JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (7): 50-55.doi: 10.6040/j.issn.1671-7554.0.2016.058

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Quantitative analysis of spectral CT imaging on hypervascular hepatic metastasis and hepatocellular carcinoma

YUE Qianqian1, WANG Xinyi2, YANG Zhiqiang2, JIANG Shu2   

  1. 1. Taishan Medical University, Taian 271016, Shandong, China;
    2. Department of Radiology, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2016-01-14 Online:2016-07-10 Published:2016-07-10

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Abstract: Objective To evaluate the value of the spectral CT quantitative analysis in the differential diagnosis of hypervascular hepatic metastasis(HVHM)and hepatocellular carcinoma(HCC). Methods A total of 47 patients with hepatic malignant tumors undergoing spectral CT scan were divided into HVHM group(n=20)and HCC group(n=27). The monochromatic image sets, iodine-based material decomposition images and water-based material decomposition images were obtained, and the spectral parameters of lesions, normal hepatic tissues and aorta were measured. Then the normalized iodine concentrations(NIC), lesion-normal parenchyma iodine concentration ratio(LNR), iodine concentration difference(ICD)between the arterial phase and portal venous phase, and the slope of spectral curve were calculated. Independent samples t test and ROC were applied to analyze the quantitative parameters. Results Differences of the NIC, LNR and slope of spectral curve were not statistically significant(P>0.05)during arterial phase. Statistically significant differences of the NIC, LNR and slope of spectral curve were found between the HVHM 山 东 大 学 学 报 (医 学 版)54卷7期 -岳倩倩,等.富血供肝脏转移瘤与肝细胞肝癌的能谱CT成像定量分析 \=-group and the HCC group(P<0.05)during portal venous phase: NIC=0.59±0.08, 0.45±0.10; LNR=1.17±0.22, 0.92±0.16; the slopes of spectral curve=1.85±0.49, 1.18±0.34, respectively. Differences of ICD between the HVHM group and the HCC group were not statistically significant(P>0.05), and ICD were(0.54±0.39)g/L,(0.45±0.39)g/L, respectively. Differences of water(iodine)concentration in arterial and portal venous phase between the lesions were not statistically significant(P>0.05). The slope of spectral curve in the portal venous phase had the highest diagnostic efficiency in differentiating HVHM from HCC. Conclusions HVHM and HCC have different spectral characteristic parameters and spectral curves during portal venous phase. Spectral CT imaging provides a new multi-parameter quantitative analysis imaging method for differentiating HVHM and HCC.

Key words: Hepatic metastasis, Hypervascularity, Tomography, X-ray computed, Quantitative analysis, Spectral imaging, Hepatocellular carcinoma

CLC Number: 

  • R445
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