JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (12): 53-57.doi: 10.6040/j.issn.1671-7554.0.2016.1106

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Clinical efficacy of CT-guided 125I seed brachytherapy in the treatment of metastatic hepatic carcinoma

FANG Feifei, ZHANG Ying, LIN Qi, YUAN Yuan, DAI Jianjian, XU Ruicai, GENG Baocheng, HAN Mingyong   

  1. Department of Health Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China
  • Received:2016-09-03 Online:2016-12-10 Published:2016-12-10

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Abstract: Objective To evaluate the efficacy and complications of CT-guided permanent 125I seed interstitial brachytherapy in the treatment of metastatic hepatic carcinoma. Methods A total of 22 patients with metastatic hepatic carcinoma were enrolled. A treatment plan was made for each patient using a computerized treatment planning system(TPS)to determine the dose of radioactive seeds implanted and the site. With CT guidance, 125I seeds were placed into the metastatic sites in the liver. After operation, CT scan was performed to verify the position and intensity of 125I seeds. CT scan was performed 1 month, 3, 6, 9 and 12 months after operation to evaluate the local control rate of tumor and complications. Results Altogether 27 liver lesions were included in this study. The median longest diameter was 3.4 cm(1.0-7.4 cm). The number of 125I seeds was 4-87. The activity was 1.85×107-2.96×107 Bq(0.5-0.8 mCi). One month after operation, 11 patients gained complete remission(CR), 6 partial remission(PR), 5 stable disease(SD)and 5 progression of disease(PD). The local tumor control rate 1 month, 3, 6, 9 and 12 months after operation was 81.5%, 78.9%, 76.9%, 77.8% and 66.7%, respectively. During the follow-up of 1-14 months(median 6 months), 13 patients survived and 9 died. The median survival time for all patients was 12 months. The rate of pain relief was 91.7%. Minor complications were bleeding ［31.8%(7/22)］, nsusea/vomiting ［13.6%(3/22)］, 山 东 大 学 学 报 (医 学 版)54卷12期 -房菲菲,等.CT引导放射性125I粒子植入治疗转移性肝癌的临床疗效 \=- fever［4.5%(1/22)］ and seed displacement ［9.1%(2/22)］. Conclusion CT-guided 125I seed brachytherapy is a safe and effective treatment for metastatic hepatic carcinoma with few complications.

Key words: 125I seed, Complications, Local control rate, Liver malignancies

CLC Number: 

  • R735.7
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