patients were analyzed. Results The level of D-dimer in breast cancer patients was significantly higher compared to that of the healthy controls (P<0.01); the level of D-dimer in survivors during follow-up was significantly lower than that in those who died (P<0.05); the level of plasma D-dimer in breast cancer patients with different expressions of ER, PR, HER2, Ki-67 and P53 showed no significant difference (P>0.05). Conclusion D-dimer can act as a predictor of breast cancer prognosis, while it has nothing to do with other immunohistochemical indexes.

Key words: Breast cancer, D-dimer, Prognosis, Immunohistochemistry

CLC Number: 

  • R737.9
[1] Falanga A, Marchetti M, Vignoli A. Coagulation and cancer: biological and clinical aspects[J]. Journal of Thrombosis and Haemostasis, 2013, 11(2): 223-233.
[2] Zacharski L R, Ornstein D L. Venous thromboembolism and cancer[J]. N Eng J Med, 2000, 343(5): 1338-47.
[3] Dirix L Y, Salgado R, Weytjens R, et al. Plasma fibrin D-dimer levels correlate with tumour volume, progression rate and survival in patients with metastatic breast cancer[J]. Br J Cancer, 2002, 86(11): 389-395.
[4] Benoy I H, Salgado R, Elst H, et al. Relative microve-ssel area of the primary tumour, and not lymph node sta-tus, predicts the presence of bone marrow micrometasta-ses detected by reverse transcriptase polymerase chain re-action in patients with clinically non-metastatic breast cancer[J]. Breast Cancer Res, 2005, 7(2): 210-219.
[5] Kono T, Ohtsuki T, Hosomi N, et al. Clinical character-istics of ischemic stroke in elderly patients with cancer[J]. Nihon Ronen Igakai Zasshi, 2011, 48(1): 57-62.
[6] 王丽丽, 徐成伟. 恶性肿瘤血栓形成机制研究进展[J]. 血栓与止血学杂志, 2013, 19(5): 237-240. WANG Lili, XU Chengwei. Advances of Study on Thrombosis in Malignant Tumor[J]. Chinese Journal of Thrombosis and Haemostasis, 2013, 19 (5): 237-240.
[7] 王胜江, 徐成伟. 血浆中凝血酶激活的纤溶抑制物(TAFI)水平与慢性肝损伤相关性研究[J]. 山东大学学报: 医学版, 2012, 50(4): 83-86. WANG Shengjiang, XU Chengwei. Circulating levels of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) in patients with chronic liver disease[J]. Journal of Shan-dong University: Health Sciences, 2012, 50(4): 83-86.
[8] Batschauer A P, Figueiredo C P, Bueno E C, et al. D-di-mer as a possible prognostic marker of operable hormone receptor-negative breast cancer[J]. Ann Oncol, 2010, 21(6): 1267-1272.
[9] Ay C I, Dunkler D, Pirker R, et al. High D-dimer levels are associated with poor prognosis in cancer patients[J]. Haematologica, 2012, 97(8): 1158-1164.
[10] Carey L A, Dees E C, Sawyer L, et al. The triple nega-tive paradox: primary tumor chemosensitivity of breast cancer sub-types[J]. Clin Cancer Res, 2007,13 (8): 2329-2334.
[11] Dent R, Trudeau M, Pritchard K I, et al. Triple-nega-tive breast cancer: clinical features and patterns of recur-rence[J].Clin Cancer Res, 2007, 13(15): 4449-4434.
[12] Kausch I, Lingnau A, Endl E et al. Antisense treatment against Ki-67 mRNA inhibits proliferation and tumor growth in vitro and in vivo[J]. Int J Cancer, 2003, 105(12): 710-716.
[13] Rosa F E, Cladeira J R, Felipes J, et al. Evaluation of estrogen receptor alpha and beta and progesterone receptor expression and correlation with clinicopathologic fac-tors and proliferative marker Ki-67 in breast cancers[J]. Hum Pathol, 2008, 39(5): 720-730.
[14] Versteeg H H, Schaffner F, Kerver M, et al. Inhibition of tissue factor signaling suppresses tumor growth[J]. Blood, 2008, 111(1): 190-199.
[15] Warnberg F, Nordgren H, Bergkvist L, et al. Tumour markers in breast carcinoma correlate with grade rather than with invasiveness[J]. Br J Cancer, 2001, 85(6): 869-874.
[16] Choi H K, Roh S H, Kim H G, et al. Enhanced expression of aromatase in p53-inactivated mammary epithelial cells[J]. Endocr Relat Cancer, 2008, 15(1): 139-147.
[17] Dent R, Trudeau M, Pritchard K I, et al. Prognostic markers in Triple-negative breast cancer[J]. Cancer, 2007, 109(1): 25-32.
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