JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (9): 64-68.doi: 10.6040/j.issn.1671-7554.0.2016.248

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Correlation between multiorgan damage and perinatal asphyxia occurred at different gestational ages

QIU Jie1, ZANG Lijiao2, ZHUANG Genmiao2, AN Li2   

  1. 1. Graduate Department of Taishan Medical College, Taian 271016, Shandong, China;
    2. Department of Pediatrics, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China
  • Received:2016-03-08 Online:2016-09-10 Published:2016-09-10

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Abstract: Objective To study the relationship between multiorgan damage and perinatal asphyxia occurred at different gestational ages. Methods A total of 165 cases born in the Obstetrics Department of Jinan Central Hospital who had risks of neonatal asphyxia were collected. According to the results of umbilical arterial blood gas analysis and Apgar score, these neonates were divided into the premature asphyxia group, full-term asphyxia group, premature control group and full-term control group. The incidence of MODS was compared. The 79 cases of perinatal asphyxia were divided into early premature asphyxia group, late premature asphyxia group and full-term asphyxia group according to gestational ages. The severity of MODS was compared. Then the 79 cases of perinatal asphyxia were divided into mild asphyxia group and severe asphyxia group according to the degree of asphyxia, and the severity of MODS in the two groups was compared. Results The incidence of MODS was higher in the premature asphyxia group than in the full-term asphyxia group, with statistically significant difference(χ2=5.37, P<0.05). The severity of MODS following perinatal asphyxia was highest in the early premature asphyxia group, followed by late premature asphyxia group, and full-term asphyxia group, with statistically significant difference(χ2=6.11, P<0.05). There was correlation between the incidence of MODS and gestational age(r=0.29), and the degree of MODS and gestational age(r=0.35). There was statistical difference in the incidence of MODS, and severity of MODS between mild and severe asphyxia groups(χ2=9.30, P<0.05),(χ2=6.80, P<0.05). Conclusion Preterm infants have higher risk of MODS after 山 东 大 学 学 报 (医 学 版)54卷9期 -仇杰,等.不同胎龄围生期窒息与多器官功能损伤的相关性 \=-perinatal asphyxia than term infants. Smaller gestational age is correlated to higher incidence and severity of MODS. And the severity of perinatal asphyxia is positively correlated to the incidence and severity of MODS.

Key words: Neonatal asphyxia, Preterm infants, Full term infants, Multiple organ damage syndrome

CLC Number: 

  • R722
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