JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (2): 38-44.doi: 10.6040/j.issn.1671-7554.0.2016.1350

Previous Articles     Next Articles

CT-guided 125I seed brachytherapy for superficial lymph node metastases: a report of 23 cases

LIN Qi, ZHANG Ying, DAI Jianjian, XU Ruicai, YANG Qi, GENG Baocheng, HAN Mingyong   

  1. Department of Health Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2016-10-20 Online:2017-02-10 Published:2017-02-10

Abstract: Objective To evaluate the efficacy and complications of CT-guided permanent 125I seed brachytherapy in patients with the superficial lymph node metastases. Methods Clinical data of 23 patients with 28 superficial lymph node metastases who underwent CT-guided 125I seed brachytherapy during Dec. 2014 and Jun. 2016 were retrospectively reviewed. Brachytherapy was preplanned for all patients using a 3-dimensional radiation therapy planning system. With CT guidance, 125I seed was placed into the metastases. Dosimetry verification was performed immediately after operation. Efficacy and complications were evaluated 1, 3, 6, 9 and 12 months postoperatively. Results The median local control rate of 1, 3, 6, 9 and 12 months was 84.6%, 82.4%, 81.2%, 83.3% and 85.7%, respectively. The median follow-up was 9 months(1-16 months), during which 8 patients died and 15 survived. The local control time was 12 months(95% CI: 7.4, 16.5), the median progression-free-survival(PFS)was 3 months(95% CI: 0.3, 5.7), P=0.194. No major complications occurred during or after brachytherapy except for Ⅰ/Ⅱ acute skin radioreaction in 6 cases. Conclusion CT-guided 125I seed brachytherapy is a safe and effective treatment for superficial lymph node metastases with few complications.

Key words: Complications, Local control rate, Superficial lymph node metastases, 125I seed

CLC Number: 

  • R730.5
[1] 汤钊猷. 现代肿瘤学[M]. 上海: 上海医科大学出版社, 1993: 102.
[2] 谷铣之, 殷蔚伯, 刘泰福, 等. 肿瘤放射治疗学[M]. 北京: 北京医科大学、中国协和医科大学联合出版社, 1991: 143.
[3] 王俊杰, 修典荣, 冉维强. 放射性粒子组织间近距离治疗肿瘤[M]. 北京: 北京大学医学出版社, 2014: 162-174.
[4] Huo X, Wang H, Yang J, et al. Effectiveness and safety of CT-guided 125I seed brachytherapy for postoperative locoregional recurrence in patients with none-small cell lung cancer[J]. Brachytherapy, 2016, 15(3): 370-380.
[5] 房菲菲, 张颖, 林琦, 等. CT引导放射性125I粒子植入治疗转移性肝癌的临床疗效[J]. 山东大学学报(医学版), 2016, 54. doi:10.6040/j.issn.16717554.0.2016.1106. FANG Feifei, ZHANG Ying, LIN Qi, et al. Clinical efficacy of CT guided 125I seed brachytherapy in the treatment of metastatic hepatic carcinoma[J]. Journal of Shandong University(Health Sciences), 2016, 54. doi:10.6040/j.issn.16717554.0.2016.1106.
[6] Lin L, Wang J, Jiang Y, et al. Interstitial 125I seed implantation for cervical lymph node recurrence after multimodal treatment of thoracic esophageal squamous cell carcinoma[J]. Technol Cancer Res Treat, 2015, 14(2): 201-207.
[7] Gao F, Li C, Gu Y, et al. CT-guided 125I brachytherapy for mediastinal metastatic lymph nodes recurrence from esophageal carcinoma: effectiveness and safety in 16 patients[J]. Eur J Radiol, 2013, 82(2): 70-75.
[8] 高飞, 顾仰葵, 黄金华, 等. CT引导下125Ⅰ近距离治疗肝癌腹膜后转移性淋巴结的临床价值[J]. 中华医学杂志, 2013, 93(27): 2155-2157. GAO Fei, GU Yangkui, HUANG Jinhua, et al. Clinical value of CT-guided 125I brachytherapy for retroperitoneal metastatic lymph node from PHC[J]. National Medical Journal of China, 2013, 93(27): 2155-2157.
[9] 蒲德利, 廖江荣, 彭刚. 放射性125I粒子植入近距离放射治疗18例口腔癌的疗效观察[J]. 介入放射学杂志, 2013, 22: 851-853. PU Deli, LIAO Jiangrong, PENG Gang. The therapeutic effect of brachytherapy with125I seed implantation for oral cancer: observation of 18 cases[J]. J Intervent Radiol, 2013, 22: 851-853.
[10] Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumors: revised RECIST guideline(version1.1)[J]. Eur J Cancer, 2009, 45(2):228-247.
[11] Cox JD, Stetz J, Pajak TF. Toxicity criteria of the radiation therapy oncology group(RTOG)and the european organization for research and treatment of cancer(EORTC)[J]. Int J Radiat Oncol Biol Phys, 1995, 31(5): 1341-1346.
[12] Yao L, Jiang Y, Jiang P, et al. CT-guided permanent 125I seed interstitial brachytherapy for recurrent retroperitoneal lymph node metastases after external beam radiotherapy[J]. Brachytherapy, 2015, 14(5): 662-669.
[13] 柴树德, 郑广钧. 胸部肿瘤放射性粒子治疗学[M]. 北京: 人民卫生出版社, 2012: 17-29.
[14] Zhang T, Lu M, Peng S, et al. CT-guided implantation of radioactive 125I seed in advanced non-small-cell lung cancer after failure of first-line chemotherapy[J]. J Cancer Res Clin Oncol, 2014, 140(8): 1383-1390.
[15] Li J, Xie Q, Wang W, et al. CT-guided implantation of 125I seeds(permanent brachytherapy)for metastatic tumors of the hepatic portal system: effectiveness and safety in 13 patients[J]. Brachytherapy, 2016, 15(2): 224-230.
[16] Li W, Guan J, Yang L, et al. Iodine-125 brachytherapy improved overall survival of patients with inoperable stage Ⅲ/Ⅳ non-small cell lung cancer versus the conventional radiotherapy[J]. Med Oncol, 2015, 32(1): 395. doi: 10.1007/s12032-014-0395-8.
[17] Aronowitz JN.Introduction of transperineal image-guided prostate brachytherapy[J]. Int J Radiat Oncol Biol Phys, 2014, 89(4): 907-915.
[18] Zuber S, Wei S, Baaske D, et al. Iodine-125 seed brachytherapy for early stage prostate cancer: a single-institution review[J]. Radiat Oncol, 2015, 10: 49. doi: 10.1186/s13014-015-0349-0.
[19] Zhang L, Lu J, Wang Z, et al. Clinical efficacy of computed tomography-guided iodine-125 seed implantation therapy in patients with advanced spinal metastatic tumors[J]. Onco Targets Ther, 2015, 9: 7-12. doi: 10.2147/OTT.S95410.
[20] Zhang L, Chen LH, Wang J, et al. CT-guided radioactive 125I seed implantation treatment of multiple pulmonary metastases of hepatocellular carcinoma[J]. Clin Radiol, 2014, 69(6): 624-629.
[21] Xiang Z, Mo Z, Li G, et al. 125I brachytherapy in the palliation of painful bone metastases from lung cancer after failure or rejection of conventional treatments[J]. Oncotarget, 2016, 7(14): 18384-18393.
[22] Gobardhan PD, de Wall LL, van der Laan L, et al. The role of radioactive iodine-125 seed localization in breast-conserving therapy following neoadjuvant chemotherapy[J]. Ann Oncol, 2013, 24(3): 668-673.
[23] 张忠涛, 隋庆兰. 吴善良, 等. CT导引植入125I放射性粒子治疗颈部淋巴结转移癌的临床应用[J]. 介入放射学杂志, 2015, 24(10): 881-884. ZHANG Zhongtao, SUI Qinglan, WU Shanliang, et al. Clinical application of CT-guided 125I radioactive seed implantation in treating cervical lymph node metastasis[J]. J Intervent Radiol, 2015, 24(10): 881-884.
[24] 王娟, 孙美玲, 张宏涛, 等. 外放疗后复发颈部淋巴结转移癌17例125I粒子植入治疗的初步疗效[J]. 介入放射学杂志, 2014, 23(9): 784-787. WANG Juan, SUN Meiling, ZHANG Hongtao, et al. Radioactive 125I seed implantation for the treatment of recurrent cervical lymphatic metastases after radiotherapy: preliminary results in 17 cases[J]. J Intervent Radiol, 2014, 23(9): 784-787.
[25] 张颖, 林琦, 袁苑, 等. 3D打印个体化模板联合CT引导125I粒子植入治疗恶性肿瘤质量评价[J]. 山东大学学报(医学版), 2016, 54(11): 44-50. ZHANG Ying, LIN Qi, YUAN Yuan, et al. The feasibility of 3D print individual template combined with CT guided 125I seed implantation for malignant tumor[J]. Journal of Shandong University(Health Sciences), 2016, 54(11): 44-50.
[26] 张颖, 林琦, 韩明勇, 等. 3D打印个体化模板联合CT引导治疗胸壁肿瘤1例[J]. 山东大学学报(医学版), 2016, 54(4): 94-96.
[27] 王俊杰. 3D打印技术与精准粒子植入治疗学[M]. 北京: 北京大学医学出版社, 2016: 54-63.
[28] 江萍, 马月, 王俊杰, 等. 超声引导放射性125I粒子植入治疗头颈部复发肿瘤[J]. 北京大学学报(医学版), 2012, 44(2): 291-294. JIANG Ping, MA Yue, WANG Junjie, et al. Ultrasound guided implantation of radioactive 125I seeds for treatment of recurrent head and neck carcinomas[J]. Journal of Peking University(Health Sciences), 2012, 44(2): 291-294.
[1] GUO Zhihua, ZHAO Daqing, XING Yuan, WANG Wei, LIANG Leping, YANG Jing, ZHAO Qianqian. Single-stage end-to-end anastomosis in the management of severe cervical tracheal stenosis [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 72-76.
[2] CAO Qianqian, JIANG Yuhua, LI Yuliang, YANG Ruijie, LIU Lu, ZHANG Xile, WANG Junjie. A dosimetric analysis of cervical metastases between radioactive 125I seeds implantation and external beam radiation therapy [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(7): 55-60.
[3] LU Ye, CUI Huifang, CHEN Xujun, HUANG Yihua, WU Yiqun, HUANG Jianlong, CHEN Huimin, XIONG Xianjun, CHEN Minghong. Application progress of freezing technology in intervention treatment of respiratory disease and preventive treatment for the correlated complications [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(4): 19-22.
[4] WANG Juan, ZHANG Hongtao, GAO Zhen, DI Xuemin, WANG Zeyang. Prevention and treatment of complications of abdominal tumor by radioactive seeds implantation [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 8-13.
[5] DAI Jianjian, YUAN Bing, ZHANG Ying, LIN Qi, YUAN Yuan, HAN Mingyong. CT-guided percutaneous 125I seed implantation brachytherapy in patients with stage Ⅲ non-small-cell lung cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 32-37.
[6] XU Yujun, LIU Ming, HE Xiangmeng, LI Chengli. 1.0T open MRI-guided 125I seeds percutaneous implantation for advanced pancreatic cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 21-25.
[7] LIANG Fei, ZHANG Wenlong, ZHANG Jun, XU Chongen, ZOU Chengwei. Relevant factors and early complications of significantly elevated enzymes after off-pump coronary artery bypass grafting [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 71-75.
[8] FANG Feifei, ZHANG Ying, LIN Qi, YUAN Yuan, DAI Jianjian, XU Ruicai, GENG Baocheng, HAN Mingyong. Clinical efficacy of CT-guided 125I seed brachytherapy in the treatment of metastatic hepatic carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(12): 53-57.
[9] ZHANG Ying, LIN Qi, YUAN Yuan, DAI Jianjian, GENG Baocheng, XU Ruicai, LIU Yakun, HAN Mingyong. Feasibility of 3D print individual template combined with CT-guided 125I seed implantation for malignant tumors [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(11): 44-50.
[10] ZHAO Heng, YIN Qingfeng, LIU Wenguang, LIU Shenghou, XIAO Shipeng, WANG Shaojin. Application of a novel barbed suture in wound closure of hip and knee replacement [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(8): 53-56.
[11] HU Liang, YI Yong-xiang, DING Hai, HAN Jian-bo, LIU Tao, ZHAO Liang. Relevant factors of postoperative complications for hepatectomy combined with splenectomy [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(1): 64-66.
[12] LI Zhen-zuo1,2, ZHANG Yan3, MA Chi-cheng4, LIU Jin-bo1, SUN Yu1, HOU Xin-guo1, CHEN Li1. Association of serum vaspin with carotid plaque in new type 2 diabetic patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(10): 79-.
[13] ZHAO Lijian, HAN Bo, ZHANG Jianjun, ZHUANG Jianxin, JIN Youpeng, WANG Yulin. Evaluation of transcatheter closure in 90 cases ofcongenital ventricular septal defect [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(5): 89-92.
[14] . Posterior chamber implantable contact lens for 18 cases of high myopia [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(10): 134-138.
[15] XI Jie, WU Shuming, PANG Xinyan, et al. Perioperative application of intraaortic balloon pump in critical patients with coronary disease [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(01): 82-84.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!