JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (2): 75-85.doi: 10.6040/j.issn.1671-7554.0.2015.1143

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Association of CDKAL1 rs10946398 C/A polymorphism with type 2 diabetes

Muhadasi TUERXUNYIMING, Patamu MOHEMAITI, Tuolanguli MAIMAITIKUERBAN   

  1. School of Public Health, Xinjiang Medical University, Urumqi 830011, Xinjiang, China
  • Received:2015-11-20 Online:2016-02-10 Published:2016-02-10

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Abstract: Objective To investigate the relationship between cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1(CDKAL1)gene rs10946398 C/A single neucleotide polymorphism and the susceptibility of type 2 diabetes mellitus(T2DM). Methods Databases including PubMed, Web of Science, CNKI, Wanfang, and VIP were retrieved to search for literature on the association between T2DM and CDKAL1 gene rs10946398 C/A single neucleotide polymorphism. The odds ratio of CDKAL1 gene rs10946398 C/A genotype distributions in type 2 diabetic patients compared with healthy controls were analyzed. Rev-Man 5.3 software was applied for heterogeneity test and data merge. Altogether 16 case control studies were enrolled. Results In the whole population, a significant relationship between CDKAL1 rs10946398 C/A gene polymorphism and T2DM was observed under allelic(OR: 1.58, 95% CI: 1.30-1.93), recessive(OR: 1.14, 95% CI: 1.09-1.20), dominant(OR: 1.05, 95% CI: 1.01-1.09), and homozygous(OR: 1.19, 95% CI: 1.13-1.26), all P<0.01. Conclusion CDKAL1 rs10946398 C/A gene polymorphism is significantly associated with increased T2DM risk. The C allele of the CDKAL1 rs10946398 C/A gene polymorphism may confer susceptibility to T2DM.

Key words: Meta-analysis, Polymorphism, Type 2 diabetes mellitus, Susceptibility, CDKAL1

CLC Number: 

  • R587.1
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