JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (7): 43-49.doi: 10.6040/j.issn.1671-7554.0.2015.1001

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Association between nonalcoholic fatty liver disease and chronic kidney disease: a retrospective cohort study

SHEN Zhenwei1, JI Xiaokang2, WANG Qinglian3, LI Jie1, XUE Fuzhong1, LIU Jing1   

  1. 1. Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Information and Data Analysis Lab, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    3. Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2015-10-21 Online:2016-07-10 Published:2016-07-10

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Abstract: Objective To explore the effect of nonalcoholic fatty liver disease(NAFLD)on the incidence of chronic kidney disease(CKD). Methods A retrospective cohort study was conducted using the data of regular physical examinations derived from the Health Management Center of Shandong Provincial Hospital. Participants who had physical examinations ≥3 times during 2005 and 2010 and whose renal function was normal at the first examination were included. Comparisons of the baseline characteristics between the participants with and without NAFLD were conducted with Student-t test or Pearson chi-square test. The cumulative incidences of CKD were estimated using Kaplan-Meier method for subjects with and without NAFLD at baseline respectively. Log-rank test was adopted to identify the difference between groups. Firstly, univariate Cox regression models were used to explore the association between the hazard of 山 东 大 学 学 报 (医 学 版)54卷7期 -申振伟,等.非酒精性脂肪肝与慢性肾脏病关系的回顾性队列研究 \=-CKD and the relevant factors such as demographic characteristics and biochemical measures. Further, multiple Cox regression model was used to estimate the effect of NAFLD on the incidence of CKD after adjusting these potential confounders. Results The cohort included 10 775 subjects and 34 878 person-years(average 3.24±0.99 years per person)were followed up. There were 1 068 CKD cases during the study period, and the incidence was 30.62/1 000 person-years. The cumulative CKD incidence of subjects with NAFLD at baseline was significantly higher than that of without NAFLD(22.76 vs 12.07, P<0.01). After adjusting the factors including age, gender, body mass index, systolic blood pressure, fasting blood-glucose, triglyceride, high density lipoprotein, hemoglobin, thrombocytocrit, hypertension, diabetes, metabolic syndrome and history of coronary heart disease, the HR of NAFLD to non-NAFLD on CKD was 1.20(95% CI: 1.05-1.38, P=0.01). Conclusion The existence of NAFLD was confirmed to be one independent risk factor for CKD in Chinese population. This finding will be helpful for prevention of CKD.

Key words: Chronic kidney disease, Cox regression, Cohort, Non-alcoholic fatty liver disease

CLC Number: 

  • R692
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