JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (9): 79-84.doi: 10.6040/j.issn.1671-7554.0.2016.1668

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CT-guided 125I seed implantation for lymph node metastases in patients with gastric cancer of later stage

DI Xuemin, NIU Shulei, ZHAO Jing, DU Sui, YU Huimin, ZHANG Hongtao, WANG Juan   

  1. Department of Oncology, Hebei General Hospital, Shijiazhuang 050000, Hebei, China
  • Received:2016-12-16 Online:2017-09-10 Published:2017-09-10

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Abstract: Objective To evaluate the safety and effect of 125I seed implantation for lymph node metastases in patients with gastric cancer of Ⅲ-Ⅳ stage. Methods The data of 15 gastric cancer patients with lymph node metastases treated by CT-guided 125I seed implantation were retrospectively studied from January 2005 to May 2016. Lymph nodes with diameter ≤5 cm in six(33.3%)lesions, >5 cm were observed in nine(66.6%)lesions. Under CT guided implanted 125I seed with the activity of 0.3-0.7 mci,postplan was performed after the operation, the D90, V100, V150 pre and post operation were collected and compared. Six months after the treatment reexamination was employed, including lesion size changes and complications. Results The follow-up ranged from 6 to 18 months.The 6 -month local control was 93.3%, the effective rate was 73.3%, The 6-, 12- month of survival rates was 100% and 31%, respectively. The difference of all data between pre and post operation was not statistically significant(P=0.10, P=0.628, P=0.971)in the D90, V100, V150. No major complications such as massive hemorrhage, Gastric perforation,intestinal infection, bone marrow suppression, Reaction of skin and other related to the procedure occurred during the therapy. Conclusion CT guided radioactive 125I seed implantation for lymph node metastases in patients with gastric cancer of Ⅲ-Ⅳ stage was a safe and feasible method.

Key words: Brachytherapy, Lymph node metastases, Gastric cancer, Effect

CLC Number: 

  • R816.5
[1] Karpeh MS, Leon L, Klimstra D, et al. Brennan MFLymph node staging in gastric cancer: is location more important than Number? An analysis of 1,038 patients[J]. Ann Surg, 2000, 232(3): 362-371.
[2] Marrelli D, Roviello F, de Manzoni G, et al. Different patterns of recurrence in gastric cancer depending on Laurens histological type: longitudinal study[J]. World J Surg, 2002, 26(9): 1160-1165.
[3] Bang YJ, Kim YW, Yang HK, et al. Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy(CLASSIC): a phase 3 open-1abel,randomised controlled trial[J]. Lancet, 2012, 379(9813): 315-321.
[4] Van Cutsem E, de Haas S, Kang YK, et al. Bevacizumab in conbination with chemotherapy as first-line therapy in advanced gastric cancer: a biomarker evaluation from the AVAGAST randomized phase III trial[J]. J Clin Oncol, 2012, 30(17): 2119-2127.
[5] Yoo CH, Noh SH, Shin DW, et al. Recurrence following curative resection for gastric carcinoma[J]. Br J Surg, 2000, 87(2): 236-242.
[6] 高汝贵,李光,刘泰福,等.现代放射肿瘤学[M].上海:复旦大学出版社,2011: 381.
[7] Wang Z, Lu J, Gong J, et al. CT-guided radioactive 125I seed implantation therapy of symptomatic retroperitoneal lymph node metastases[J]. Cardiovasc Intervent Radiol, 2014, 37(1): 125-131.
[8] Gao F, Gu YK, Huang JH, et al. Clinical value of CT-guided 125I brachytherapy for retroperitoneal metastatic lymph node from PHC[J]. Zhonghua Yi Xue Za Zhi, 2013, 93(27): 2155-2157.
[9] Liu B, Zhou T, Li Y, et al. Percutaneous computed tomography-guided iodine-125 seeds implantation for unresectable pancreas[J]. Indian J Cancer, 2015, 52(2): 69-74.
[10] Park JO, Lee SI, Song SY, et al. Measuring response in solid tumors: comparison of RECIST and WHO response criteria[J]. Jpn J Clin Oncol, 2003, 33(10): 533-537.
[11] 严广斌.NRS疼痛数字评价量表numerical rating scale[J/CD]. 中华关节外科杂志,2014,8(3): 410-410. YAN Guangbin. Numerical rating scale[J]. J Joint Surgery(Electronic Version), 2014, 8(3): 410-410.
[12] Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources,methods and major patterns in GLOBOCAN 2012[J]. Int J Cancer, 2015, 136(5): 359-386.
[13] Han DS, Suh YS, Kong SH, et al. Nomogmm predicting long-term survival after d2 gastrectomy for gastric cancer[J]. J Clin Oncol, 2012, 30(31): 3834-3840.
[14] Deng J, Liang H, Wang D, et al. Investigation of the recurrence patterns of gastric cancer following a curative resection[J]. Surg Today, 2011, 41(2): 210-215.
[15] Bang YJ, Kim YW, Yang HK, et al. CLASSIC trial investigators. Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy(CLASSIC): a phase 3 open-1abel, randomised controlled trial[J]. Lancet, 2012, 379(9813): 315-321.
[16] 吴晖,张信华,徐建波,等.进展期胃癌腹主动脉旁淋巴结转移的相关因素及其对预后的影响[J/CD].消化肿瘤杂志,2012,4(2):82-88. WU Hui, ZHANG Xinhua, XU Jianbo, et al. Influencing factors and prognostic impact of para-aortic lymph nodes metastasis in advancedgastric cancer[J/CD]. J Dig Oncol(Electronic Version), 2012, 4(2): 82-88.
[17] 张佳佳,梁振威,李颖,等.SiewertⅡ型和Ⅲ型局部晚期胃食管交界处腺癌根治术后淋巴结复发规律分析[J].中华放射肿瘤学杂志,2016,25(4): 356-361. ZHANG Jiajia, LIANG Zhenwei, LI Ying, et al. Pattern of nodal recurrence after curative resection in Siewert Ⅱ and Ⅲ locally advanced adenocarcinoma of gastroesophageal junction[J]. Chin J Radi Oncol, 2016, 25(4): 356-361.
[18] Deng J, Zhang R, Wu L, et al. Superiority of the ratio between negative and positive lymph nodes for predicting the prognosis for patients with gastric cancer[J]. Ann Surg Oncol, 2015, 22(4): 1258-1266.
[19] Chen L, Wei S, Ye Z, et al. Analysis of risk factors and prognosis of No.8p lymph node metastasis in cases with advanced gastric cancer[J]. Zhonghua Wei Chang Wai Ke Za Zhi, 2017, 20(2): 218-223.
[20] Dai Y, Jiang J, Wang Y, et al. The correlation and clinical implication of VEGF-C expression in microvascular density andlymph node metastasis of gastric carcinoma[J]. Am J Transl Res, 2016, 8(12): 5741-5747.
[21] Yao L, Jiang Y, Jiang P, et al. CT-guided permanent 125I seed interstitial brachytherapy for recurrent retroperitoneal lymph node metastases after external beam radiotherapy[J]. Brachytherapy, 2015, 14(5): 662-669.
[22] Hori N, Kagawa S, Kikuchi S, et al. Multiple salvage radiotherapies for metachronous lymph node metastasis from gastric cancer contributed to long-term management of disease[J]. Gan To Kagaku Ryoho, 2017, 44(2): 165-167.
[23] 石亮荣,吴骏周,文杰,等.CT引导125I粒子植入术治疗胃癌术后区域淋巴结转移[J].中华核医学与分子影像杂志,2013,33(4):243-248. SHI Liangrong, WU Junzhou, WEN Jie, et al. CT-guided 125I seed implantation for Iocoregional lymph node metastases in pafients with recurrent gastric cancer[J]. Chinese Journal of Nuclear Medicine and Molecular Imaging, 2013, 33(4): 243-248.
[24] 王娟,孙美玲,张宏涛,等.外放疗后复发颈部淋巴结转移癌17例125I粒子植入治疗的初步疗效[J].介入放射学杂志,2014,23(9): 784-787. WANG Juan, SUN Meiling, ZHANG Hongtao, et al. Radioactive 125I seed implantation for the treatment of recurrent cervical lymphatic metastases after radiotherapy: preliminary results in 17 cases[J]. Journal of Interventional Radiology, 2014, 23(9): 784- 787.
[25] Wang Z, Lu J, Gong J, et al. CT-guided radioactive 125I seed implantation therapy of symptomatic retroperitoneal lymph node metastases[J]. Cardiovasc Intervent Radiol, 2014, 37(1): 125-131.
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