JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (2): 21-25.doi: 10.6040/j.issn.1671-7554.0.2016.1476

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1.0T open MRI-guided 125I seeds percutaneous implantation for advanced pancreatic cancer

XU Yujun, LIU Ming, HE Xiangmeng, LI Chengli   

  1. Department of Interventional MRI, Shandong Medical Imaging Research Institute of Shandong University, Jinan 250021, Shandong, China
  • Received:2016-11-09 Online:2017-02-10 Published:2017-02-10

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Abstract: Objective To evaluate the feasibility, safety and efficacy of 1.0T open MRI-guided 125I seeds percutaneous implantation in the treatment of unresectable advanced pancreatic cancer. Methods A group of 31 patients with confirmed unresectable advanced pancreatic cancer were enrolled. The treatment plan was designed with treatment plan system(TPS)before implantation. With prescription dose(PD)being 120~160 Gy, D90>90%PD, V100>90%, V200<50%, under the 1.0T open MRI guidance, 125I seeds were implanted. Dosimetric verification was conducted within 24 h after surgery. Results All 31 procedures were successful. After implantation, TPS showed D90, V100 and V200 ranged 91%-112%PD, 92%-106%, and 21%-49%, respectively. The patients were rechecked 1, 3, 6 and 12 months after operation, and after that once a year. The median survival was 14.7, 16.3 and 5.9 months for the whole group, for patients with stage Ⅲ cancer and stage Ⅳ cancer. The effective rate was 83.8%, local control rate was 93.5%, and pain relief rate was 91.6%. No serious complications such as pancreatitis, pancreatic fistula, intestinal fistula and hemorrhage were observed. Conclusion 1.0T open MRI-guided 125I seeds percutaneous implantation is safe, feasible and effective for unresectable advanced pancreatic cancer.

Key words: 125I seeds, Unresectable, Pancreatic cancer, Magnetic resonance imaging

CLC Number: 

  • R735.9
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