JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (8): 60-63.doi: 10.6040/j.issn.1671-7554.0.2016.199

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Clinical studies on type 2 diabetic patients treated with sitagliptin

PENG Li1, QIANG Ye2, ZHAO Huichen2, CHEN Shihong3, YAO Weidong1, LIU Yuantao2   

  1. 1. Cadres Ward, Jinan Fourth Peoples Hospital, Jinan 250031, Shandong, China;
    2. Department of Endocrinology, Qingdao Municipal Hospital, Qingdao 266011, Shandong, China;
    3. Department of Endocrinology, Second Hospital of Shandong University, Jinan 250033, Shandong, China
  • Received:2016-02-29 Online:2016-08-10 Published:2016-08-10

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Abstract: Objective To analyze the factors that affect the efficacy of sitagliptin in the treatment of type 2 diabetic mellitus(T2DM)patients. Methods Clinical data of 86 T2DM patients who treated with sitagliptin during Sept.2012 and June 2014 were collected. According to the levels of fasting C peptide, the patients were divided into two groups: maximum C peptide group(n=12)and minimum C peptide group(n=12). Multiple line regression analysis was performed to analyze the factors that might affect the efficacy of sitagliptin. Results After administration of sitagliptin, there was no significant difference in the decrease of fasting blood glucose(FBG)and 2 h post prandial blood glucose(2h-PBG)between the maximum and minimum C peptide groups(P>0.05). Multiple line regression analysis showed that HbA1c was an independent factor that affected the decrease of FBG; baseline 2h-PBG level was an independent factor that affected the efficacy of sitagliptin on 2h-PBG. Sitagliptin significantly decreased glucose excursion(P<0.05), and reduced episodes of hypoglycemia. Conclusion Sitagliptin decreases both FBG and 2h-PBG. The efficacy of sitagliptin may not entirely depend on C peptide levels. Sitagliptin significantly decreases blood excursion and hypoglycemia.

Key words: Type 2 diabetes mellitus, Sitagliptin, Fasting blood glucose, 2 h post prandial blood glucose

CLC Number: 

  • R574
[1] Nauck M, Stöckmann F, Ebert R, et al. Reduced incretin effect in type 2(non-insulin-dependent)diabetes[J]. Diabetologia, 1986, 29(1): 46-52.
[2] Abraham EJ, Leech CA, Lin JC, et al. Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells[J]. Endocrinology, 2002, 143(8): 3152-3161.
[3] Mannucci E, Pala L, Ciani S, et al. Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus[J]. Diabetologia, 2005, 48(6): 1168-1172.
[4] 叶潇, 张倩, 曹瑛, 等. 西格列汀与阿卡波糖治疗新诊断2型糖尿病患者的疗效比较[J]. 中国糖尿病杂志, 2012, 8(20): 619-621. YE Xiao, ZHANG Qian, CAO Ying, et al. Comparison of therapeutic effects of sitagliptin versus acarbose for newly-diagnosed T2DM patients[J]. Chin J Diabetes, 2012, 8(20): 619-621.
[5] Giuseppe D, Pietro DR, Elena F, et al. Sitagliptin added to previously taken antidiabetic agents on insulin resistance and lipid profile: a 2-year study evaluation[J]. Fund Clin Pharmacol, 2014, 28(2): 221-229
[6] Keiji Y. Efficacy of initial basal-supported oral therapy with sitagliptin in untreated type 2 diabetes[J]. Diabetes Ther, 2013, 4(2): 409-416.
[7] Mu J, Woods J, Zhou YP, et al. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes[J]. Diabetes, 2006, 55(6): 1695-1704.
[8] Pospisilik JA, Martin J, Doty T, et al. Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats[J]. Diabetes, 2003, 52(3): 741-750.
[9] Yuan GY, Jia J, Zhang CL, et al. Safety and effcacy of sitagliptin in combination with transient continuous subcutaneous insulin infusion(CSII)therapy in patients with newly diagnosed type 2 diabetes[J]. Endocrine Journal, 2014, 61(5): 513-521.
[10] Lu J, Zang J, Li H. Impact of three oral antidiabetic drugs on markers of b-Cell function in patients with type 2 diabetes: A meta-analysis[J]. PLoS One, 8(10): e76713. doi:10.1371/journal.pone.0076713.
[11] Gerald HT. Treatment of type 2 diabetes, lifestyle, GLP1 agonists and DPP4 inhibitors[J]. World J Diabetes, 2014, 5(5): 636-650.
[12] Holst JJ. The physiology of glucagon-like peptide 1[J]. Physiol Rev, 2007, 87(4): 1409-1439.
[13] Urd K, Jens JH, Sten M. Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual b-Cell function[J]. Diabetes, 2011, 60(5): 1599-1607.
[14] Behme MT, Dupré J, McDonald TJ. Glucagon-like peptide 1 improved glycemic control in type 1 diabetes[J]. BMC Endocr Disord, 2003, 3(1): 3.
[15] Creutzfeldt WO, Kleine N, Willms B, et al. Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36)amide in type I diabetic patients[J]. Diabetes Care, 1996, 19(6): 580-586.
[16] Aschner P, Kipnes MS, Lunceford JK, et al. Effect of the dipeptidyl peptidase-4 inhibitorsitagliptinas monotherapy on glycemic control in patients with type 2 diabetes[J]. Diabetes Care, 2006, 29(12): 2632-2637.
[17] Nauck MA, Heimesaat MM, Behle K, et al. Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers[J]. J Clin Endocrinol Metab, 2002, 87(3): 1239-1246.
[18] PKC-DRS Study Group. The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe non-proliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study(PKC-DRS)multicenter randomized clinical trial[J]. Diabetes, 2005, 54(7): 2188-2197.
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