JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (9): 53-58.doi: 10.6040/j.issn.1671-7554.0.2016.249

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Relationship between uterine fibroid and hyperplasia of mammary glands: a cohort study

LI Xiangyi1, SUN Xiubin1, LU Yulian2, SHEN Zhenwei1, CHEN Yafei1, TANG Fang3, XUE Fuzhong1   

  1. 1. Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    3. Health Management Center, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2016-03-09 Online:2016-09-10 Published:2016-09-10

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Abstract: Objective To explore the association between uterine fibroid and hyperplasia of mammary glands based on a cohort design in Chinese population. Methods A longitudinal cohort based on large population was established to follow up the outcome of hyperplasia of mammary glands. Cox proportional hazards regression model and logistic model were used to detect the association between uterine fibroid and hyperplasia of mammary glands. Results The incidence density of hyperplasia of mammary glands was 205.23/1000 person-year. Unadjusted Cox model showed that relative risk(RR)value of uterine fibroids on hyperplasia of mammary glands was 1.26(95%CI: 1.12-1.43, P<0.001). Then, after adjusting age, the RR was changed to 1.37(95%CI: 1.21-1.55, P<0.001). After continually adjusting the factors of overweight, drinking, smoking, sleeping quality and other risk factors, the RR was 1.36 (95%CI: 1.19-1.55, P<0.001). Logistic model showed that HR of uterine fibroids on hyperplasia of mammary glands was 1.94(95%CI: 1.32-2.85, P<0.001). Conclusion The existence of uterine fibroids was still confirmed to be associated with hyperplasia of mammary glands after adjusting many known risk factors, suggesting that people suffering from uterine fibroids had a greater risk of hyperplasia of mammary glands.

Key words: Uterine fibroid, Association, Cox regression, Hyperplasia of mammary glands

CLC Number: 

  • R173
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