JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (9): 59-63.doi: 10.6040/j.issn.1671-7554.0.2016.357

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Expression and significance of human leucocyte antigen-E in cervical cancer

WANG Yao, CUI Guoying, WANG Fei, LI Changzhong   

  1. Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2016-03-31 Online:2016-09-10 Published:2016-09-10

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Abstract: Objective To explore the correlation between expression of human leucocyte antigen-E(HLA-E)in cervical cancer and the pathological features of cervical cancer and its possible role in the pathogenesis of cervical cancer. Methods The expression of HLA-E was assayed by immunohistochemical staining in 18 cases of high-grade squamous intraepithelial lesion(HSIL), 74 cases of cervical cancer and 20 cases of adjacent normal tissues. The correlation between HLA-E expression and clinical staging, histological type, tumor differentiation, tumor size, lymph node metastasis, and muscle invasion was analyzed. Results Immunohistochemical staining showed the expression of HLA-E in cervical cancer and HSIL tissues were significantly higher than that in the adjacent normal cervical tissues(P=0.01), and the expression of HLA-E in cervical cancer was higher than that in the HSIL tissues(P<0.01). The expression of HLA-E was significantly correlated to tumor size and depth of myometrial invasion(all P<0.05), but not correlated to histological type, tumor differentiation, and lymph node metastasis(all P>0.05). Conclusion HLA-E expression is involved in the immune escape mechanism of cervical cancer. It may provide new directions and ideas for the treatment of cervical cancer by altering the immune status of patients.

Key words: Human Leucocyte Antigen-E, Cervical cancer, Immune escape, High-grade squamous intraepithelial lesion

CLC Number: 

  • R711.7
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