JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (7): 33-37.doi: 10.6040/j.issn.1671-7554.0.2015.1355

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Association of serum testosterone level and non-alcoholic fatty liver disease in male patients with T2DM

LIN Dong1,2, GUAN Qingbo1,2   

  1. 1. Department of Endocrinology &
    Metabolism, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    2. Shandong Clinial Medical Center of Endocrinology and Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan 250021, Shandong, China
  • Received:2015-12-31 Online:2016-07-10 Published:2016-07-10

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Abstract: Objective To investigate the correlation between serum total testosterone(TT)and non-alcoholic fatty liver disease(NAFLD)in male patients with type 2 diabetes mellitus(T2DM). Methods A total of 199 male patients with T2DM were enrolled in the study. According to results of abdomen ultrasound, the subjects were divided into NAFLD group and non-NAFLD group. The NAFLD group was further divided into mild subgroup and moderate-severe subgroup according to the severity of NAFLD. The TT level was measured using electrochemiluminescent method. The other serological indicators were measured by Olympus automatic biochemistry analyzer. The correlation of TT and NAFLD was analyzed. Results The TT level of NAFLD group was lower than that of non-NAFLD group［3.29(2.54-4.21)vs 4.91(3.48-5.99), P<0.01］. The TT level of the moderate-severe subgroup was lower than that of the mild subgroup(3.06±1.11 vs 3.65±1.45, P=0.049). Conclusion Male T2DM patients with low TT level are at high risk of NAFLD. Low TT level is an independent risk factor for NAFLD in T2DM male patients.

Key words: Nonalcoholic fatty liver disease, Total serum testosterone, Insulin resistance, Type 2 diabetes mellitus

CLC Number: 

  • R588
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