JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (9): 71-79.doi: 10.6040/j.issn.1671-7554.0.2015.514

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Serum TK1 for the diagnosis of cancer in Chinese patients: a Meta-analysis

LIU Jingsheng1, LIU Guihua1, DU Kun1, ZHAO Qian2, WENG Shaobo1, ZHAO Xueying1, ZHANG Xizhuang1, JIN Xunbo3   

  1. 1. Department of Urology, North China Petroleum Administration Bureau General Hospital, Renqiu 062552, Hebei, China;
    2. Department of Pharmacy, North China Petroleum Administration Bureau General Hospital, Renqiu 062552, Hebei, China;
    3. Department of Minimally Invasive Urology Center, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2015-05-25 Online:2015-09-10 Published:2015-09-10
  • Contact: 金讯波。E-mail:16365451@qq.com E-mail:16365451@qq.com

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Abstract: Objective To evaluate significance of thymidine kinase 1 (TK1) detection in the diagnosis of malignant tumors in Chinese patients. Methods Clinical trials on TK1 detection published during Jan. 2008 to Mar 2015 were searched in databases of CNKI and Wan Fang. Revman 5.2 and Meta Disc 1.4 were used to perform the Meta-analysis.Results A total of 415 relevant articles were retrieved and 45 trials with 2,976 cancer patients (all diagnosed by the gold standard) were involved. Meta-analyses showed that the heterogeneity among studies was high, and the pooled Results suggested a moderate diagnostic efficacy. The sensitivities for lung cancer, breast cancer, gynecological cancer, prostatic cancer, gastric cancer, intestinal cancer and esophagus cancer were 0.508, 0.638, 0.524, 0.656, 0.583, 0.546, and 0.681, respectively. The specificities were 0.973, 0.932, 0.940, 0.925, 0.941, 0.947, and 0.967. Conclusion TK1 detection may have certain value in the early diagnosis and screening of malignant cancers, but it can not be serveed as an independent reference test. More high quality trials are required to confirm the significance of TK1 detection.

Key words: Thymidine kinase 1, Cancer, Specificity, Meta-analysis, Sensitivity

CLC Number: 

  • R730.4
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