JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (9): 59-63.doi: 10.6040/j.issn.1671-7554.0.2016.357

Previous Articles     Next Articles

Expression and significance of human leucocyte antigen-E in cervical cancer

WANG Yao, CUI Guoying, WANG Fei, LI Changzhong   

  1. Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2016-03-31 Online:2016-09-10 Published:2016-09-10

PDF (PC)

242

Abstract: Objective To explore the correlation between expression of human leucocyte antigen-E(HLA-E)in cervical cancer and the pathological features of cervical cancer and its possible role in the pathogenesis of cervical cancer. Methods The expression of HLA-E was assayed by immunohistochemical staining in 18 cases of high-grade squamous intraepithelial lesion(HSIL), 74 cases of cervical cancer and 20 cases of adjacent normal tissues. The correlation between HLA-E expression and clinical staging, histological type, tumor differentiation, tumor size, lymph node metastasis, and muscle invasion was analyzed. Results Immunohistochemical staining showed the expression of HLA-E in cervical cancer and HSIL tissues were significantly higher than that in the adjacent normal cervical tissues(P=0.01), and the expression of HLA-E in cervical cancer was higher than that in the HSIL tissues(P<0.01). The expression of HLA-E was significantly correlated to tumor size and depth of myometrial invasion(all P<0.05), but not correlated to histological type, tumor differentiation, and lymph node metastasis(all P>0.05). Conclusion HLA-E expression is involved in the immune escape mechanism of cervical cancer. It may provide new directions and ideas for the treatment of cervical cancer by altering the immune status of patients.

Key words: Human Leucocyte Antigen-E, Cervical cancer, Immune escape, High-grade squamous intraepithelial lesion

CLC Number: 

  • R711.7
[1] 丰有吉, 沈铿, 马丁. 妇产科学[M]. 北京: 人民卫生出版社, 2015:296-301.
[2] Mehta AM, Jordanova ES, Kenter GG, et al. Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma[J]. Cancer Immunol Immunother, 2008, 57(2):197-206.
[3] Pyo CW, Williams LM, Moore Y, et al. HLA-E, HLA-F, and HLA-G polymorphism: genornic sequence defines haplotype structure and variation spanning the nonclassical class I genes[J]. Immunogenetics, 2006, 58(4): 241-251.
[4] Kraemer T, Blasczyk R, Bade-Doeding C. HLA-E: a novel player for histocompatibility[J]. J Immunol Res, 2014, 2014: 352160.doi: 10.1155/2014/352160. Epub 2014 Oct 20.
[5] Leos Krena, Pavel Fabian, Ondrej Slaby. Multifunctional immune-modulatory protein HLA-E identified in classical Hodgkin lymphoma: possible implications[J]. Pathol Res Pract, 2012, 208(1):45-49.
[6] Tremante E, Ginebri A, Lo Monaco E, et al. A melanoma immune response signature including Human Leukocyte Antigen-E[J]. Pigment Cell Melanoma Res, 2014, 27(1):103-112.
[7] Andersson E, Poschke I, Villabona L, et al. Non-classical HLA-class I expression in serous ovarian carcinoma: Correlation with the HLA-genotype, tumor infiltrating immune cells and prognosis[J]. Oncoimmunology, 2015, 5(1): e1052213. doi:10.1080/2162402X.2015.1052213.
[8] Kochan G, Escors D, Breckpot K, et al. Role of non-classical MHC class I molecules in cancer immunosuppression[J]. Oncoimmunology, 2013, 2(11):e26491. doi:10.4161/onci.26491.
[9] Sheu BC, Chiou SH, Lin HH, et al. Up-regulation of inhibitory natural killer receptors CD94/NKG2A with suppressed intracellular perforin expression of tumor-infiltrating CD8+ T lymphocytes in human cervical carcinoma[J]. Cancer Res, 2005, 65(7):2921-2929.
[10] Monnier-Benoit S, Mauny F, Riethmuller D, et al. Immunohistochemical analysis of CD4+ and CD8+ T- cell subsets in high risk human papillomavirus- associated pre- malignant and malignant lesions of the uterine cervix[J]. Gynecol Oncol, 2006, 102(1):22-31.
[11] Iwaszko M, Bogunia-Kubik K. Clinical significance of the HLA-E and CD94/NKG2 interaction[J]. Arch Immunol Ther Exp, 2011, 59(5):353-367.
[12] Wada H, Matsumoto N, Maenaka K, et al. The inhibitory NK cell receptor CD94/NKG2A and the activating receptor CD94/NKG2C bind the top of HLA-E through mostly shared but partly distinct sets of HLA-E residues[J]. Eur J Immunol, 2004, 34(1):81-90.
[13] Pietra G, Romagnani C, Manzini C, et al. The emerging role of HLA-E-restricted CD8+T lymphocytes in the adaptive immune response to pathogens and tumors[J]. J Biomed Biotechnol, 2010, 2010: 907092. doi:10.1155/2010/907092.
[14] Gonçalves AS, Oliveira JP, Oliveira CF, et al. Relevance of HLA-G, HLA-E and IL-10 expression in lip carcinogenesis[J]. Hum Immunol, 2016, 77(9):785-790.
[15] Guo ZY, Lv YG, Wang L, et al. Predictive value of HLA-G and HLA-E in the prognosis of colorectal cancer patients[J]. Cell Immunol, 2015, 293(1):10-16.
[16] Ishigami S, Arigami T, Okumura H, et al. Human Leukocyte Antigen(HLA)-E and HLA-F Expression in Gastric Cancer[J]. Anticancer Res, 2015, 35(4):2279-2285.
[17] Garcia-Iglesias T, Del Toro-Arreola A, Albarran-Somoza B, et al. Low NKp30, NKp46 and NKG2D expression and reduced cytotoxic activity on NK cells in cervical cancer and precursor lesions[J]. BMC Cancer, 2009, 9:186. doi:10.1186/1471-2407-9-186.
[18] Chen Z, Ding J, Pang N, et al. The Th17/Treg balance and the expression of related cytokines in Uygur cervical cancer patients[J]. Diagn Pathol, 2013, 8:61. doi:10.1186/1746-1596-8-61.
[19] Peghini BC, Abdalla DR, Barcelos ACM, et al. Local cytokine profiles of patients with cervical intraepithelial and invasive neoplasia[J]. Hum Immunol, 2012, 73(9):920-926.
[1] LIU Jingkang, YANG Jianyong, MENG Lihua, JIANG Jie. The value of serum miR-17-92 cluster in early diagnosis of HPV-positive cervical cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 86-90.
[2] SUN Zeyu, CHEN Ying, LIN Jiaxiang, LIU Juan, ZHAO Weiming. Influence of inositol polyphosphate-4-phosphatase type II on the proliferation and apoptosis of cervical cancer cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(11): 1-6.
[3] WANG Yafen, YANG Yongxia, LIU Ya, MA Demei, ZHU Lin. Use of Cervista HPV HR A9 group virus to identify patients with negative cytological but positive high-risk HPV [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 69-71.
[4] PENG Hui, HE Junmei, SU Xuelian. Expression of serum miR-375 and its clinical significance in the diagnosis and postoperative monitoring of cervical cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(3): 68-71.
[5] YUAN Shoudao, WANG Fengqin, ZHANG Jiao, ZHAO Weiming, Jason J. Chen. Mass spectrometry analysis of proteins differentially expressed between adenocarcinoma and squamous carcinoma of the cervix [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(8): 14-21.
[6] ZHANG Yanliang1, ZHUANG Zirong2, ZHU Lin1, LIANG Tingting1 . Quality of life after laparoscopic surgery for cervical cancer patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(6): 62-66.
[7] ZHANG Wen1, FENG Tingting1, ZHENG Lin1, WANG Hong1, LU Yi2, QI Mei1, YU Xiuping1, TANG Wei1, ZHAO Weiming1. Effects of enhanced expression of RbAp48 mediated by recombinant adenovirus on proliferation and growth of cervical cancer cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(4): 13-17.
[8] LIU Jian-meng， CUI Bao-xia， YIN Ting， ZHANG Ai-rong. Expression and significance of pigment epithelium-derived
factor in cervix squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(5): 103-106.
[9] ZHANG Xiao-Li, LI Xiao, WANG Xin, ZHENG Lin, DIAO Wei-Meng, JI Mei. null [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(12): 17-20.
[10] WU Han,HAN Zhen-long,CAO Ying-lin,GUO Chun,ZHU Fa-liang,CAO Li-li,ZHANG Li-ning,GAO Shang-xian,SHI Yong-yu. Expression of CD70 in hepatocellular carcinoma and its suppressive impact on the proliferation of lymphocytes [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(1): 27-30.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd