JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (8): 55-59.doi: 10.6040/j.issn.1671-7554.0.2015.1345

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Effects of perindopril on the expression of plasma miR-423-5p and cardiac function in patients with heart failure

JIANG Yunshan1, TAN Hong2, LI Xiaoyan2, SU Li3, ZHANG Guoming2, ZHANG Hongming2, MENG Nan1   

  1. 1. Base of Postgraduate Education, General Hospital of Jinan Military Command, Jinzhou Medical University, Jinan 250031, Shandong, China;
    2. Department of Cardiology, General Hospital of Jinan Military Command, Jinan 250031, Shandong, China;
    3. Second Department of Cadre, General Hospital of Jinan Military Command, Jinan 250031, Shandong, China
  • Received:2015-12-28 Online:2016-08-10 Published:2016-08-10

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Abstract: Objective To explore the effects of perindopril with different doses on the expression of plasma miR-423-5p in patients with chronic heart failure(CHF)and its correlation with the cardiac function. Methods A total of 75 CHF patients were randomly divided into 3 groups: routine group(n=25, treated with routine medicine), low-dose group(n=25, treated with 4 mg/d perindopril), and high-dose group(n=25, treated with 8 mg/d perindopril). Another 25 healthy controls were enrolled in the control group. After 4 weeks of treatment, pre- and post-treatment levels of LVEDD, LVEF, NT-proBNP, and miR-432-5p of all subjects were measured. Results The baseline level of LVEF of the routine, low-dose and high-dose groups were remarkably lower than that of the control group(P<0.05), while the 山 东 大 学 学 报 (医 学 版)54卷8期 -姜蕴珊,等.培哚普利对慢性心力衰竭患者血浆miR-423-5p的调控及对心功能的影响 \=-baseline levels of LVEDD, NT-proBNP and miR-423-5p of the routine, low-dose and high-dose groups were significantly higher than those of the control group(P<0.05). After 4 weeks of treatment, the level of LVEF of the routine, low-dose and high-dose groups remarkably increased(P<0.05), while the levels of LVEDD, NT-proBNP and miR-423-5p remarkably decreased(P<0.05). After treatment, the LVEF of the low-dose and high-dose groups was significantly higher than that of the routine group(P<0.05), while the LVEDD, NT-proBNP and miR-423-5p levels were significantly lower than those of the routine group(P<0.05). Compared with the low-dose group, the high-dose group had more significant different levels of LVEF, LVEDD, NT-proBNP, and miR-423-5p(P<0.05). Conclusion Perindopril can reduce the plasma miR-423-5p expression in CHF patients, and improve the cardiac function in a dose dependent manner.

Key words: Left ventricular ejection fraction, Heart failure, MicroRNA-423-5p, Perindopril, N-terminal pro-brain natriuretic peptide

CLC Number: 

  • R541.4
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