JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (2): 21-25.doi: 10.6040/j.issn.1671-7554.0.2016.1476

Previous Articles     Next Articles

1.0T open MRI-guided 125I seeds percutaneous implantation for advanced pancreatic cancer

XU Yujun, LIU Ming, HE Xiangmeng, LI Chengli   

  1. Department of Interventional MRI, Shandong Medical Imaging Research Institute of Shandong University, Jinan 250021, Shandong, China
  • Received:2016-11-09 Online:2017-02-10 Published:2017-02-10

PDF (PC)

213

Abstract: Objective To evaluate the feasibility, safety and efficacy of 1.0T open MRI-guided 125I seeds percutaneous implantation in the treatment of unresectable advanced pancreatic cancer. Methods A group of 31 patients with confirmed unresectable advanced pancreatic cancer were enrolled. The treatment plan was designed with treatment plan system(TPS)before implantation. With prescription dose(PD)being 120~160 Gy, D90>90%PD, V100>90%, V200<50%, under the 1.0T open MRI guidance, 125I seeds were implanted. Dosimetric verification was conducted within 24 h after surgery. Results All 31 procedures were successful. After implantation, TPS showed D90, V100 and V200 ranged 91%-112%PD, 92%-106%, and 21%-49%, respectively. The patients were rechecked 1, 3, 6 and 12 months after operation, and after that once a year. The median survival was 14.7, 16.3 and 5.9 months for the whole group, for patients with stage Ⅲ cancer and stage Ⅳ cancer. The effective rate was 83.8%, local control rate was 93.5%, and pain relief rate was 91.6%. No serious complications such as pancreatitis, pancreatic fistula, intestinal fistula and hemorrhage were observed. Conclusion 1.0T open MRI-guided 125I seeds percutaneous implantation is safe, feasible and effective for unresectable advanced pancreatic cancer.

Key words: 125I seeds, Unresectable, Pancreatic cancer, Magnetic resonance imaging

CLC Number: 

  • R735.9
[1] Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010[J]. CA Cancer J Clin, 2010, 60(5): 277-300.
[2] Zhang B, Dong Y, Liu J, et al. Immunotherapy for patients with advanced pancreatic carcinoma: a promising treatment[J]. Oncotarget, 2016, 15. doi:18632/oncotarget.13968.[Epub ahead of print].
[3] Ceha HM, van Tienhoven G, Gouma DJ, et al. Feasibility and efficacy of high dose conformal radiotherapy for patients with locally advanced pancreatic carcinoma[J]. Cancer, 2000, 89(11): 2222-2229.
[4] Sultana A, Tudur Smith C, Cunningham D, et al. Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy[J]. Br J Cancer, 2007, 96(8): 1183-1190.
[5] Niu H, Zhang X, Wang B, et al, The clinical utility of image-guided iodine-125 seed in patients with unresectable pancreatic cancer[J]. Tumour Biol, 2016, 37(2): 2219-2223.
[6] Wang CF, Zhao P, Li YX, et al, Role of 125I seed implantation in treatment of unresectable pancreatic cancer[J]. Zhonghua Yi Xue Za Zhi, 2010, 90(2): 92-95.
[7] Abrams RA, Lowy AM, OReilly EM, et al. Combined modality treatment of resectable and borderline resectable pancreas cancer: expert consensus statement[J]. Ann Surg Oncol, 2009, 16(7): 1751-1756.
[8] Wang Z, Lu J, Liu L,et al. Clinical application of CT-guided(125)I seed interstitial implantation for local recurrent rectal carcinoma[J]. Radiat Oncol, 2011, 6: 138. doi: 10.1186/1748-717X-6-138.
[9] Gutt R, Liauw SL, Weichselbaum RR. The role of radiotherapy in locally advanced pancreatic carcinoma[J]. Nat Rev Gastroenterol Hepatol, 2010, 7(8): 437-447.
[10] Gillen S, Schuster T, Friess H, et al. Palliative resections versus palliative bypass procedures in pancreatic cancer-a systematic review[J]. Am J Surg, 2012, 203(4): 496-502.
[11] Sugyo A, Tsuji AB, Sudo H, et al. Preclinical evaluation of 89Zr-labeled human antitransferrin receptor monoclonal antibody as a PET probe using a pancreatic cancer mouse model[J]. Nucl Med Commun, 2015, 36(3): 286-294.
[12] Xu JB, Yang XC, Guo JH, et al. Serum nerve growth factor level indicates therapeutic efficacy of 125I seed implantation in advanced pancreatic adenocarcinoma[J]. Eur Rev Med Pharmacol Sci, 2015, 19(18): 3385-3390.
[13] Bodner WR, Hilaris BS, Mastoras DA. Radimion therapy in pancreatic cancer: current practice and future trends[J]. J Clin Gastroenterol, 2000, 30(3): 230-233.
[14] Liu K, Ji B, Zhang W, et al. Comparison of iodine-125 seed implantation and pancreaticoduodenectomy in the treatment of pancreatic cancer[J]. Int J Med Sci, 2014, 11(9):893-896.
[15] Tanimoto R, Bekku K, Ebara S, et al. The impact of neoadjuvant hormone therapy on the permanent 125I-seed brachytherapy for low-or intermediate-risk prostate cancer[J]. J Clin Oncol, 2012, 30(5_suppl):201.
[16] Huang ZM, Pan CC, Wu PH, et al. Efficacy of minimally invasive therapies on unresectable pancreatic cancer[J]. Chin J Cancer, 2013, 32(6): 334-341.
[17] Liu B, Zhou T, Geng J, et al. Percutaneous computed tomography guided iodine 125 seeds implantation for unresectable pancreatic cancer[J]. Indian J Cancer, 2015, 52(2): 69-74.
[18] Li YF, Liu ZQ, Zhang YS, et al. Implantation of radioactive(125)I seeds improves the prognosis of locally advanced pancreatic cancer patients: a retrospective study[J]. J Huazhong Univ Technolog Med Sci, 2016, 36(2): 205-210.
[19] Wang H, Wang J, Jiang Y, et al. The investigation of 125I seed implantation as a salvage modality for unresectable pancreatic carcinoma[J]. J Exp Clin Cancer Res, 2013, 32: 10. doi: 10.1186/1756-9966-32-106.
[20] Wang J, Jiang Y, Li J, et al. Intraoperative ultrasound-guided iodine-125 seed implantation for unresectable pancreatic carcinoma[J]. J Exp Clin Cancer Res, 2009, 28: 88. doi: 10.1186/1756-9966-28-88.
[21] Liu M, Huang J, Xu Y, et al. MR-guided percutaneous biopsy of solitary pulmonary lesions using a 1.0-T open high-field MRI scanner with respiratory gating[J]. Eur Radiol, 2016 Aug 11.[Epub ahead of print].
[1] WANG Yuhong, ZHANG Lihong, WANG Linsheng, CHEN Yueqin, WANG Yanhui, WANG Jiehuan, LI Chuanfu. Imaging features of granular cell tumor in the alimentary system [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(8): 66-70.
[2] CAO Qianqian, JIANG Yuhua, LI Yuliang, YANG Ruijie, LIU Lu, ZHANG Xile, WANG Junjie. A dosimetric analysis of cervical metastases between radioactive 125I seeds implantation and external beam radiation therapy [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(7): 55-60.
[3] WANG Guangbin. Magnetic resonance imaging in the evaluation of pernicious placenta previa [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(9): 7-9.
[4] SHA Sha, Chowdhury Sumon Rahman, CHEN Li, HE Qin, ZHANG Jing, FAN Shanshan, SUN Lei. Effect of liraglutide on leptin and fat content in high fat diet induced obese mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 22-27.
[5] GAO Meng, SUN Jianmin, JIANG Zhensong, CUI Xingang. Diagnostic value of MRI for brucellar spondylitis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 27-30.
[6] DONG Jinye, LIN Xiangtao, CAO Jinfeng, WU Yong, ZHAO Hui, XIE Huihui, XIAO Lianxiang. Fetal cervical enlargement development between 16 and 42 weeks of gestational age: a postmortem MRI study [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(5): 74-78.
[7] ZHANG Zhan, XU Xiangfeng, LIU Haidong, WANG Wei. Diagnostic value of MRI in the T-staging of cervical cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(5): 70-73.
[8] DIAO Xiaojun, CHEN Chunfu, LI Congcong, ZHANG Yingbo, LI Yingying. Characteristics and prevalence of primary headaches in patients with multiple sclerosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(4): 42-45.
[9] SUN Xuyi, HAN Jiankui. Dual-Phase 18F-FDG PET/CT in the diagnosis of benign and malignant pancreatic lesions [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(4): 68-73.
[10] BAO Hongjing, WANG Guangbin, WANG Shanshan, WU Chao. Diffusion-weighted MR neurography of the median nerve in carpal tunnel syndrome: a preliminary study [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(11): 72-75.
[11] DONG Fang, DU Yifeng. Correlation among cognitive impairment and high homocysteinemia as well as the number and volume of infarct in patients with lacunar cerebral infarction [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(10): 46-49.
[12] MENG Xiangshui, CHAI Xiangjun, MA Xiangxing, REN Qingguo, YANG Zhicheng. Value of CT and MRI in the treatment options of laryngeal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(10): 76-79.
[13] ZHANG Yang, LI Wanhu, SONG Weiyang, LIU Chunlei, ZHANG Quan. Distribution pattern of cerebrovascular reactivity in healthy middle-aged or elderly people: a breath holding functional magnetic resonance imaging study [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(5): 85-88.
[14] LI Hongxia, DONG Lei, JIANG Jiong, WANG Xinyang. Effects of peptide YY on apoptosis of human pancreatic cancer cell line Miapaca-2 in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(12): 7-11.
[15] WANG Fengxue, WANG Qian, LI Guimei, HU Yanyan, WANG Zengmin. Correlation between pituitary MRI and endocrine functions in patients with pituitary stalk interruption syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(1): 58-62.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd