JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (5): 95-102.doi: 10.6040/j.issn.1671-7554.0.2016.1196

Previous Articles     Next Articles

Meta-analysis of the association between the STAT4 rs7574865 polymorphism and systemic lupus erythematosus

DU Jinge1, CHEN Hui2, YANG Xiaorong1, LÜ Ming1,2   

  1. 1. Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2016-09-23 Online:2017-05-10 Published:2017-05-10

PDF (PC)

155

Abstract: Objective To assess the association between STAT4 rs7574865 single nucleotide polymorphism and systemic lupus erythematosus by a Meta-analysis. Methods Two authors searched PubMed, Web of science, Scopus, China National Knowledge Infrastructure(CNKI)and Wanfang databases to identify relevant studies, independently. Odds ratio(OR)with 95% confidence interval(CI)were calculated to assess the strength of the association between rs7574865 polymorphism and SLE risk. Results A total of 27 studies were eventually included in this meta-analysis, which contained 21 902 SLE cases and 37 780 controls. Pooled analyses showed significant association between STAT4 rs7574865 polymorphism and SLE risk using allelic model(T vs G, OR=1.56, 95% CI: 1.49-1.63), homozygote model(TT vs GG, OR=2.32, 95% CI: 2.08-2.58), heterozygote model(TG vs GG, OR=1.52, 95% CI: 1.41-1.64), dominant model(TT/TG vs GG, OR=1.67, 95% CI: 1.55-1.79)and recessive model(TT vs TG/GG, OR=1.83, 95% CI: 1.65-2.02). In the subgroup analysis by region, evidences also showed significant association between rs7574865 polymorphism and SLE risk in all regions. Conclusion STAT4 rs7574865 G>T polymorphism correlate with an increased risk of SLE and the T allele may be a risk factor.

Key words: STAT4, Gene polymorphism, Single nucleotide polymorphism, Meta-analysis, Systemic lupus erythematosus

CLC Number: 

  • R181.3
[1] 冯金保. 中国汉族人群信号转导和转录激活因子-4基因单核苷酸多态性与系统性红斑狼疮的家系关联研究[D]. 合肥:安徽医科大学, 2010. FENG Jinbao. Family-based association study beween human STAT4 genes single nucleotide polymorphism with SLE in Chinese Han population[D]. Hefei: Anhui Medical University, 2010.
[2] Thakral A, Klein-Gitelman MS. An update on treatment and management of pediatric systemic lupus erythematosus[J]. Rheumatol Ther, 2016, 3(2): 209-219.
[3] Barton A, Thomson W, Ke X, et al. Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility[J]. Hum Mol Genet, 2008, 17(15): 2274-2279.
[4] Orozco G, Alizadeh BZ, Delgado-Vega AM, et al. Association of STAT4 with rheumatoid arthritis: a replication study in three European populations[J]. Arthritis Rheum, 2008, 58(7): 1974-1980.
[5] Zervou MI, Sidiropoulos P, Petraki E, et al. Association of a TRAF1 and a STAT4 gene polymorphism with increased risk for rheumatoid arthritis in a genetically homogeneous population[J]. Hum Immunol, 2008, 69(9): 567-571.
[6] Graham RR, Hom G, Ortmann W, et al. Review of recent genome-wide association scans in lupus[J]. J Intern Med, 2009, 265(6): 680-688.
[7] Mathur AN, Chang HC, Zisoulis DG, et al. Stat3 and Stat4 direct development of IL-17-secreting Th cells[J]. J Immunol, 2007, 178(8): 4901-4907.
[8] Wang Y, Miller S, Roulston D, et al. Genome-wide single-nucleotide polymorphism array analysis improves prognostication of acute lymphoblastic leukemia/lymphoma[J]. J Mol Diagn, 2016, 18(4): 595-603.
[9] Yousry SM, Shahin RM, EI Refai RM. Contribution of protein Z gene single-nucleotide polymorphism to systemic lupus erythematosus in Egyptian patients[J]. Blood Coagul Fibrinolysis, 2016, 27(6): 691-695.
[10] Watford WT, Hissong BD, Bream JH, et al. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4[J]. Immunol Rev, 2004, 202(1): 139-156.
[11] Leoncini E, Carioli G, La Vecchia C, et al. Risk factors for neuroendocrine neoplasms: a systematic review and meta-analysis[J]. Ann Oncol, 2016, 27(1): 68-81.
[12] Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses[J]. BMJ, 2003, 327(7414): 557-560.
[13] Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease[J]. J Natl Cancer Inst, 1959, 22(4): 719-748.
[14] Dersimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials: an update[J]. Contemp Clin Trials, 2007, 28(2): 105-114.
[15] Harbord RM, Egger M, Sterne JA. A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints[J]. Stat Med, 2006, 25(20): 3443-3457.
[16] Peters JL, Sutton AJ, Jones DR, et al. Performance of the trim and fill method in the presence of publication bias and between-study heterogeneity[J]. Stat Med, 2007, 26(25): 4544-4562.
[17] Raafat II, Azab NA, Khorshied MM, et al. Signal transducer and activator of transcription4(STAT4)G/T gene polymorphism in Egyptian systemic lupus erythematosus female patients[J]. The Egyptian Rheumatologist, 2015, 37(2): 75-80.
[18] Dang J, Shan S, Li J, et al. Gene-gene interactions of IRF5, STAT4, IKZF1 and ETS1 in systemic lupus erythematosus[J]. Tissue Antigens, 2014, 83(6): 401-408.
[19] Ciccacci C, Perricone C, Ceccarelli F, et al. A multilocus genetic study in a cohort of Italian SLE patients confirms the association with STAT4 gene and describes a new association with HCP5 gene[J]. PLoS One, 2014, 9(11): e111991. doi: 10.1371/journal.pone.0111991.
[20] Chai HC, Chua KH, Lim SK, et al. Insight into gene polymorphisms involved in toll-like receptor/interferon signalling pathways for systemic lupus erythematosus in South East Asia[J]. J Immunol Res, 2014, 529167. doi: 10.1155/2014/529167.
[21] Mirkazemi S, Akbarian M, Jamshidi AR, et al. Association of STAT4 rs7574865 with susceptibility to systemic lupus erythematosus in Iranian population[J]. Inflammation, 2013, 36(6): 1548-1552.
[22] Kadota K, Mori M, Yanagimachi M, et al. Analysis of gender differences in genetic risk: association of TNFAIP3 polymorphism with male childhood-onset systemic lupus erythematosus in the Japanese population[J]. PLoS One, 2013, 8(8): e72551. doi: 10.1371/journal.pone.0072551.
[23] Luan H, Li P, Cao C, et al. A single-nucleotide polymorphism of the STAT4 gene is associated with systemic lupus erythematosus(SLE)in female Chinese population[J]. Rheumatol Int, 2012, 32(5): 1251-1255.
[24] Sanchez E, Comeau ME, Freedman BI, et al. Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study[J]. Arthritis Rheum, 2011, 63(11): 3493-3501.
[25] Koga M, Kawasaki A, Ito I, et al. Cumulative association of eight susceptibility genes with systemic lupus erythematosus in a Japanese female population[J]. J Hum Genet, 2011, 56(7): 503-507.
[26] Chung SA, Taylor KE, Graham RR, et al. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production[J]. PLoS Genet, 2011, 7(3): e1001323. doi: 10.1371/journal.pgen.1001323.
[27] Yang W, Shen N, Ye DQ, et al. Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus[J]. PLoS Genet, 2010, 6(2):e1000841. doi: 10.1371/journal.pgen.1000841.
[28] Su Y, Zhao Y, Liu X, et al. Variation in STAT4 is associated with systemic lupus erythematosus in Chinese Northern Han population[J]. Chin Med J(Engl), 2010,123(22):3173-3177.
[29] Sanchez E, Webb RD, Rasmussen A, et al. Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus[J]. Arthritis Rheum, 2010, 62(12): 3722-3729.
[30] Yang W, Ng P, Zhao M, et al. Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese[J]. Genes Immun, 2009, 10(3): 219-226.
[31] Suarez-Gestal M, Calaza M, Endreffy E, et al. Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study[J]. Arthritis Res Ther, 2009, 11(3): R69. doi: 10.1186/ar2698.
[32] Kiyohara C, Washio M, Horiuchi T, et al. Cigarette smoking, STAT4 and TNFRSF1B polymorphisms, and systemic lupus erythematosus in a Japanese population[J]. J Rheumatol, 2009, 36(10): 2195-2203.
[33] Han JW, Zheng HF, Cui Y, et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus[J]. Nat Genet, 2009, 41(11): 1234-1237.
[34] Abelson AK, Delgado-Vega AM, Kozyrev SV, et al. STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk[J]. Ann Rheum Dis, 2009, 68(11): 1746-1753.
[35] Palomino-Morales RJ, Rojas-Villarraga A, Gonzalez CI, et al. STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians[J]. Genes Immun, 2008, 9(4): 379-382.
[36] Kobayashi S, Ikari K, Kaneko H, et al. Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population[J]. Arthritis Rheum, 2008, 58(7): 1940-1946.
[37] Taylor KE, Remmers EF, Lee AT, et al. Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus[J]. PLoS Genet, 2008, 4(5):e1000084. doi: 10.1371/journal.pgen.1000084.
[38] Kawasaki A, Ito I, Hikami K, et al. Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region[J]. Arthritis Res Ther, 2008, 10(5): R113. doi: 10.1186/ar2516.
[39] Harley JB, Alarcon-Riquelme ME, Criswell LA, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci[J]. Nat Genet, 2008, 40(2): 204-210.
[40] Remmers EF, Plenge RM, Lee AT, et al. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus[J]. N Engl J Med, 2007, 357(10): 977-986.
[41] 柏素云, 张立民, 王翠香, 等. STAT4基因单核苷酸多态性与系统性红斑狼疮关系的研究[J]. 免疫学杂志, 2010, 26(2): 183-185. BAI Suyun, ZHANG Limin, WANG Cuixiang, et al. The association between STAT4 rs7574865 single nucleotide polymorphism and SLE[J]. Immunological Journal, 2010, 26(2):183-185.
[42] 缪倩, 唐元家, 钱晓霞, 等. 中国汉族人群系统性红斑狼疮患者信号传导和转录激活子4基因多态性研究[J]. 中华风湿病学杂志, 2009, 13(8): 516-520. MIAO Qian, TANG Yuanjia, QIAN Xiaoxia, et al. STAT4 gene polymorphism in Chinese Han systemic lupus erythematosus[J]. Chin J Rheumatol, 2009, 13(8): 516-520.
[43] Beltran Ramirez O, Mendoza Rincon JF, Barbosa Cobos RE, et al. STAT4 confers risk for rheumatoid arthritis and systemic lupus erythematosus in Mexican patients[J]. Immunol Lett, 2016, 175: 40-43. doi: 10.1016/j.imlet.2016.05.003.
[44] 杨小蕾. STAT4基因多态性与云南汉族人群SLE发病的相关性研究[D]. 昆明:昆明医学院, 2011. YANG Xiaolei. Associated study between polymorphisms of STAT4 and systemic lupus erythematosus in the Han population of Yunan province[D]. Kunming: Kunming Medical University, 2011.
[45] 王丽. mtDNA单倍型M/N及核SNP STAT4rs3821236与湖南汉族女性SLE的相关性研究[D]. 长沙:中南大学, 2014. WANG Li. Association analysis of mtDNA haplogroup M/N and STAT4 rs3821236 to systemic lupus erythematosus risk in Han females from Hunan province[D]. Changsha: Central South University, 2014.
[46] Ji JD, Lee WJ, Kong KA, et al. Association of STAT4 polymorphism with rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis[J]. Mol Biol Rep, 2010, 37(1): 141-147.
[47] Liang YL, Wu H, Shen X, et al. Association of STAT4 rs7574865 polymorphism with autoimmune diseases: a meta-analysis[J]. Mol Biol Rep, 2012, 39(9): 8873-8882.
[1] MENG Zhaotun, LI Qin, SUN Hui, WU Xinfang, SUN Wenkai, GAO Wei. Correlation between interleukin-18 single nucleotide polymorphism and susceptibility of laryngeal squamous cell carcinoma: a report of 73 cases [J]. Journal of Shandong University (Health Sciences), 2020, 1(9): 58-63.
[2] LIN Pingzhen, XUE Jiaomei, YANG Bei, LI Meng, ZHOU Mailin, CAO Fenglin. Correlation between posttraumatic growth and psychological adjustment of cancer survivors based on Pearson correlation coefficient: a Meta-analysis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(9): 110-121.
[3] XU Daxia, HOU Nan, LI Xiaofeng, WANG Chuang, KONG Meng, JIAO Guangjun, CHEN Yunzhen. Relevance between bone metabolism of glucocorticoid-induced osteoporosis and duration of glucocorticoid treatment [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 103-107.
[4] MA Zhenzhen, SUN Hongsheng, YANG Qingrui. Changes and clinical significance of serum adipokines in systemic lupus erythematosus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(4): 86-90.
[5] WANG Lili, HUO Bin, WANG Lei, WANG Hao, HOU Dingkun, HUO Xiaodong, WANG Jinhuan, ZANG Li, CAO Qiang, CHAI Shude, WANG Haitao. Meta-analysis and system evaluation of 125I implantation in the treatment of early lung cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 76-83.
[6] XU Chuang, QI Dachun, LI Xianrang, ZU Meng, LI Jian, LIU Mingting. Do we really need wound drainage in hip arthroplasty? A meta-analysis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 43-49.
[7] Muhadasi TUERXUNYIMING, Patamu MOHEMAITI, Tuolanguli MAIMAITIKUERBAN. Association of CDKAL1 rs10946398 C/A polymorphism with type 2 diabetes [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(2): 75-85.
[8] SUN Xiangyao, HAI Yong, ZHANG Xinuo. Comparison of the adverse events of percutaneous pedicle screw fixation and traditional open pedicle screw fixation for thoracolumbar fractures: a Meta-analysis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(11): 56-63.
[9] SU Jing, XUE Jiaomei, SUN Feifei, GUO Zhaoxin, CHENG Xiangyu, MENG Liwei, LIU Zhaoxu. Comparison of nephron-sparing surgery and radical nephrectomy for T1b renal cell carcinoma: a Meta-analysis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(9): 65-70.
[10] LIU Jingsheng, LIU Guihua, DU Kun, ZHAO Qian, WENG Shaobo, ZHAO Xueying, ZHANG Xizhuang, JIN Xunbo. Serum TK1 for the diagnosis of cancer in Chinese patients: a Meta-analysis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(9): 71-79.
[11] LI Fang. Association between receptor of advanced glycation end products gene polymorphisms, soluble receptor of advanced glycation end products and susceptibility of type 2 diabetes mellitus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(12): 57-61.
[12] WANG Yin, MA Zhe, TAO Guowei, LIU Shaoping, DING Tingting, SHI Linlin. Meta-analysis of the prognosis of prenatally-diagnosed fetal agenesis of corpus callosum [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(10): 66-72.
[13] SUN Yuanyuan, GAO Wei, CUI Ying, ZHANG Hong, JIAO Jianfen, LI Kan, XU Ruicai. A systematic review on the effects of venous access port and PICC in cancer patients undergoing chemotherapy [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(10): 73-81.
[14] WANG Yao, CHEN Yan-hong, CHEN Hong. Correlation between sensibility, and side effects of 5-FU and DPYD gene polymorphisms in periphrel blood of patients with colon cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(S1): 18-21.
[15] YANG Yong-rong, LI Jun, LIANG Ye, LI Jin-du, LAN Jia-fu, LI Tian-zi. The study on association of TNF-α-238G/A gene polymorphisms in patients with oral lichen planus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(S1): 10-11.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd