JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (7): 33-37.doi: 10.6040/j.issn.1671-7554.0.2015.1355

Previous Articles     Next Articles

Association of serum testosterone level and non-alcoholic fatty liver disease in male patients with T2DM

LIN Dong1,2, GUAN Qingbo1,2   

  1. 1. Department of Endocrinology &
    Metabolism, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    2. Shandong Clinial Medical Center of Endocrinology and Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan 250021, Shandong, China
  • Received:2015-12-31 Online:2016-07-10 Published:2016-07-10

PDF (PC)

287

Abstract: Objective To investigate the correlation between serum total testosterone(TT)and non-alcoholic fatty liver disease(NAFLD)in male patients with type 2 diabetes mellitus(T2DM). Methods A total of 199 male patients with T2DM were enrolled in the study. According to results of abdomen ultrasound, the subjects were divided into NAFLD group and non-NAFLD group. The NAFLD group was further divided into mild subgroup and moderate-severe subgroup according to the severity of NAFLD. The TT level was measured using electrochemiluminescent method. The other serological indicators were measured by Olympus automatic biochemistry analyzer. The correlation of TT and NAFLD was analyzed. Results The TT level of NAFLD group was lower than that of non-NAFLD group［3.29(2.54-4.21)vs 4.91(3.48-5.99), P<0.01］. The TT level of the moderate-severe subgroup was lower than that of the mild subgroup(3.06±1.11 vs 3.65±1.45, P=0.049). Conclusion Male T2DM patients with low TT level are at high risk of NAFLD. Low TT level is an independent risk factor for NAFLD in T2DM male patients.

Key words: Nonalcoholic fatty liver disease, Total serum testosterone, Insulin resistance, Type 2 diabetes mellitus

CLC Number: 

  • R588
[1] Suzuki A, Angulo P, Lymp J, et al. Chronological development of elevated aminotransferases in a nonalcoholic population[J]. Hepatology, 2005, 41(1): 64-71.
[2] Medina J, Fernandez-Salazar LI, Garcia-Buey L, et al. Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis[J]. Diabetes Care, 2004, 27(8): 2057-2066.
[3] Choi SY, Kim HJ, Kang JH, et al. The relation between non-alcoholic fatty liver disease and the risk of coronary heart disease in Koreans[J]. Am J Gastroenterol, 2009, 104(8): 1953-1960.
[4] Rohrmann S, Shiels MS, Lopez DS, et al. Body fatness and sex steroid hormone concentration in US men: result from NHANES III[J]. Cancer Causes & Control, 2011, 22(8): 1141-1151.
[5] Kim S, Kwon H, Park JH, et al. A low level of serum total testosterone is independently associated with non-alcoholic fatty liver disease[J]. BMC Gastroenterol, 2012, 12: 69[M8]. doi: 10.1186/1471-230X-12-69.
[6] Tian GX, Sun Y, Pang CJ, et al. Oestradiol is a protective factor for non-alcoholic fatty liver disease in health man[J]. Obes Rev, 2012, 13(4): 381-387.
[7] Farsell GC, Chitturi S, Lau GK, et al. Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary[J]. J Gastroenterol Hepatol, 2007, 22(6): 775-777.
[8] Fan JG, Falrell GC. Epidemiology of non-alcoholic fatty liver disease in China[J]. J Hepatol, 2009, 50(1): 204-210.
[9] Kim D, Choi SY, Park EH, et al. Nonalcoholic fatty liver disease is associated with coronary artery calcification[J]. Hepatology, 2012, 56(2): 605-613.
[10] Kalra S, Vithalani M, Gulati G, et al. Study of prevalence of nonalcoholic fatty liver disease(NAFLD)in type 2 diabetes patients in india(SPRINT)[J]. J Assoc Physicians India, 2013, 61(7): 448-453.
[11] Prashanth M, Ganesh HK, Vima MV, et al. Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus[J]. J Assoc Physicians India, 2009, 57: 205-210.
[12] Tolman KG, Fonseca V, Dalpiaz A, et al. Spectrum of liver disease in type 2 diabetes and management of patients with diabetes and liver disease[R]. Diabetes Care, 2007, 30(3): 734-743.
[13] Farrell GC, Chitturi S, Lau GK, et al. Asia-Pacific Working Party on NAFLD. Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary[J]. J Gastroenterol Hepatol, 2007, 22(6): 775-777.
[14] Yialamas MA, Dwyer AA, Hanley E, et al. Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism[J]. J Clin Endocrinol Metab, 2007, 92(11): 4254-4259.
[15] Grossmann M, Thomas MC, Panagiotopoulos S, et al. Low testosterone levels are common and associated with insulin resistance in men with diabetes[J]. J Clin Endocrinol Metab, 2008, 93(5): 1834-1840.
[16] Saad F, Gooren L. The role of testosterone in the metabolic syndrome: a review[J]. J Steroid Biochem Mol Biol, 2009, 114(1-2): 40-43.
[17] Holmlng A, Bjdrntorp P. The effects of cortisol on insulin sensitivity in muscle[J]. Acta Physiol Stand, 1992, 144(4): 425-431.
[18] 李霞, 周智广, 亓海英, 等. 用空腹C肽代替胰岛素改良Homa公式评价胰岛素抵抗和胰岛β细胞功能[J]. 中南大学学报(医学版), 2004, 29(4): 419-423. LI Xia, ZHOU Zhiguang, QI Haiying, et al. Replacement of insulin by fasting C-peptide in modified homeostasis model assessment to evaluate insulin resistance and islet cell function[J]. J Cent South Univ(Med sci), 2004, 29(4): 419-423.
[19] Alkhouri N, Eng K, Lopez R, et al. Non-high-density lipoprotein cholesterol(non-HDL-C)levels in children with nonalcoholic fatty liver disease(NAFLD)[J]. Springerplus, 2014, 3: 407.
[20] Cao W, Zhao C, Shen C, et al. Cytokeratin 18, alanine aminotransferase, platelets and triglycerides predict the presence of nonalcoholic steatohepatitis[J]. PLoS One, 2013, 8(12): 82092.
[21] Hamilton EJ, Gianatti E, Strauss BJ, et al. Increase in visceral and subcutaneous abdominal fat in men with prostate cancer treated with androgen deprivation therapy[J]. Clin Endocrinol(Oxf), 2011, 74(3): 377-383.
[22] Schroeder ET, Zheng L, Ong MD, et al. Effects of androgen therapy on adipose tissue and metabolism in older men[J]. J Clin Endocrinol Metab, 2004, 89(10): 4863-4872.
[23] Miller KK. Androgen deficiency: effects on body composition[J]. Pituitary, 2009, 12(2): 116-124.
[24] Fried1 KE, Hannan CJ Jr, Jones RE, et al. High density lipoprotein cholesterol is not decreased if an aromabzable androgen is administered[J]. Metabolism, 1990, 39(1): 69-74.
[25] Xu X, De Pergola G, Bjdrntorp P. The effects of androgens on the regulation of lipolysis in adipose precursor cells[J]. Endocrinology, 1990, 126(2): 1229-1234.
[26] Krotkiewski M, Björntorp P, Sjöström L, et al. Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution[J]. J Clin Invest, 1983, 72(3): 1150-1162.
[1] ZHANG Yuan, LI Yang-Min, FENG Rue-Qiu, CHANG Cai-Yun, PAN Hua-Wei, WANG Shu-Mei. Relationship among serum adiponectin level, obesity and insulin resistance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 124-.
[2] JIANG Zheng, SHEN Zhenwei, ZHANG Guang, LI Runzi, CAO Jin, WANG Li, XUE Fuzhong, LIU Yanxun. Construction of a NAFLD screening tool based on health examination subjects [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(6): 114-118.
[3] LIU Xiaojuan, JIANG Zheng, KANG Fengling, ZHOU Miao, LIN Weiqiang, XUE Fuzhong. Association between neutrophil count and nonalcoholic fatty liver disease:a prospective cohort study [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(6): 119-123.
[4] LI Shuai, WANG Yalin, SUN Zhongwen, ZHU Meijia. Expression changes and mechanism of Nod-like receptor protein 3 inflammasome in the cerebral microvascular endothelial cells in type 2 diabetes mellitus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(3): 6-11.
[5] LI Jian, XU Bing, YAN Xinfeng, XU Wanju, CHANG Xiaotian. Screening key genes for TXNDC5 and insulin signaling pathway [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(3): 88-93.
[6] LI Hongzhi, SHEN Yongchao, LIU Jieting, ZHAO Xiaojin, CHU Yanhui, YUAN Xiaohuan. An 11β-HSD1 inhibitor improves insulin sensitivity in db/db mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 59-64.
[7] JIA Yueyue, LIU Hongbin, LI Jingbo, LI Jing, ZHANG Jiangtao, SUN Mei, SHI Yuhua. Expression of microRNA-200b in granulosa cells of PCOS patients and its significance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 63-68.
[8] LI Jingbo, LIU Hongbin, JIA Yueyue, WANG Ze, SUN Mei, SHI Yuhua. Expression and clinical significance of microRNA-183 in polycystic ovary syndrome with insulin resistance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 69-74.
[9] PENG Li, QIANG Ye, ZHAO Huichen, CHEN Shihong, YAO Weidong, LIU Yuantao. Clinical studies on type 2 diabetic patients treated with sitagliptin [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 60-63.
[10] Muhadasi TUERXUNYIMING, Patamu MOHEMAITI, Tuolanguli MAIMAITIKUERBAN. Association of CDKAL1 rs10946398 C/A polymorphism with type 2 diabetes [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(2): 75-85.
[11] XU Yibo, JI Xiaokang, LI Xiangyi, SHEN Zhenwei, XUE Fuzhong. Analysis on the relationship between urine pH and metabolic syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(12): 82-85.
[12] YU Ning, GAO Yanyan, XIAN Yuxin, NIU Jiapeng, LI Li, WANG Jing, CAO Caixia. Effect of exenatide on serum chemerin level and liver fat contents in type 2 diabetes mellitus combined with non-alcoholic fatty liver disease patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(11): 51-55.
[13] LIU Yanxun, LIU Jia, ZHANG Tao, WANG Lu, XUE Fuzhong, WANG Ping. Type 2 diabetes mellitus associated with thyroid nodules: a longitudinal health check-up cohort study [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(8): 83-86.
[14] PEI Leilei, SUN Zhonghua, LI Zhe, ZHAO Wenping. Effects of sitagliptin combined with high-dose insulin on type 2 diabetes mellitus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(2): 39-42.
[15] HU Fangzhi, ZHANG Zhengjun, GENG Houfa, LIANG Qiuhua, SUN Lin. Relationship between microalbuminuria and brain damage in patients with type 2 diabetes mellitus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(2): 43-47.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd