JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (4): 86-90.doi: 10.6040/j.issn.1671-7554.0.2016.1634

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Changes and clinical significance of serum adipokines in systemic lupus erythematosus

MA Zhenzhen, SUN Hongsheng, YANG Qingrui   

  1. Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250012, Shandong, China
  • Received:2016-12-08 Online:2017-04-10 Published:2017-04-10

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Abstract: Objective To investigate the expressions of adiponectin, visfatin and resistin in systemic lupus erythematosus(SLE), and to explore their role in SLE, lupus nephritis, and SLE complicated with bone necrosis. Methods A total of 58 SLE patients including 12 SLE complicated with bone necrosis and 46 SLE without bone necrosis, 23 lupus nephritis(LN)cases, 35 SLE cases without LN, were recruited. Another 43 healthy volunteers were selected as healthy controls. The serum levels of adiponectin, visfatin and resistin were detected with ELISA to analyze their relationship with renal injury and bone necrosis. The correlation between clinical and laboratory parameters was analyzed. Results Serum levels of adiponectin, visfatin and resistin were higher in SLE patients than in healthy controls(P<0.001). Adiponectin and resistin levels were significantly higher in LN cases than in SLE without LN cases(P<0.001, P=0.033). There were no differences in adiponectin, visfatin and resistin between the SLE patients with and without bone necrosis 山 东 大 学 学 报 (医 学 版)55卷4期 -麻贞贞,等.脂联素、内脂素、抵抗素在系统性红斑狼疮患者血清中的变化及临床意义 \=-(P=0.117, 0.058, 0.674, respectively). Visfatin was clearly associated with erythrocyte sedimentation rate(ESR)(rs=0.281, P=0.046). Body mass index(BMI)and ESR were the significant factors of visfatin(P=0.010, P=0.020), and BMI was the significant factor influencing resistin(P=0.046). Conclusion The high expressions of serum adiponectin, visfatin and resistin may be associated with SLE, and increased adiponectin and resistin levels correlate with renal damage, but the underlying mechanisms need further studies.

Key words: Systemic lupus erythematosus, Lupus nephritis, Visfatin, Resistin, Bone necrosis, Adiponectin

CLC Number: 

  • R593.24
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