JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (1): 71-74.doi: 10.6040/j.issn.1671-7554.0.2013.537

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Association between Bax polymorphism and clinicopathologicalfeatures of breast cancer

BAI Yang1, CUI Guo-zhong1, DAI Dian-lu1, SANG Mei-xiang2, GENG Cui-zhi3   

  1. 1. Second Department of Tumor Surgery, Cangzhou Central Hospital, Cangzhou 061001, Hebei, China;
    2. Research Center, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China;
    3. Breast Center, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
  • Received:2013-09-02 Online:2014-01-10 Published:2014-01-10

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Abstract:

 Objective  To investigate the association between G(-248)A single nucleotide polymorphism (SNP) in pro-apoptosis gene Bax promoter and the clinicopathological features of breast cancer. Methods  The 3 genotypes (AA, AG, GG) of Bax G(-248)A SNP in 113 patients with breast cancer were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and the distributions of the 3 genotype frequency were compared. Results  The distribution of genotype AG+AA was notably lower than that of GG in tumor size T＞2cm, clinical stage II+III, positive lymph node metastasis and C-erbB2 protein expression, with statistically significant difference (P<0.05). There were no differences between the distributions of AG+AA genotype and GG genotype in pathological types, histological grade, estrogen receptor (ER) and progesterone (PR). Conclusion  The AG+AA genotype may be associated with smaller breast cancer, lower clinical stage, lower auxiliary lymph node metastasis rate, and negative C-erbB2 protein expression.

Key words: Bax, Breast neoplasm, Single nucleotide polymorphism

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