JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (4): 86-90.doi: 10.6040/j.issn.1671-7554.0.2016.1634

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Changes and clinical significance of serum adipokines in systemic lupus erythematosus

MA Zhenzhen, SUN Hongsheng, YANG Qingrui   

  1. Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250012, Shandong, China
  • Received:2016-12-08 Online:2017-04-10 Published:2017-04-10

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Abstract: Objective To investigate the expressions of adiponectin, visfatin and resistin in systemic lupus erythematosus(SLE), and to explore their role in SLE, lupus nephritis, and SLE complicated with bone necrosis. Methods A total of 58 SLE patients including 12 SLE complicated with bone necrosis and 46 SLE without bone necrosis, 23 lupus nephritis(LN)cases, 35 SLE cases without LN, were recruited. Another 43 healthy volunteers were selected as healthy controls. The serum levels of adiponectin, visfatin and resistin were detected with ELISA to analyze their relationship with renal injury and bone necrosis. The correlation between clinical and laboratory parameters was analyzed. Results Serum levels of adiponectin, visfatin and resistin were higher in SLE patients than in healthy controls(P<0.001). Adiponectin and resistin levels were significantly higher in LN cases than in SLE without LN cases(P<0.001, P=0.033). There were no differences in adiponectin, visfatin and resistin between the SLE patients with and without bone necrosis 山 东 大 学 学 报 (医 学 版)55卷4期 -麻贞贞,等.脂联素、内脂素、抵抗素在系统性红斑狼疮患者血清中的变化及临床意义 \=-(P=0.117, 0.058, 0.674, respectively). Visfatin was clearly associated with erythrocyte sedimentation rate(ESR)(rs=0.281, P=0.046). Body mass index(BMI)and ESR were the significant factors of visfatin(P=0.010, P=0.020), and BMI was the significant factor influencing resistin(P=0.046). Conclusion The high expressions of serum adiponectin, visfatin and resistin may be associated with SLE, and increased adiponectin and resistin levels correlate with renal damage, but the underlying mechanisms need further studies.

Key words: Systemic lupus erythematosus, Lupus nephritis, Visfatin, Resistin, Bone necrosis, Adiponectin

CLC Number: 

  • R593.24
[1] Schiller M, Lorenz HM. Pathogenesis of systemic lupus erythematosus[J]. Immunology Today, 2014, 35(8): 503-511.
[2] Bilir BE, Güldiken S, Tunçbilek N, et al. The effects of fat distribution and some adipokines on insulin resistance[J]. Endokrynol Pol, 2016, 67(3): 277-282.
[3] Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity[J]. Nat Rev Immunol, 2006, 6(10): 772-783.
[4] Lago F, Dieguez C, Gómez-Reino J, et al. The emerging role of adipokines as mediators of inflammation and immune responses[J]. Cytokine Growth Factor Rev, 2007, 18(3-4): 313-325.
[5] Rho YH, Solus J, Sokka T, et al. Adipocytokines Are Associated with Radiographic Joint Damage in Rheumatoid Arthritis[J]. Arthritis Rheumato, 2009, 60(7): 1906-1914.
[6] Syrbe U, Callhoff J, Conrad K, et al. Adipokine serum levels in patients with ankylosing spondylitis and their relation to clinical parameters and radiographic spinal progression[J]. Arthritis Rheumato, 2015, 67(3): 678-685.
[7] Evereklioglu C, Inalöz HS, Kirtak N, et al. Serum leptin concentration is increased in patients with Behçets syndrome and is correlated with disease activity[J]. Br J Dermatol, 2002, 147(2): 331-336.
[8] Eilertsen GØ, Becker-Merok A, Nossent JC. The influence of the 1997 updated classification criteria for systemic lupus erythematosus: epidemiology, disease presentation, and patient management[J]. J Rheumatol, 2009, 36(3): 552-559.
[9] Brochu-Gaudreau K, Rehfeldt C, Blouin R, et al. Adiponectin action from head to toe[J]. Endocrine, 2010, 37(1): 11-32.
[10] Neumeier M, Weigert J, Schäffler A, et al. Different effects of adiponectin isoforms in human monocytic cells[J]. J Leukoc Biol, 2006, 79(4): 803-808.
[11] Wolf AM, Dominik W, Holger R, et al. Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes[J]. Biochem Biophys Res Commun, 2004, 323: 630-635.
[12] Rovin BH, Song H, Hebert LA, et al. Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus[J]. Kidney Int, 2005, 68(4): 1825-1833.
[13] Berner HS, Lyngstadaas SP, Spahr A, et al. Adiponectin and its receptors are expressed in bone-forming cells[J]. Bone, 2004, 35(4): 842-849.
[14] Shuai B, Shen L, Yang YP, et al. Low plasma adiponectin as a potential biomarker for osteonecrosis of the femoral head[J]. J Rheumatol, 2010, 37(10): 2151-2155.
[15] Park HK, Qatanani M, Briggs ER, et al. Inflammatory induction of human resistin causes insulin resistance in endotoxemic mice[J]. Diabetes, 2011, 60(3): 775-783.
[16] Almehed K, DElia HF, Bokarewa M, et al. Role of resistin as a marker of inflammation in systemic lupus erythematosus[J]. Arthritis Res Ther, 2008, 10(1): 15.
[17] Baker JF, Morales M, Qatanani M, et al. Resistin levels in lupus and associations with disease-specific measures, insulin resistance, and coronary calcification[J]. J Rheumatol, 2011, 38(11): 2369-2375.
[18] Hutcheson J, Ye Y, Han J, et al. Resistin as a potential marker of renal disease in lupus nephritis[J]. Clin Exp Immunol, 2015, 179(3): 435-443.
[19] Bokarewa M, Nagaev I, Dahlberg L, et al. Resistin, an adipokine with potent proinflammatory properties[J]. J Immunol, 2005, 174(9): 5789-5795.
[20] Tarkowski A, Bjersing J, Shestakov A, et al. Resistin competes with lipopolysaccharide for binding to toll-like receptor 4[J]. J Cell Mol Med, 2010, 14(6B): 1419-1431.
[21] Lartigue A, Colliou N, Calbo S, et al. Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus[J]. J Immunol, 2009, 183(10): 6207-6216.
[22] 刘伦飞, 王建有, 劳力民, 等. SLE患者胰岛素抵抗和血清抵抗素水平研究[J]. 中华皮肤科杂志, 2009, 42(9): 593-595. LIU Lun Fei, WANG Jianyou, LAO Limin, et al. Insulin resistance and serum resistin levels in patients with systemic lupus erythematosus[J]. Chinese Journal of Dermatology, 2009, 42(9): 593-595.
[23] Elshishtawy H, Ibrahim ED, Helmi A, et al. Resistin in systemic lupus erythematosus: Relation to lupus nephritis and premature atherosclerosis[J]. Egyptian Rheumat, 2012, 34(4): 137-146.
[24] Hutcheson J, Ye Y, Han J, et al. Resistin as a potential marker of renal disease in lupus nephritis[J]. Clin Exp Immunol, 2015, 179(3): 435-443.
[25] Moschen AR, Kaser A, Enrich B, et al. Visfatin, an adipocytokine with proinflammatory and immunomodulating properties[J]. J Immunol, 2007, 178(3): 1748-1758.
[26] Ozgen M, Koca SS, Aksoy K, et al. Visfatin levels and intima-media thicknesses in rheumatic diseases[J]. Clin Rheumatol, 2011, 30(6): 757-763.
[27] Jia SH, Li Y, Parodo J, et al. Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis[J]. J Clin Invest, 2004, 113(9): 1318-1327.
[28] Fouda N, Abaza N, El-Hilaly R, et al. Evaluation of visfatin in patients with systemic lupus erythematosus: Correlation with disease activity and lupus nephritis[J]. World Pumps, 2012, 34(1): 9-17.
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