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Diagnostic value of aspartate beta-hydroxylase combined with AFP and GP73 for hepatocellular carcinoma

ZHANG Jizong1,2, MENG Jiuda2, DING Hai2, YI Yongxiang2, YU Zeqian3, ZHOU Jiahua3   

  1. 1. School of medicine, Southeast University, Nanjing 210009, Jiangsu, China;
    2. Department of Hepatobiliary Surgery, Second Hospital of Nanjing Affiliated to Southeast University,
    Nanjing 210003, Jiangsu, China;  3. Department of Hepatobiliary Surgery,  　Zhongda Hospital
    Affiliated to Southeast University, Nanjing 210009, Jiangsu, China
  • Received:2013-12-16 Online:2014-06-10 Published:2014-06-10

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Abstract: Objective  To investigate the diagnostic value of combined detection of serum aspartic acid asparaginebeta hydroxylase (Aspartate Beta-Hydroxylase ASPH), alpha fetoprotein (AFP) and Golgi glycoprotein 73 (GP73) in the diagnosis of primary hepatocellular carcinoma. Methods  The serum AFP, GP73 and ASPH were detected in 50 cases of primary liver cancer, 50 cases of liver cirrhosis and 50 healthy controls to analyze the significance of ASPH combined with AFP and GP73 in the diagnosis of primary hepatocellular carcinoma. Results  In liver cirrhosis group and healthy control group, AFP, GP73 and ASPH were significantly lower than in primary liver cancer group (P<0.05); the sensitivity of AFP, GP73 and ASPH detected alone in the diagnosis of primary hepatocellular carcinoma were 76.00%, 86.00% and 80.00%, respectively; the specificity were 88.00%, 98.00% and 86.00%, respectively; the accuracy was 82.00%, 92.00%, and 87.00% respectively. The sensitivity, specificity and accuracy of GP73 were the highest. Combined detection of AFP, GP73 and ASPH yielded the following Results  : sensitivity (96.00%), specificity (98.00%), accuracy (97.00%), which were higher than parame-ters obtained when AFP, GP73 and ASPH were detected alone. Conclusion  Combined detection of AFP, GP73 and ASPH can improve the diagnosis rate of primary hepatocellular carcinoma and early primary liver cancer.

Key words: Golgi glycoprotein 73, Aspartate beta-hydroxylase, Alpha fetoprotein, Hepatocellular carcinoma

CLC Number: 

  • R735.7
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