Table of Content

  

10 September 2017
Volume 55 Issue 9

Review of mental health assessment of the elderly based on different theoretical models

PAN Fang

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  1-5.  doi:10.6040/j.issn.1671-7554.0.2017.472

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China entered the aging society in the year 2012, in which people aged ≥60 years accounted for 10% of the total population. In order to meet the needs of life care, health care and rehabilitation care, as well as to provide professional service, it is necessary to evaluate the mental health status of the elderly. At present, there exist different mental health standards and assessment methods based on multiply theoretical models. This article reviews the standards of psychological health and evaluation methods based on pathological psychology, mental health, positive psychology and positive aging.

Relationship between quality of life and perceived social support and the mediating effect of resilience in old people

LI Changjin, HONG Wei, ZHAO Jia, GAN Wei

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  6-10.  doi:10.6040/j.issn.1671-7554.0.2016.1407

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Objective To explore the relationship between quality of life and resilience, and to analyze the mediating effect of perceived social support. Methods A total of 445 old people were surveyed with Perceived Social Support Scale(PSSS), Connor-Davidson Resilience Scale(CD-RISC 10)and WHO Quality of Life-BREF(WHOQOL-BREF). Results There was significantly positive correlation between perceived social support, resilience and quality of life, respectively(P<0.01). Both perceived social support and resilience predicted the quality of life(β=0.333, β =0.415). Bootstrap test showed that perceived social support partly mediated between quality of life and resilience, and the mediating effect was 0.160 7(95%CI: 0.1120-0.2184). Conclusion Perceived social support plays a mediating role between resilience and quality of life.

A study of happiness, stress and mental resilience of elderly of different ages

JIANG Hong, XU Jingjing, WANG Rui, YI Xiangren, ZHOU Yaru, PAN Fang

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  11-16.  doi:10.6040/j.issn.1671-7554.0.2016.1415

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Objective To explore the happiness, stress and mental resilience of elderly of different ages. Methods A total of 622 elderly aged over 60 years who lived in the same community were investigated with the Face Scale, Perceived Stress Scale(PSS)and Connor-Davidson Resilience Scale(CD-RISC). Results The happiness of elderly displayed dynamic changes with aging, the 60- year group had the highest happiness, the 65- year group had declining happiness, and the 70- year group had the lowest happiness, which then remained at a low level with aging. The 80- year group had the lowest stress compared with other groups. The 60- year group and 65- year group had significantly higher scores of CD-RISC than the 80- year group and >85-year group. Elderly with good physical health, living with spouse and good income had high level of happiness. The divorced group had the highest stress score, and the moderate-income group had the best mental resilience. Age, marital status, income, physical health and mental resilience were significantly 山 东 大 学 学 报 (医 学 版)55卷9期 -江虹,等.不同年龄阶段老年人的幸福感、心理压力与心理弹性研究 \=-correlated with happiness, among which mental resilience had the greatest effect. Age, income, physical health and stress were significantly related to mental resilience, among which stress had the greatest effect. Marital status, physical health and mental resilience were the predicators of happiness. Gender, physical health and stress were the predicators of mental resilience. Conclusion Happiness of elderly changes dynamicly with aging. Elderly with higher mental resilience have higher level of happiness. Stress and physical health can reduce resilience, which influences the level of happiness.

Age-related changes and influencing factors of loneliness and social support in urban elderly

JIANG Hong, XU Jingjing, WANG Rui, ZHOU Yaru, YI Xiangren, PAN Fang

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  17-22.  doi:10.6040/j.issn.1671-7554.0.2016.1103

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Objective To investigate the loneliness, social supports of urban elderly and the influencing factors. Methods A total of 622 healthy people over 60 years were enrolled. All subjects filled in the general information questionnaires, the loneliness scale and perceived social support scale of University of California, Los Angles(UCLA). Results In the different age groups, the 75-year group had the lowest loneliness score, while the 80-year group had the highest. Social support within family decreased at the age of 75, and the 80-year group had lowest levels of social support and support within family. In the different income groups, the high-income group had the highest loneliness score, and the moderate-income group had the highest social support within family. In the different marital status groups, the divorced group had significantly higher loneliness score compared with ordinary group and widowed group. Meanwhile, the divorced and widowed groups had less social support and support within family. In the different health status groups, the general-health group and poor-health group had significantly higher loneliness scores and less support within 山 东 大 学 学 报 (医 学 版)55卷9期 -江虹,等.城市老年人的孤独感与社会支持的增龄性变化及影响因素 \=-family than the good-health group. Loneliness was positively associated with low income, unhappy marriage and poor health, and negatively correlated with social support. Age, gender, family income, health condition and support within and outside family had significant prediction effects on loneliness. Conclusions Loneliness of urban elderly changes along with aging, which is correlated with income, marital status, health condition and social support. Age, gender, family income, health condition and social support are predictors of loneliness.

The therapeutic efficacy of a potent KSP inhibitor S(MeO)TLC against docetaxel-resistant prostate cancer

DONG Wei, XING Naidong, LÜ Jiaju, LIU Shuai, SUN Liang, CAO Qingwei, DONG Yuhao, LIU Zhao, DING Sentai

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  23-30.  doi:10.6040/j.issn.1671-7554.0.2017.145

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Objective To investigate the therapeutic effect of S(MeO)TLC which targetedly inhibits KSP(Eg5)on docetaxel-resistant prostate cancer in vitro. Methods Docetaxel-resistant PC3 cells(PC3R)were developed by chronic, repeated exposure to docetaxel through gradient culture. IC₅₀ of docetaxel-resistant cells to docetaxel was assessed with MTT assay. KSP expressions of different prostate cancer cell lines(PC3, DU145, PC3R)were examined with Western blotting. The cells were divided into control group, PC3 group and PC3R group, and the anti-proliferative activity of S(MeO)TLC was analyzed with MTT and trypan blue staining. After that, the PC3R cells were divided into 山 东 大 学 学 报 (医 学 版)55卷9期 -董伟,等.靶向抑制有丝分裂驱动蛋白治疗多西紫杉醇耐药前列腺癌的体外疗效 \=-control group and S(MeO)TLC group, and the apoptosis was investigated with Hoechst nuclear staining, flow cytometry and RT-PCR in vitro. Results The expressions of KSP in PC3, DU145, and PC3R were similar, with no statistical difference(P>0.05). There was no significant difference in IC50 between PC3R(120 nmol/L)and PC3(106 nmol/L)(P>0.05). After S(MeO)TLC treatment for 24 hours, 87.9% PC3R cells were in the mitosis phase, most of which went apoptosis after 72 hours of S(MeO)TLC treatment. Compared with the control group, PC3R group had significantly increased expressions of Caspase-3(t=13.445, P=0.000 2), Caspase-8(t=9.494, P=0.000 7), Caspase-9(t=5.198, P=0.007), PARP(t=19.097, P=0.000 04), LC3(t=22.609, P=0.000 02)and Beclin1(t=61.266, P=0.000 000 4). Conclusion The resistance of prostate cancer to docetaxel is not related to KSP expression. S(MeO)TLC, as a new KSP/Eg5 inhibitor, has shown obvious anticancer efficacy in docetaxel-resistant prostate cancer cell lines in vitro by inducing cell apoptosis, in which both endogenous and exogenous caspase-dependent apoptotic pathways play an important role, while autophagy plays a synergistic role.

Effect of MnSOD acetylation on the proliferation and apoptosis of clear cell renal cell carcinoma cell line 786-O

ZHAO Zuohui, LI Cuiling, WANG Daoguang, WANG Fengqin, QU Hongyi, DING Sentai, GONG Jing, LÜ Jiaju, YANG Jinghua

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  31-35.  doi:10.6040/j.issn.1671-7554.0.2016.1604

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Objective To investigate the deacetylation of manganese superoxide dismutase(MnSOD)regulated by silent information regulator 2-related enzymes(SIRT 3)in 786-O, a clear cell renal cell carcinoma(ccRCC)cell line, and its subsequent influences on cell proliferation and apoptosis viability. Methods Western blotting and immunoprecipitation 山 东 大 学 学 报 (医 学 版)55卷9期 -赵作辉,等.MnSOD乙酰化对肾透明细胞癌786-O细胞增殖、凋亡的影响 \=-(IP)were employed to confirm MnSOD acetylation in 786-O cells. Superoxide dismutase(SOD)activity kit, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay and Hoechst fluorescence staining solution were used to measure MnSOD enzymatic activity, cell proliferation and apoptosis viability, respectively. Results Compared with plasmid empty vector(pcDNA3.0), SIRT 3(pcDNA3.0-sirt3)deacetylated mitonchondrial MnSOD from 1.29±0.16 to 0.74±0.07 in 786-O cells(t=7.21, P<0.001), enhanced its enzymatic activity from(1.47±0.17)U/mg to(2.53±0.31)U/mg(t=6.70, P<0.001), increased cell proliferation rate from(25.28±5.75)% to(48.86±7.47)%(t=5.60, P<0.001), whereas cell apoptosis rate changed from(4.53±0.51)% to(4.45±0.59)%, which remained stable(t=0.24, P=0.82). Conclusion MnSOD deacetylation enhances the proliferation activity of ccRCC cell line 786-O, which indicates that MnSOD or its acetylation might be a potential therapeutic target for RCC.

Expressions of PARP-1 and EMT markers in eutopic and ectopic endometrium of adenomyosis

LIN Xueyan, LI Chunyan, HOU Xiaoman, TIAN Yongjie

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  36-40.  doi:10.6040/j.issn.1671-7554.0.2017.072

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Objective To detect the expression of poly(ADP-ribose)polymerase-1(PARP-1)in eutopic and ectopic endometrium of women with adenomyosis and to investigate the correlation between PARP-1 and epithelial-mesenchymal transition(EMT)markers in eutopic and ectopic endometrium of women with adenomyosis. Methods The expressions of PARP-1 and EMT markers, including E-cadherin, vimentin and Snail, were detected by immunohistochemistry in eutopic and ectopic endometrium of women with adenomyosis and in eutopic endometrium of women without adenomyosis. The correlation between PARP-1, E-cadherin, vimentin and Snail expression levels were analyzed by Spearman correlation analysis. Results The expressions of PARP-1, vimentin and Snail in eutopic and ectopic endometrium with adenomyosis were significantly higher than those in the normal endometrium with adenomyosis(all P<0.05). The expression of E-cadherin in eutopic and ectopic endometrium with adenomyosis were significantly lower than that in the normal endometrium(all P<0.05). In the lesions of the eutopic and ectopic endometrium with adenomyosis, the expression level of PARP-1 was negatively correlated with E-cadherin, while positively correlated with vimentin and Snail. Conclusion PARP-1 is highly expressed in eutopic and ectopic endometrium of women with adenomyosis and is related with EMT markers. PARP-1 may be involved in the EMT process of adenomyosis.

Improvement of pediocin yield by a novel high residual sugar and re-alkalized feeding strategy

QIN Lumin, SUN Aiyou, WANG Qianwen, GAO Jingwen, WEI Dongzhi

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  41-45.  doi:10.6040/j.issn.1671-7554.0.2016.1656

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Objective To improve the pediocin yield by designing a novel high residual sugar and re-alkalized feeding(F4)strategy. Methods (1) The initial glucose concentration was 8.8 g/L in the first phase; (2) When the residual glucose concentration was lower than 2 g/L, the second phase started, and the glucose concentration kept about 20 g/L in the whole second phase; at the same time, the pH values of fermentation broth were raised to 6.5 every 6 h, which make the pH value re-alkalize repeatedly. Results The max titer of pediocin reached 24 000 AU/mL in the optimized feeding strategy F4. The pediocin yield of F4 strategy is 3, 3, and 1.7 times of F1, F2 and F3 strategies. Conclusion F4 strategy can not only increase the cell concentration, but also improve the yield of pediocin, which is suitable for mass production of pediocin.

Impact of autophagy on targeting imaging of allorejection with ¹²⁵I-anti-TLR5

ZHAO Shanshan, LI Xiaomei, LIANG Ting, ZHANG Chao, SONG Jing, HOU Guihua

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  46-52.  doi:10.6040/j.issn.1671-7554.0.2017.030

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Objective To evaluate the effect of autophagy on targeting imaging of allotransplanted skin graft by ¹²⁵I-anti-TLR5. Methods Mouse alloskin transplantation models were established and divided into 4 groups: control group, rapamycin group, 3-Methyladenine(3MA)group, and rapamycin+3MA group. Anti-TLR5 was labeled with ¹²⁵I by Iodogen method, and stability in normal saline and serum was determined respectively. Spleen cells were divided into control group, rapamycin group(10 ng/mL), 3MA group(10 mmol/L)and rapamycin+3MA group(10 ng/mL rapamycin+10 mmol/L 3MA). Then the uptake and dissociation of ¹²⁵I-anti-TLR5 were studied. ¹²⁵I-anti-TLR5 was injected to transplantation models through tail veins on day 9 after allotransplantation. Biodistribution at 72 h after 山 东 大 学 学 报 (医 学 版)55卷9期 -赵姗姗,等.自噬对¹²⁵I-anti-TLR5同种移植排斥靶向显像的影响 \=-¹²⁵I-anti-TLR5 injection and whole-body phosphor-autoradiography at 24 h, 48 h, and 72 h were performed. T/NT ratio(target to non-target)was analyzed. Beclin1/TLR5 expression was detected with histological and immunohistochemical staining. Results ¹²⁵I-anti-TLR5 was successfully obtained with good labeling rate and stability. The uptake and dissociation of tracer were not apparently changed in rapamycin+3MA group compared with rapamycin group. Biodistribution studies showed that ¹²⁵I-anti-TLR5 was mainly metabolized through the liver and kidney, and high radioactivity in grafted skin was detected. The T/NT ratio in rapamycin group and rapamycin+3MA group was significantly higher than that in control group(P<0.001, P<0.001). Whole body phosphor-screen autoradioimaging showed clear skin grafts radioactivity-imaging in rapamycin group at 48 h compared with the control group(P<0.001). Radioactivity activity ratio of rapamycin group and rapamycin+3MA group remarkably increased(P<0.001)at 72 h. Allograft histology assay showed that acute inflammatory infiltration was decreased in rapamycin group and rapamycin+3MA group. The expression of Beclin1 was not significantly decreased in rapamycin+3MA group compared with the control group and rapamycin group. TLR5 expression was not significantly changed in rapamycin group and rapamycin+3MA group. Conclusion Autophagy has no significant impact on TLR5 expression and ¹²⁵I-anti-TLR5 targeted allograft rejection imaging under rapamycin application and ¹²⁵I-anti-TLR5 could be used for allograft imaging under rapamycin-induced tolerance.

Construction and appraisal of hyaluronic acid hydrogel scaffold in the treatment of treat spinal cord injury

LIU Dong, ZHU Dongyun, PENG Changliang, ZHANG Cheng, ZHAO Jie, GAO Chunzheng

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  53-59.  doi:10.6040/j.issn.1671-7554.0.2017.061

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Objective To evaluate the role of hyaluronic acid(HA)scaffold modified with Nogo-66 receptor(NgR)antibody and poly-l-lysine(PLL), and to determine whether endothelial progenitor cells(EPCs)transfected with β nerve growth factor(β-NGF)could stably express exogenous gene in stent. Methods The NgR antibody and PLL were grafted to the porous HA hydrogel scaffold which was produced by freeze drying method. In vitro study, the EPCs were isolated from Wistar rats, and then β-NGF was transfected to EPCs by recombinant adenovirus. EPCs were then cultured on the HA hydrogel scaffold, and the internal structure of the HA hydrogel scaffold was observed with scanning electron microscope. EPCs were divided into β-NGF⁺ group, Scaffold-β-NGF⁺ group, β-NGF^- group, Scaffold-β-NGF^- group, control group and Scaffold-control group. The growth of the EPCs cultured on the scaffold was determined with cell vitality detection(CCK-8)and HE. The cytotoxicity of HA hydrogel scaffold was detected with lactate dehydrogenase(LDH). The expression of β-NGF was detected with Rt-PCR, Western blotting and enzyme-linked 山 东 大 学 学 报 (医 学 版)55卷9期 -刘东,等.脊髓损伤修复的复合透明质酸水凝胶支架的构建及其评价 \=-immunosorbent(ELISA)assays in vitro. Results The aperture size of the porous three-dimensional structure of HA hydrogel scaffold was(200±15)μm. The EPCs grew better on the scaffold(F=468 518.044, P<0.001). There existed significant difference over time in the number of cells(F=2 678 658.138, P<0.001). There was no difference in cytotoxicity between HA scaffold and culture plate(F=0.680, P=0.429). EPCs could stably express β-NGF on the scaffold, and the mRNA and protein expressions of β-NGF in the Scaffold-β-NGF⁺ group were better than those in the β-NGF⁺ group(mRNA: F=651.554, P<0.001; β-NGF: F=14 671.733, P<0.001). Conclusion EPCs and the newly created HA hydrogel scaffold modified with NgR antibody and PPL have a good biocompatibility. This scaffold may serve as an optimal biomaterial for tissue engineering in spinal cord injury repair.

Therapeutic effect of astragalus polysaccharides/chitosan microspheres on rats with allergic rhinitis

SUN Yuqing, LI Wentao, LIU Kang, ZHAO Limin, ZHANG Weifen

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  60-65.  doi:10.6040/j.issn.1671-7554.0.2016.015

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Objective To explore the therapeutic effect of astragalus polysaccharides/chitosan microspheres on rats with allergic rhinitis. Methods Astragalus polysaccharides/chitosan microspheres were prepared with spray drying method, and the physicochemical properties of microspheres were characterized by drug loading, particle size and morphology. A total of 60 healthy Wistar rats were randomly divided into the following groups: normal group, model group, budesonide group, astragalus polysaccharides/chitosan microspheres low-dose group, moderate-dose group and high-dose group. Allergic rhinitis rat models were built by intraperitoneal injection of aluminum hydroxide gel and intranasal administration of ovalbumin. The budesonide group was given budesonide solution by continuous nasal administratio; the polysaccharides/chitosan microspheres low-dose group, moderate-dose group and high-dose group were treated with saline solution of astragalus polysaccharide/chitosan microspheres with different dosages; the model group and normal group were treated with normal saline. The effects of the drugs on syndrome scores and pathological changes were observed. Results The symptoms of allergic rhinitis and pathological changes were effectively inhibited or reduced by 山 东 大 学 学 报 (医 学 版)55卷9期 -孙玉卿,等.黄芪多糖/壳聚糖缓释微球对大鼠变应性鼻炎的治疗作用 \=-astragalus polysaccharides/chitosan microspheres. Conclusion The astragalus polysaccharides/chitosan microspheres have significant therapeutic effect on allergic rhinitis in rats.

Human stromal vascular fraction combined with adipose stem cells promotes the healing of radiation skin damage in nude mice

ZHU Lin, LI Weiwei, LIU Zhikai

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  66-72.  doi:10.6040/j.issn.1671-7554.0.2017.024

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Objective To evaluate the effects of stromal vascular fraction(SVF)combined with adipose stem cells(ASCs)transplantation on the healing of radiation skin damage in nude mice. Methods SVF and ASCs were extracted from the fat tissues of healthy adult women. The wound models were randomly divided into 4 groups: SVF+ASCs group, SVF group, ASCs group and sham group. The healing of wounds was observed on day 7 and 14. On day 14, samples were collected. The inflammatory reaction was observed with HE dying. The distribution of CD31 positive cells was determined with immunohistochemical staining. The distribution of collagen was observed with Masson staining. Results On day 14, wounds of the SVF+ASCs group were completely healed; wounds of the control group still showed granulation tissues; wounds of ASCs and SVF groups were largely unhealed. The count of inflammatory cells was lower in SVF+ASCs group than in ASCs group, SVF group and control group. Count of CD31 cells was significantly higher in SVF+ASCs group than in the other 3 groups. The collagen arrangement was more organized in SVF+ 山 东 大 学 学 报 (医 学 版)55卷9期 -朱琳,等.人血管基质片段联合脂肪干细胞促进裸鼠放射性皮肤损伤的愈合 \=-ASCs group than in the other 3 groups. Conclusion The SVF+ASCs transplantation can promote the healing of radiation skin damage innude mice and may be widely spread in clinical practice.

Clinicopathological factors and prognosis between primary central and peripheral lung squamous cell carcinoma

LI Xingkai, LIU Zhanye, JIANG Yunfeng, LI Jun

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  73-78.  doi:10.6040/j.issn.1671-7554.0.2016.1387

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Objective To study the clinicopathological features and the prognosis of primary lung squamous cell carcinoma retrospectively and to provide effective methods for diagnosis and treatment. Methods A retrospective study of the clinical data of 447 primary lung cancer patients from January 2009 to December 2012 was made, including 173 cases of central squamous carcinoma and 274 cases of peripheral lung squamous carcinoma. Students t test, Pearson chi-square test, and parametric test of rank transformation were conducted to identify whether there is a significant difference in the clinicopathological factors between central or peripheral lung squamous cell carcinoma. The survival curve was drawn by Kaplan-Meier method, while different survival curves were compared by Log-rank method. Results The difference of sex, age, pathological features, surgical methods, lymph node metastasis of different tumor diameter and differentiated degree, prognosis of lymph node metastases staging were statistically significant. The 1, 3 and 5 year 山 东 大 学 学 报 (医 学 版)55卷9期 -李星凯,等.原发性中央型和周围型肺鳞癌临床病理学及预后差异 \=-survival rate of central squamous carcinomas was 92.70%, 53.60% and 33.76% respectively, and that of peripheral squamous carcinoma was 97.11%, 70.72% and 40.81%. The prognosis between central and peripheral lung squamous cell carcinoma was significantly different(χ2=9.561, P<0.001). Conclusion The constituent ratio between the male and the female showed statistical difference in peripheral and central lung squamous cell carcinoma. Compared with peripheral lung squamous cell carcinoma, central type had a higher rate of lymph node metastasis, poorer prognosis and youth oriented tendency. In addition, it revealed that the rate of lymph node metastasis was positively related with an increasing size and poorer differentiation of the tumor.

CT-guided ¹²⁵I seed implantation for lymph node metastases in patients with gastric cancer of later stage

DI Xuemin, NIU Shulei, ZHAO Jing, DU Sui, YU Huimin, ZHANG Hongtao, WANG Juan

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  79-84.  doi:10.6040/j.issn.1671-7554.0.2016.1668

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Objective To evaluate the safety and effect of ¹²⁵I seed implantation for lymph node metastases in patients with gastric cancer of Ⅲ-Ⅳ stage. Methods The data of 15 gastric cancer patients with lymph node metastases treated by CT-guided ¹²⁵I seed implantation were retrospectively studied from January 2005 to May 2016. Lymph nodes with diameter ≤5 cm in six(33.3%)lesions, >5 cm were observed in nine(66.6%)lesions. Under CT guided implanted ¹²⁵I seed with the activity of 0.3-0.7 mci,postplan was performed after the operation, the D90, V100, V150 pre and post operation were collected and compared. Six months after the treatment reexamination was employed, including lesion size changes and complications. Results The follow-up ranged from 6 to 18 months.The 6 -month local control was 93.3%, the effective rate was 73.3%, The 6-, 12- month of survival rates was 100% and 31%, respectively. The difference of all data between pre and post operation was not statistically significant(P=0.10, P=0.628, P=0.971)in the D90, V100, V150. No major complications such as massive hemorrhage, Gastric perforation,intestinal infection, bone marrow suppression, Reaction of skin and other related to the procedure occurred during the therapy. Conclusion CT guided radioactive ¹²⁵I seed implantation for lymph node metastases in patients with gastric cancer of Ⅲ-Ⅳ stage was a safe and feasible method.

A study of 11β-hydroxylase defect induced by a novel CYP11B1 gene mutation in one family

LIU He, LIU Fuqiang, HOU Xinguo, CHEN Li

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  85-89.  doi:10.6040/j.issn.1671-7554.0.2017.218

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Objective To study the clinical features and the results of CYP11B1 gene analysis of a Chinese adult with classical 11β-hydroxylase deficiency. Methods One case diagnosed with classical 11β-hydroxylase deficiency in our department in 2016 was enrolled in this study. The clinical characteristics, diagnosis, treatment and gene analysis were reported and the related literature was reviewed. Results The male patient, 29 years old, paroxysmal paralysis for more than 20 years with accelerated skeletal maturation, resultant short stature and peripheral precocious puberty. CT showed bilateral adrenal occupying lesions. Laboratory examinations found plasma ACTH 301.70 pg/mL,serum 17α-hydoxy progesterone 23.83 ng/mL, testosterone 997.04 ng/dL, dehydroepiandrosterone sulfate 921.70 g/dL, androstenedione >10.30 ng/mL, orthostatic renin activity 1.90 μIU/(mL·h), aldosterone / renin activity 0.72. Dexamethasone 0.75 mg/d(bedtime)combined with compound reserpine triamterene tablets was given to the patient which effectively inhibit ACTH and androgen levels and blood pressure. A novel splicing mutation c.595+1G>A was identified in CYP11B1 gene of the patient. The mutation of the patient was homozygous and his mother and sister was heterozygous, while his father was not identified with this mutation. Conclusion Glucocorticoid combined with reserpine triamterene tablets can be used in the classical 11β-hydroxylase deficiency. A novel homozygous mutation c.595+1G>A was related to the classical phenotype.

Regulating effect of Bailing capsule on autoimmunity in patients with Graves disease

LIU Pan, HE Tianyi, ZHAO Ruxing, SUN Yu, CHEN Li

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  90-95.  doi:10.6040/j.issn.1671-7554.0.2016.172

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Objective To investigate the regulating effect of Bailing capsule on autoimmunity in patients with Graves disease(GD). Methods Eighty-four patients with GD were divided into the control group(n=42), which was treated with methimazole, and the experimental group(n=42), which was treated with methimazole combined with Bailing capsule(2 grams each time, three times a day)for 6 months. The levels of thyroid function(FT3, FT4, TSH), antithyroid peroxidase antibody(TPO-Ab), thyrotrophin receptor antibody(TR-Ab ), and subsets of T-lymphocytes(CD3⁺, CD4⁺, CD8⁺ and CD4⁺/CD8⁺)were measured before treatment, and 1 months, 3 months, and 6 months after treatment. Results (1) The thyroid function of the two groups had no statistical difference after treatment(P>0.05); (2) After treatment, the levels of TPO-Ab and TR-Ab in the experimental group were lower than pretherapy(P<0.001); compared with the control group,the Abs also decreased significantly(P<0.001); (3) course of treatment could influence the level of TR-Ab; (4) After six months of treatment, the CD4⁺ T cells in the experimental group decreased(P=0.003), CD8⁺ T cells increased(P=0.046), and CD4⁺/CD8⁺ decreased(P=0.027)markedly than the control group. Conclusion The Bailing capsule can effectively decrease the levels of TPO-Ab and TR-Ab in GD patients, and regulate the cellular immune functions, accordingly improve the immune disorder.

Efficacy and safety of foscarnet in the treatment of hematonosis complicated with Epstein-barr virus infection

ZHAO Wenbo, ZHEN Changqing, YUAN Dai, SHAN Ningning, WANG Na, FENG Lili, LI Peipei, DING Mei, LI Ying, ZHANG Lingyan, WANG Xin

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  96-99.  doi:10.6040/j.issn.1671-7554.0.2016.1024

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Objective To investigate the efficacy of foscarnet in the treatment of hematonosis plus Epstein-barr virus(EBV)infection. Methods The clinical data of 112 cases of hematonosis complicated with EBV infection treated during Jan. 2014 and Oct. 2015 were retrospectively analyzed, including 70 males and 42 females. The patients were divided into malignant group(n=84)and non-malignant group(n=18). Based on the presence of cytomegalovirus(CMV)infection and bone marrow transplantation, the malignant group was subdivided into 4 groups: simple EBV group, EBV plus CMV group, chemotherapy group, and bone marrow transplantation group. All patients were given 山 东 大 学 学 报 (医 学 版)55卷9期 -赵文博,等.膦甲酸钠治疗血液病患者合并EB病毒感染的临床疗效 \=-foscarnet 60 mg/kg per 12 hours for 14 days. Peripheral blood samples were collected weekly for blood routine test, DNA quantity of EBV and liver-kidney function analysis, to evaluate the effect and adverse reactions of the treatment. Results The total effective rate was 72.3%, which was 72.3% and 72.2% respectively for the malignant group and non-malignant group, with no statistical difference(P>0.05). There was no statistically significant difference in the effective rate between male and female groups and different age groups(P>0.05). In the malignant group, EBV plus CMV group had higher effective rate than the simple EBV group, with statistically significant difference(P<0.05), while there was no difference between the chemotherapy group and bone marrow transplantation group(P>0.05). The copies of DNA of EBV decreased after treatment. The median time for effectiveness was 10.3 to 14.5 days. Adverse reactions such as nausea and palpitation were observed, but all were tolerable. Conclusion Foscarnet is safe and effective in the treatment of EBV infection in patients with malignant hematonosis, with a few tolerable adverse reactions.

Influence of abortion and family heredity history on the risk of uterine leiomyomas

GONG Zhuo, ZHANG Minmin, WANG Zhiping

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  100-104.  doi:10.6040/j.issn.1671-7554.0.2017.123

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Objective To explore the influence of abortion and family heredity history on the risk of uterine leiomyomas, and to provide suggestions for preventing uterine leiomyomas. Methods A case-control study was undertook in this study. A structural questionnaire survey was used collecting the information of abortion experience, family history of uterine leiomyomas, age, height and other information among 20-65 years old married women from 10 urban and rural areas in Shandong province, China. The relations between both abortion experience, family history of uterine leiomyomas and uterine leiomyomas were analyzed by using Logistic regression model. Relative excess risk of interaction, attributable proportion of interaction and synergy index were used evaluating the interaction of abortion and family history of uterine leiomyomas. Results Results from multivariate unconditional Logistic regression model showed that abortion(OR=1.39, 95%CI: 1.06-1.80)and family heredity history of uterine leiomyomas(OR=2.07, 95%CI: 1.36-3.15)were risk factors of uterine leiomyomas. There was an addictive interaction of abortion and family heredity history on the risk of uterine leiomyomas (S=5.51, AP=0.59, RERI=2.14). Patients who had family heredity history and who had one or two more abortion increased the risk of uterine leiomyomas by 1.78 times and 2.77 times respectively. Conclusion Women who have family heredity history of uterine leiomyomas should pay attention to the pregnant plan and prevent abortion in order to reduce the risk of uterine leiomyomas.

Mediating role of perceived stress on the relationship between mindfulness level and psychological distress among infertile women

KANG Xiaofei, FANG Yueyan, ZHAO Di, FENG Xiujuan, LI Ping

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  105-109.  doi:10.6040/j.issn.1671-7554.0.2017.228

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Objective To explore the mediating effect of perceived stress on the relationship between mindfulness level and psychological distress in infertile women. Methods The 10-item Kessler Psychological Distress Scale(K10), Mindful Attention Awareness Scale(MAAS), and 10-item Perceived Stress Scale(PSS-10)were adopted to survey infertile women. Structure Equation Modeling(SEM)and bootstrapping procedure were used to verify the mediating effect. Results The prevalence of psychological distress among infertile women was 79.6%. Spearman correlation analysis showed that there existed a moderate negative correlation between mindfulness level and perceived stress(r_s=-0.529, P<0.001), and psychological distress(r_s=-0.600, P<0.001); there was a moderate positive correlation between perceived stress and psychological distress(r_s=0.691, P<0.001). SEM indicated that mindfulness level had significant direct effects on perceived stress(β=-0.67, P<0.001)and psychological distress(β=-0.31, P=0.007); perceived stress had a significant direct effect on psychological distress (β=0.64, P<0.001). Furthermore, perceived stress mediated the relationship between mindfulness level and psychological distress. The 95% confidence interval(95%CI)from Bootstrap output was(-0.628, -0.299, P<0.001)and the mediating effect accounted for 58.1% of the total effect. Conclusion Psychological distress was common among infertile women. The mediating role of perceived stress may provide potential mechanism for exploring the relationship between mindfulness level and psychological distress.

Correlation between posttraumatic growth and psychological adjustment of cancer survivors based on Pearson correlation coefficient: a Meta-analysis

LIN Pingzhen, XUE Jiaomei, YANG Bei, LI Meng, ZHOU Mailin, CAO Fenglin

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  110-121.  doi:10.6040/j.issn.1671-7554.0.2016.1413

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Objective To explore the relationship between posttraumatic growth(PTG)and psychological adjustment in cancer population. Methods Databases including PubMed, Elsevier ScienceDirect, Web of Science, Cochrane library, CNKI, CBM, VIP and WanFang were searched from inception to Oct. 2016 for literatures on the correlation between PTG and psychological adjustment in cancer survivors. And then studies retrieved were screened according to the inclusion and exclusion criteria. After data were extracted, and the quality of studies included was assessed, a Meta-analysis was conducted using Stata12.0 software. Results A total of 43 studies with 7,589 patients were included. The results of Meta-analyses showed that PTG was associated with depression(r=-0.18), total quality of life(Qol, r=0.22), and positive affect(r=0.36). Conclusion High PTG is related to reduced depression, increased total QoL, and better positive affect.

Reliability and validity of Chinese Version of the Cultural Value Orientation Scale and correlation between cultural value orientation and psychological health

LI Huafang, ZHANG Hongjing

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  122-127.  doi:10.6040/j.issn.1671-7554.0.2016.1292

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Objective To validate the reliability and validity of the Chinese Version of Cultural Value Orientation(CVO)among Chinese youth and to explore the correlation between cultural value orientation and psychological health of the youth. Methods A total of 938 Chinese youth were surveyed with CVO. The scales reliability and validity were analyzed with Cronbach α, exploratory factor analysis(EFA), and confirmatory factor analysis(CFA).The correlation between cultural value orientation and psychological health was analyzed with the general health questionnaire(GHQ-28). Results The Cranach α of familism, individualism and collectivism was 0.88, 0.73 and 0.84, respectively. The CFA models RMSEA indices were 0.04, 0.03 and 0.05(RMSEA≤0.05). Psychological health(GHQ)was significantly correlated with familism and collectivism(r=-0.24, r=-0.14, P<0.01), but not with individualism(r=-0.06, P>0.05). Conclusion The Chinese Version of CVO has good reliability and validity. Familism and collectivism have significant effects on psychological health.

State of subjective life quality and self-consciousness of left-behind children in rural area of Zaozhuang

ZHU Jianlei, LIU Jintong, WANG Yang, WANG Duanwei, ZHU Xiaomeng, ZHANG Shanjing, ZHU Jianwei

JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES). 2017, 55(9):  128-132.  doi:10.6040/j.issn.1671-7554.0.2016.1567

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Objective To investigate the state of subjective life quality and self-consciousness of left-behind children in the rural area of Zaozhuang City, in order to provide theoretical foundation for the improvement of left-behind childrens life quality and mental health. Methods Inventory of Subjective Life Quality(ISLQ)and Piers-Harris Childrens Self-consciousness Scale(PHCSS)were adopted to investigate left-behind children(n=429, the left-behind group)and non-left-behind children(n=510, non-left-behind group)from three rural primary schools in Zaozhuang. Results The total score and scores of some factors of ISLQ, and the total score of PHCSS of the left-behind group were significantly lower than those of the non-left-behind group(P<0.05). The total score of ISLQ and its factors were positively correlated with the total score of PHCSS and its factors(P<0.01). Conclusion Compared with non-left-behind children, the left-behind children have poorer subjective life quality and lower level of self-consciousness, and the subjective life quality is closely correlated with self-consciousness.