JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (5): 76-80.doi: 10.6040/j.issn.1671-7554.0.2017.191

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Correlation between hyperuricemi, Helicobacter pylori infection and metabolic syndrome

YU Zhenzhen1,2, CHEN Hui3, YANG Xiaoyun4, LÜ Ming1,3   

  1. 1. Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Health Examination Center;
    3. Department of Clinical Research;
    4. Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2017-03-05 Online:2017-05-10 Published:2017-05-10

Abstract: Objective To explore the correlation among serum uric acid(SUA), infection of helicobacter pylori (Hp)and metabolic syndrome(MS)in order to provide epidemiological evidences to reduce incidence of MS. Methods A cross-sectional study was conducted on 8 541 patients who met the inclusion standard, including 5 117 male and 3 424 female, aged 20~80(average 47.99±11.95)years. C-13 breath test-Hp and fasting blood biochemical examinations were conducted. The patients were divided into 2 groups, MS group(n=1 442)and non-MS(n=7 099), according 山 东 大 学 学 报 (医 学 版)55卷5期 -于珍珍,等.高尿酸血症、幽门螺杆菌感染与代谢综合征的相关性 \=-to the diagnostic criteria issued by Chinese Diabetes Society(CDS). According to age, the patients were divided into 3 groups: youth group(≤ 44 years), middle-aged group(45-59 years)and elderly group(≥ 60 years). According to the level of SUA, the patients were divided into SUA group and hyperuricemia(HUA)group. According to Hp status, the patients were divided into Hp+ and Hp- groups. According to the combination of SUA and HUA, the patients were divided into Hp- SUA, Hp+ SUA, Hp- HUA, and Hp+ HUA groups. The relationship between SUA, Hp infection and MS was analyzed with odds ratio and chi-square test. Results In the MS group, the male and female incidence rate was 22.1% and 9.0%, respectively, with statistical difference(P<0.05). The body mass index(BMI), systolic pressure(SBP), diastolic pressure(DBP), fasting blood glucose(FBG), triglyceride(TG)and Hp+ of MS group were higher than those of non-MS group(P<0.05), while high-density lipoprotein cholesterol(HDL-C)was lower than that of non-MS(P<0.001). Sex, age and Hp infection were related to HUA and MS, but not to MS(P<0.05). In both male and female groups, Hp infection was not related to MS; HUA and HUA complicated with Hp infection increased the incidence of MS(P<0.05). Hp infection increased the incidence of MS in the elderly group(P<0.05); HUA and HUA complicated with Hp infection increased the incidence of MS in all age groups(P<0.05). Conclusion Gender and age are closely related to MS; HUA and Hp infection are risk factors of MS.

Key words: Hyperuricemia, Helicobacter pylori, Metabolic syndrome, Infection, Physical examination

CLC Number: 

  • R181.3
[1] 中华医学会糖尿病学分会代谢综合征研究协作组. 中华医学会糖尿病学分会关于代谢综合征的建议[J]. 中华糖尿病杂志, 2004, 12(3): 156-161.
[2] Kassi E, Pervanidou P, Kaltsas G, et al. Metabolic syndrome: definitions and controversies[J]. BMC Med, 2011, 9(1): 48.
[3] Listed NUS. Department of health and human services: office of disease prevention and health promotion-healthy people 2010[J]. Nasnewsletter, 2000, 5(3): 3-3.
[4] Mottillo S, Filion KB, Genest J, et al. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis[J]. J Am Coll Cardiol, 2010, 56(14): 1113-1132.
[5] Florez H, Temprosa MG, Orchard TJ, et al. Metabolic syndrome components and their response to lifestyle and metformin interventions are associated with differences in diabetes risk in persons with impaired glucose tolerance[J]. Diabetes Obes Metab, 2014, 16(4): 326.
[6] Chen LW, Chien CY, Yang KJ, et al. Helicobacter Pylori infection increases insulin resistance and metabolic syndrome in residents younger than 50 years old: a community-based study[J]. PLoS One, 2015, 10(5): 128671. doi:10.1371/journal.pone.0128671.
[7] 胡颖, 时立新, 张巧, 等. 尿酸与代谢综合征及其组分的相关性分析[J]. 中华内分泌代谢杂志, 2014, 30(9): 765-768. HU Ying, SHI Lixin, ZHANG Qiao, et al. Association of serum uric acid with metabolic syndrome and its components[J]. Chinese Journal of Endocrinology and Metabolism, 2014, 30(9): 765-768.
[8] 林秀雯, 柯小瑚. 代谢综合征及其组分与尿酸的相关性分析[J]. 哈尔滨医药, 2016, 2(36): 138-139. LIN Xiuwen, KE Xiaohu. Correlation analysic of metabolic syndreme and its components with uric acid[J]. Harbin Medical Journal, 2016, 2(36): 138-139.
[9] 中华医学会内分泌学分会.高尿酸血症和痛风治疗的中国专家共识[J].中华内分泌代谢杂志, 2013, 29(11): 913-920.
[10] Xi B, He D, Hu Y, et al. Prevalence of metabolic syndrome and its influencing factors among the Chinese adults: the China Health and Nutrition Survey in 2009[J]. Prev Med, 2013, 57(6): 867-871.
[11] Liu L, Miura K, Fujiyoshi A, et al. Impact of metabolic syndrome on the risk of cardiovascular disease mortality in the United States and in Japan[J]. Am J Cardiol, 2014, 113(1): 84-89.
[12] 罗颖, 王丽丽, 龙娟, 等. 血浆尿酸浓度与冠状动脉粥样硬化性心脏病严重程度的相关性[J]. 岭南心血管病杂志, 2015, 21(4): 452-458. LUO Ying, WANG Lili, LONG Juan, et al. Relationship between serum concentration of uric acid and the severity of coronary artery disease[J]. South China Journal of Cardiovascular Diseases, 2015, 21(4): 452-458.
[13] 彭勃. 血尿酸水平与代谢综合征各组分及冠心病的相关分析[J]. 医学临床研究, 2013, 30(10): 2003-2005. PENG Bo. Analysis on the relationship of serum uric acid level with the components of metabolic syndrome and coronary heart disease[J]. Journal of Clinical Research, 2013, 30(10): 2003-2005.
[14] 张红梅. 血尿酸检测在心脑血管疾病诊断中的应用价值[J]. 中外医疗, 2013, 32(5): 182-183.
[15] Khedmat H, Amini M, Karbasi A, et al. The effect of Helicobacter pylori on vitamin B 12 blood levels in chronic renal failure patients: a single blind control trial[J]. Saudi J Kidney Dis Transpl, 2014, 25(4): 887.
[16] Khubchandani SR, Kulkarni S, Teckchandani S, et al. Ultrastructure of the H.pylori microbe in individuals having macrocytosis and B12 deficiency[J]. Ultrastruct Pathol, 2011, 35(5): 204-208.
[17] Chen Y, Blaser MJ. Association between gastric Helicobacter pylori colonization and glycated hemoglobin levels[J]. J Infect Dis, 2012, 205(8): 1195-1202.
[18] Polyzos SA, Kountouras J, Zavos C, et al. The association between Helicobacter Pylori infection and insulin resistance: a systematic review[J]. Helicobacter, 2011, 16(2): 79-88.
[19] Nam SY, Ryu KH, Park BJ, et al. Effects of Helicobacter pylori infection and its eradication on lipid profiles and cardiovascular diseases[J]. Helicobacter, 2014, 20(2): 125-132.
[20] Longo-Mbenza B, Nsenga JN, Mokondjimobe E, et al. Helicobacter Pylori infection is identified as a cardiovascular risk factor in Central Africans[J]. Vascular Health & Risk Management, 2012, 6(6): 455-461.
[21] Gen R, Demi RM, Ataseven H. Effect of Helicobacter pylori eradication on insulin resistance, serum lipids and low-grade inflammation[J]. South Med J, 2010, 103(3): 190-196.
[22] 赵红. 幽门螺杆菌感染与血糖代谢、血脂代谢指标的关系研究[J]. 中国医学创新, 2015, 12(20): 51-53. ZHAO Hong. Infection and the indexes of blood glucose metabolism and blood lipid metabolism[J]. Medical Innovation of China, 2015, 12(20): 51-53.
[23] Lee YH, Magkos F, Mantzoros CS, et al. Effects of leptin and adiponectin on pancreatic β-cell function[J]. Metabolism, 2011, 60(12): 1664-1672.
[24] Wang C, Guan Y, Yang J. Cytokines in the progression of pancreatic β-cell dysfunction[J]. Int J Endocrinol, 2010, 2010: 515136. doi: 10.1155/2010/515136.
[25] Matusiak A, Chaubiński M, Broncel M, et al. Putative consequences of exposure to Helicobacter pylori infection in patients with coronary heart disease in terms of humoral immune response and inflammation[J]. Arch Med Sci, 2016, 12(1): 45-54.
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