JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (2): 50-54.doi: 10.6040/j.issn.1671-7554.0.2016.1239

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CT-guided interstitia 125I seed implantation in the treatment of long bone metastasis: a primary clinic study

LI Yang, HE Chuang, CHEN Yuxiao, YANG Li, LI Liangshan, LI Tingyuan, HUANG Xuequan   

  1. Department of Intervention, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
  • Received:2016-09-30 Online:2017-02-10 Published:2017-02-10

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Abstract: Objective To evaluate the clinical efficacy of the implantation of 125I radioactive seeds in the treatment of long bone metastasis. Methods The clinical data of 18 cases were collected along with their imaging data. The lesions located in the humerus(n=8), thighbone(n=14), and fibula(n=1). The patients pain was observed by using the numerical rating scale(NRS), and the functions of patients were investigated with the Musculoskeletal Tumor Society(MSTS)scoring system before and after surgery. The survival rate was described with Kaplan-Meier survival curve. Results All of the 23 radiotherapy targets were implanted with 125I seeds. The gross tumor volume(GTV)was(29.25±22.06)cc, and the radioactive activity of seed was 0.80 mCi. Median number of seeds implanted in lesions was 27(15, 36). The postoperative target verified dose D90 was(11 538.1±1 888.6)cGy. The mean follow-up was 9 months(ranging from 3 to 48 months).The NRS and MSTS scores were both improved significantly during the follow-up(P<0.001, P<0.05). Medium survival time was 10 months, while the survival rate for 6, 12 and 24 months was 70.8%, 41.3% and 23.6%, respectively. Conclusion CT-guided 125I seed implantation is an effective and safe palliative care for long bone metastasis, which can effectively relieve the pain and improve the functions of patients.

Key words: 125I radioactive seeds, Brachytherapy, Long bone metastasis, X-ray computed, Tomography

CLC Number: 

  • R739.93
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