JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (1): 86-91.doi: 10.6040/j.issn.1671-7554.0.2015.535

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Association between serum alanine transaminase with metabolic syndrome and its components based on a longitudinal health check-up study in Dongying City, China

XIAO Juan1*, CHEN Qicai2*, ZHANG Pengpeng3, CHEN Lili4, CHEN Xiaoxiao1, WANG Shumei1   

  1. 1. Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Health Examination Center, Central Hospital of Shengli Oilfield, Dongying 257000, Shandong, China;
    3. Department of Supervision, Tax-protected Zone Office, Tianjin Entry-Exit Inspection and Quarantine Bureau, Tianjin 300000, China;
    4. Department of Nutrition and Food Safety, Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China
  • Received:2015-05-30 Online:2016-01-11 Published:2016-01-11

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Abstract: Objective To investigate the association of serum alanine aminotransferase(ALT)with metabolic syndrome(MS, including hypertension, obesity, hyperlipidemia and hyperglycemia)categorized by different numbers of MS components at baseline. Methods A dynamic health examination cohort study was conducted during 2006 and 2011, which included 5 122 participants who satisfied two basic rules: being free of MS at 1st health check, and having at least three complete health checks. With generalized estimating equation(GEE)model, multivariable relative risk 山 东 大 学 学 报 (医 学 版)54卷1期 -肖娟,等.东营市某三甲医院纵向体检资料的血清谷丙转氨酶水平与代谢综合征的相关性 \=-(RRs)of time-varying ALT with MS and its components were analyzed. Results Increased serum ALT was positively associated with MS and its components. Compared with Q1, RRs(Q4 of ALT for MS)of participants with 0-2 components at baseline were 4.39(2.26-8.52), 6.97(3.37-14.42)and 1.93(1.26-2.95), respectively. Elevated ALT showed stronger predictability for MS in participants with 0 or 1 component of MS than participants with 2 components. Conclusion Elevated serum ALT is an early biomarker of MS and its components. Especially, it may increase the risk of MS in participants with 0 or 1 component of MS.

Key words: Alanine aminotransferase, Generalized estimating equation, Dynamic health examination cohort, Metabolic syndrome, Dongying City

CLC Number: 

  • R589.1
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