JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (12): 57-61.doi: 10.6040/j.issn.1671-7554.0.2015.901

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Association between receptor of advanced glycation end products gene polymorphisms, soluble receptor of advanced glycation end products and susceptibility of type 2 diabetes mellitus

LI Fang   

  1. Department of Preventive Medicine, Jinan Central Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2015-09-23 Online:2015-12-10 Published:2015-12-10

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Abstract: Objective To estimate the level of soluble receptor of advanced glycation end product (sRAGE) in type 2 diabetes mellitus, as well as its association with single nucleotide polymorphism (SNP) of receptor of advanced glycation end product (RAGE). Methods A total of 184 patients with type 2 diabetes mellitus and 190 healthy controls were recruited. ELISA was applied to test sRAGE, and PCR-TaqMan-MGB probe was used for the genotyping of rs2070600, rs1800624, rs1800625 and rs184003. Results The level of sRAGE[M(P25,P75)] in type 2 diabetes mellitus patients was[1087.4(713.5,1213.4) pg/mL], which was significantly higher than that of the controls[908.2(674.6,1107.1 pg/mL)]. As to the allele analysis, no significant differences were observed in the minor allele frequency comparisons of the 4 SNPs, and no association was found between the 4 SNPs and sRAGE level in the linear regression. Conclusion The elevated level of sRAGE is associated with type 2 diabetes mellitus, but the polymorphism of RAGE is not. There is no significant association between polymorphism of SNPs in RAGE and sRAGE level.

Key words: Single nucleotide polymorphism, Type 2 diabetes mellitus, Soluble receptor for advanced glycation end products, Receptor for advanced glycation end products

CLC Number: 

  • R589
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