JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (12): 53-57.doi: 10.6040/j.issn.1671-7554.0.2016.1106

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Clinical efficacy of CT-guided 125I seed brachytherapy in the treatment of metastatic hepatic carcinoma

FANG Feifei, ZHANG Ying, LIN Qi, YUAN Yuan, DAI Jianjian, XU Ruicai, GENG Baocheng, HAN Mingyong   

  1. Department of Health Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2016-09-03 Online:2016-12-10 Published:2016-12-10

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Abstract: Objective To evaluate the efficacy and complications of CT-guided permanent 125I seed interstitial brachytherapy in the treatment of metastatic hepatic carcinoma. Methods A total of 22 patients with metastatic hepatic carcinoma were enrolled. A treatment plan was made for each patient using a computerized treatment planning system(TPS)to determine the dose of radioactive seeds implanted and the site. With CT guidance, 125I seeds were placed into the metastatic sites in the liver. After operation, CT scan was performed to verify the position and intensity of 125I seeds. CT scan was performed 1 month, 3, 6, 9 and 12 months after operation to evaluate the local control rate of tumor and complications. Results Altogether 27 liver lesions were included in this study. The median longest diameter was 3.4 cm(1.0-7.4 cm). The number of 125I seeds was 4-87. The activity was 1.85×107-2.96×107 Bq(0.5-0.8 mCi). One month after operation, 11 patients gained complete remission(CR), 6 partial remission(PR), 5 stable disease(SD)and 5 progression of disease(PD). The local tumor control rate 1 month, 3, 6, 9 and 12 months after operation was 81.5%, 78.9%, 76.9%, 77.8% and 66.7%, respectively. During the follow-up of 1-14 months(median 6 months), 13 patients survived and 9 died. The median survival time for all patients was 12 months. The rate of pain relief was 91.7%. Minor complications were bleeding ［31.8%(7/22)］, nsusea/vomiting ［13.6%(3/22)］, 山 东 大 学 学 报 (医 学 版)54卷12期 -房菲菲,等.CT引导放射性125I粒子植入治疗转移性肝癌的临床疗效 \=- fever［4.5%(1/22)］ and seed displacement ［9.1%(2/22)］. Conclusion CT-guided 125I seed brachytherapy is a safe and effective treatment for metastatic hepatic carcinoma with few complications.

Key words: 125I seed, Complications, Local control rate, Liver malignancies

CLC Number: 

  • R735.7
[1] 傅志强, 周琪, 侯克柱, 等. 经皮肝穿刺微波热凝治疗转移性肝癌的疗效评价[J]. 中华临床医师杂志, 2016, 10(8): 1071-1073. FU Zhiqiang, ZHOU Qi, HOU Kezhu, et al. Therapeutic evaluation of percutaneous microwave coagulation therapy for metastatic hepatic carcinoma[J]. Chinese Journal of Clinicians, 2016, 10(8): 1071-1073.
[2] Yao L, Jiang Y, Jiang P, et al. CT-guided permanent 125I seed interstitial brachytherapy for recurrent retroperitoneal lymph node metastases after external beam radiotherapy[J]. Brachytherapy, 2015, 14(5): 662-669.
[3] Li C, Zhang F, Zhang W, et al. Feasibility of 125I brachytherapy combined with sorafenib treatment in patients with multiple lung metastases after liver transplantation for hepatocellular carcinoma[J]. J Cancer Res Clin Oncol, 2010, 136(11):1633-1640.
[4] Gao F, Li C, Gu Y, et al. CT-guided 125I brachytherapy for mediastinal metastatic lymph nodes recurrence from esophageal carcinoma: effectiveness and safety in 16 patients[J]. Eur J Radiol, 2013, 82(2):70-75.
[5] Keyes M, Morris WJ, Spadinger I, et al. Radiation oncology and medical physicists quality assurance in British Columbia Cancer Agency Provincial Prostate Brachytherapy Program[J]. Brachytherapy, 2013, 12(4): 343-355.
[6] Zhang L, Lu J, Wang Z, et al. Clinical efficacy of computed tomography-guided iodine-125 seed implantation therapy in patients with advanced spinal metastatic tumors[J]. Onco Targets Ther, 2015, 9: 7-12. doi: 10.2147/OTT.S95410.
[7] Xiang Z, Mo Z, Li G, et al. 125I brachytherapy in the palliation of painful bone metastases from lung cancer after failure or rejection of conventional treatments[J]. Oncotarget, 2016, 7(14): 18384-18393.
[8] Huo X, Wang H, Yang J, et al. Effectiveness and safety of CT-guided 125I seed brachytherapy for postoperative locoregional recurrence in patients with none-small cell lung cancer[J]. Brachytherapy, 2016, 15(3): 370-380.
[9] Gobardhan PD, de Wall LL, van der Laan L, et al. The role of radioactive iodine-125 seed localization in breast-conserving therapy following neoadjuvant chemotherapy[J]. Ann Oncol, 2013, 24(3): 668-673.
[10] Wang Z, Lu J, Liu L, et al.Clinical application of CT-guided 125I seed interstitial implantation for local recurrent rectal carcinoma[J]. Radiat Oncol, 2011, 6: 138. doi: 10.1186/1748-717X-6-138.
[11] Zuber S, Weiß S, Baaske D, et al. Iodine-125 seed brachytherapy for early stage prostate cancer: a single-institution review[J]. Radiat Oncol, 2015, 10: 49. doi: 10.1186/s13014-015-0349-0.
[12] Wang J, Yuan H, Ma Q, et al. Interstitial 125I seeds implantation to treat spinal metastatic and primary paraspinal malignancies[J]. Med Oncol, 2010, 27(2): 319-326.
[13] 曲昂, 王俊杰. 125I粒子置入治疗非小细胞肺癌癌症进展现状[J]. 癌症进展, 2013, 11(1): 53-55.
[14] 柳晨, 王俊杰, 孟娜, 等. CT引导下放射性125I粒子置入治疗脊柱转移性肿瘤的价值[J]. 中国脊柱脊髓杂志, 2011, 21(3): 226-229. LIU Chen, WANG Junjie, MENG Na, et al. CT-guide interstitial iodine-125 seed implantation for metastatic spine tumor[J]. Chinese Journal of Spine and Spinal Cord, 2011, 21(3): 226-229.
[15] Li J, Xie Q, Wang W, et al. CT-guided implantation of 125I seeds(permanent brachytherapy)for metastatic tumors of the hepatic portal system: Effectiveness and safety in 13 patients[J]. Brachytherapy, 2016, 15(2): 224-230.
[16] 冉琳, 陈鹏, 彭勤中. 经皮超声引导下125I粒子植入治疗肝脏肿瘤[J]. 中国超声医学杂志, 2010, 26(6): 520-523. RAN Lin, CHEN Peng, PENG Qinzhong, et al. Radioactive seed 125I Implantion in Treatment of Liver tumor with Ultrasonographic Guidance[J]. Chinese Journal of Ultrasound in Medicine, 2010, 26(6): 520-523.
[17] Sharma DN, Thulkar S, Sharma S, et al. High-dose-rate interstitial brachytherapy for liver metastases: first study from India[J]. J Contemp Brachytherapy, 2013, 5(2): 70-75.
[18] 张福君, 吴沛宏, 焦德超, 等. CT导向125I粒子植入治疗肝癌肝转移术后复发/转移瘤的近中期疗效[C]. 中国(第七届)肿瘤微创治疗学术大会暨世界影响导引下肿瘤微创治疗学会成立筹备大会论文汇编. 2011.
[19] Zhongmin W, Yu L, Fenju L, et al. Clinical efficacy of CT-guided iodine-125 seed implantation therapy in patients with advanced pancreatic cancer[J]. Eur Radiol, 2010, 20(7): 1786-1791.
[20] Zhang L, Chen LH, Wang J, et al. CT-guided radioactive 125I seed implantation treatment of multiple pulmonary metastases of hepatocellular carcinoma[J]. Clin Radiol, 2014, 69(6): 624-629.
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