JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (10): 66-72.doi: 10.6040/j.issn.1671-7554.0.2015.299

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Meta-analysis of the prognosis of prenatally-diagnosed fetal agenesis of corpus callosum

WANG Yin1, MA Zhe2, TAO Guowei2, LIU Shaoping2, DING Tingting2, SHI Linlin2   

  1. 1. Department of Ultrasound, Xijing Hospital of Fourth Medical Military Medical University, Xi'an 710032, Shaanxi, China;
    2. Department of Ultrasound, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2015-03-20 Online:2015-10-10 Published:2015-10-10

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Abstract: Objective To explore the outcomes of agenesis of corpus callosum (ACC), and to compare the prognosis of isolated ACC with ACC complicated with other abnormalities. Methods Literature about the prognosis of ACC during 1990 to 2012 were retrieved and Meta-analysis was conducted. Results A total of 15 studies involving 565 cases were included. The overall rate of terminations was 65%. There was a higher incidence of ACC in males than in females, with the pooled RR=1.29, 95%CI=1.04-1.59, P<0.05. The overall rate of favorable prognosis for simple ACC was up to 70%, while that of ACC complicated with structural anomalies was 16%. There was statistical difference between the two values, the pooled OR=0.07, 95%CI=0.02-0.24, P<0.05. Conclusion There is a high rate of terminations due to prenatal diagnosis of fetal agenesis of corpus callosum. The incidence of ACC is higher in males than in females. The prognosis of isolated ACC is favorable, while the prognosis of ACC complicated with other anomalies is poor.

Key words: Prognosis, Agenesis of corpus callosum, Meta-analysis

CLC Number: 

  • R455.1
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